s240779 said:
ShiroiTora said:
For this reason I highly recommendation you not to take strychnine with harmalas. It's not only a neurotransmitter thing, metabolizing enzymes are also involved, and if one of them happens to be the one that metabolizes strychnine you might very well end up taking a lethal dose, no matter how careful you are.
In vitro Metabolism of Strychnine by Human Cytochrome P450 and Its Interaction with Glycyrrhetic Acid. (2012). Liu, L., Xiao, J., Peng, Z., Wu, W., Du, P., & Chen, Y. Chinese Herbal Medicines, 4(2), 118-125. DOI: j.issn.1674-6384.2012.02.005
Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives. (2011). Zhao, T., He, Y., Wang, J., Ding, K., Wang, C., & Wang, Z. Phytotherapy Research, 25(11), 1671-1677. DOI: 10.1002/ptr.3458
But you're not taking dose into account. As you saw, I said I only like very low doses of harmalas, i.e. to add some spice to an orally active psychedelic. Such doses are not sufficient for oral DMT and probably aren't sufficient for much of anything (except an observable "spicing up" of a psychedelic). People never seem to want to take dose into account when evaluating things like this. The MAOI attribute of harmalas is, of course, notorious, and people are always warning that, e.g. MDMA and SSRIs are likely fatal in combo with harmalas, and yet there are reports of these combinations, one of them from Bardy, who posted in this thread.* People act as though these combos are so bad that almost any dose will put you in the hospital or kill you. I, myself, tried both Zoloft and Lexapro with low doses harmalas. I didn't get a negative effect (the Zoloft gave me a potent stimulant effect). To just insist that any dose is bad is unscientific. A much more reasonable reply would be to say start with only a fraction of the dose(s).
edit Now I see that you did take dose into account, cuz you said, "no matter how careful you are". I don't know why you would assume such a thing. These aren't, like, the most powerful things in the world. Why would you just assume that it's so dangerous?
*See the bottom of this post:
https://www.shroomery.org/forums/showflat.php/Number/28975090#28975090