To comment on the MDMA/MXE safety:
I plugged a mixture of 90mg MDA and 90mg MDMA then I made myself a capsule of 180mg MDMA to redose with.
I came up very quick on the plugged dose, got into the concert and I was rolling face, then I did somewhere around 80mg MXE intranasal and about an hour later the 180mg MDMA capsule.
It may have been the hardest I've ever rolled (but my gf says I say that every time I do it 8)) My entire body felt "juicy" if that makes any sense. I had a hard time speaking and I blacked out for a short period of time because some girl gave me K and I ended up making out with her (I know this because my friend I went with saw me do it not because I remember).
When I was coming down I couldn't see straight while I was riding my bike but I find that's common for high doses of MXE.
I think the biggest risk is increased risk of serotonin syndrome (the blacking out part makes me think this) however, I did black out last time I took that MDA (due to crazy alcohol/xanax/cocaine/ketamine/MDMA binge) so the mxe might have been totally fine.
still haven't tried MDA by itself yet 8)
TBH yohimbine and MXE felt more toxic and when I didn't get good sleep that night I felt very hungover the next day.