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Dissociatives [Methoxetamine Subthread] Combinations - 2nd experiment

I recently had a lovely experience on .750mg 25c NBOMe and repeated MXE (100-150mg over the night), after a two week break from all drugs, and a couple months from MXE. They do indeed potentate each other. While I was quite clear headed and able to talk with my girl and make her a light dinner while I was in several locations at once, including in Troll Hunter which she was watching, and a epic Japanese rock concert I had playing in the other room, and in the kitchen, while existing in 2d in a 3d world, slipping between worlds and swirling into woodgrain and various textures with the others that were there. Yet my knife hand was steady as I chopped up some greens and radishes. Typing got a bit difficult but not impossible, laying down and closing my eyes was impossible, but I was holed the fuck out anyway. Happy and excited all night long.
Massive insomnia after (which I don't tend to get on either alone), and stiff joints that a long hot shower helped. I'll be trying this again if I can keep myself outta my 25c for a while and keep from ordering MXE for another month or two. Good stuff.
 
fishmael said:
is it safe to combine with tramadol? I don't understand why/why not it wouldn't be.
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I really like the combo. I don't go over 200mg of tramadol (as 2 100mg doses taken an hour apart). With the MXE I do several bumps of 30mg. I find the tramadol slightly takes away some of the psychedelic effects but it makes up for it in euphoria. I found it to actually be kind of rushy.

Like I said I really like the combo, my gf is a fan too. And it makes for some awesome marathon sex.
 
How is it with sex? marathon sex, delsyd? i'll see if my domestic partner will be interested in trying either of the drugs.
 
What are you guys thinking about 5-APB and 6-APB?

But first:
- I'm relatively sure that this could be a very dangerous combination
- IF somebody experienced a trip with this combo: Lemme know!

My most important question:
How long should I wait after a 5-/6-APB trip before starting with MXE? Would you say 2 more or less whole days should be enough??
 
The sex is awesome. I've been with the same partner for 5.5 years now and sex on MXE might have been the best that I've experienced and she feels the same way. When on tramadol and MXE the high becomes more euphoric and erotic IMO. I'm also able to hold off having an orgasm untill I choose to. It's really pretty amazing.
Up there with having sex on LSD or getting head after blasting off on DMT (my 2 best sex and drugs experiences before trying MXE)
 
garchi said:
What are you guys thinking about 5-APB and 6-APB?

But first:
- I'm relatively sure that this could be a very dangerous combination
- IF somebody experienced a trip with this combo: Lemme know!

My most important question:
How long should I wait after a 5-/6-APB trip before starting with MXE? Would you say 2 more or less whole days should be enough??
Click to expand...


Combining MXE and serotonergic drugs has led to a lot of negative experiences. I wouldn't do it.
 
I've not yet tried MXE, however three friends took some (a lot, they dosed it as ketamine!) without my knowledge when we returned from a night out drinking and taking in their case a moderate amount of coke. Not surprisingly they were close to holing, unable to move or speak and one of them had blood coming from his nose. I was on aMT at the time and also fairly drunk, when I realised what they done I was fairly terrified. Thankfully a sober chap was around and after some careful consideration he convinced me that an ambulance wasn't required (I actually came on here to check on coke + MXE, as my main fear was 5-HT syndrome once I was convinced they were breathing fine). Bad times.
 
cryptix420 said:
diphenhydramine and phenibut may have dangerous interactions with MXE.
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What do you mean by that? I've taken MXE after phenibut quite a few times and never had any issues (DXM with phenibut is a different story...) Also, I've used diphenhydramine afterwards to help sleep and never had a problem with that either- only 25 or 50mg, not large doses. Did you have a bad experience?
 
I suppose I should elaborate a bit.

It started when I began taking MXE every day for a week, ran out, ordered more, and did it for another few days. I then decided to take my blotters of 25c-NBOMe. I have tried 25i extensively, but never 25c. I (stupidly) took 2.4mg on blotters, and went for a bike ride. I biked about 15 miles until the visuals started to get too heavy to be able to bike. I pulled over onto a sidewalk and horrible evil memories of my stepmom from my childhood began playing like a movie being projected from my mind. I had some water and tried to eat a banana but had to spit it out in disgust.

I realized I needed to get my ass home, because this trip was intense as fuck. I got almost bike to my houes before I started to lose my shit. I abandoned my bike on the sidewalk, along with my phone and backpack, and began sprinting after another biker who had water, screaming for help and asking for water. I then remember laying down on the sidewalk from being tired, and a woman looking at me asking if I needed an ambulance. I said no, and from then on all I really remember is screaming my last words at the people around me as I saw (or thought I saw) myself laying in a pool of my own blood. I remember thinking I was in the midst of battle between heaven and hell, and trying to battle of what I thought were demons, but were actually just paramedics.

I woke up 15 hours later due to the propofol and versed IV's they had given me, and charcoal they had pumped down my stomach. I woke up with a breathing tube in my throat (which still causes me lasting pain) and a catheter in my dick. Some of the most unpleasant things I've experienced in my life.

I was in the ICU for 2 days. Upon getting out I took more MXE the next day. I know, I know. Anyway, I took some phenibut prior to dosing, and a few hours into the trip I began to experience uncontrollable twitching. I called my girlfriend in panic, fearing that I had developed early onset Parkinson's disease. The twitching was really that intense. My girlfriend came over at 4 in the morning and began to calm me down by taking deep breaths. I was still very stimulated and so took a benadryl. About 30 minutes later, the twitches returned in even greater intensity than before. My girlfriend was scared and so I was I; she sat up and began petting my face and hair trying to help me stay calm.

It's at this point that she says I began frothing at the mouth and having a seizure. I woke up once again to paramedics and had to walk to the ambulance and go to the hospital again.

Overall a totally fucked learning experience.
 
Never Knows Best said:
Disclaimer and warning - READ THIS:


Neutral / Suspect / Safety especially dose dependent

  • Alcohol (warning: dangerous breathing depression in higher doses - dizziness & vomiting possible from moderate dose)
  • dextroamphetamine (MXE taken at tail end of experience)
  • methamphetamine (taken at tail end of MXE experience)
  • others amphetamines
  • aMT
  • GHB
  • Acetaminophen (APAP) / Paracetamol - seemed safe at first but is it truly?

Unsafe / (Potentially) Dangerous - due to potentiation or negative interaction

  • DXM
  • MDAI / MDMA / the more serotonergic the stimulant the worse it may be?? Still a big question mark though.
  • Tramadol (NMDA receptor activity)
  • Methylphenidate
  • Opiates (potentiation of CNS / breathing depression)

Previous Thread
Big & Dandy Thread

So what else have you guinea pigs discovered in the name of science?
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Hmmm, interesting...

I've only just discovered this thread, but if I had seen it before trying MXE I probably wouldn't have dared to, due to the above list of 'not recommended' combinations.

When MXE was first released, I posted a question regarding its safety in combination with opiates and alcohol but got no response - probably because no-one knew at that time.

So I became somewhat of a guinea pig myself, and am glad I did because if I had, I would probably never have dared to try it! I have had some amazing experiences with MXE - every one of which I was also under the influence of my daily maintenance dose of 60mg methadone, rather a large amount of alcohol (350 - 700ml vodka) and quite often some heroin on top.

Now I'm not advocating these combinations, and I can see the possible risks associated with respiratory depression etc, but if one is used to these substances then I don't think that throwing MXE into the mix is particularly any more dangerous than the opiates/alcohol themselves, either alone or in combination. I have not experienced any significant worsening of respiratory depression when using MXE with opiates, alcohol, or both.

Obviously, an opiate naive user who has dosed on opiates, or someone who is absolutely paralytic drunk should avoid MXE, but the same can be said for most other drugs as well. To be honest, it was the reported opiate like activity which attracted me to this substance in the first place, but unfortunately I found this opiate activity to be somewhat exaggerated (though it does tend to constrict the pupils somewhat - which was a surprise when I first looked in the mirror as it definitely has psychedelic effects, and I always associated 'tripping' with dilated pupils).

Is MXE actually regarded as a CNS depressant? If so, then it is never wise to mix CNS depressants unless very tolerant, but I found the stimulant effects of MXE actually counteracted the sedative effects of the other substances enough to give a very nice experience indeed!
 
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Can someone please elaborate on the "dangerous" combination of w/ Tramadol? I've skimmed the wikipedia page about NMDA receptor antagonists to try to understand how MXE works....but I still don't get it. Anyway, what is it about Tramadol that may make it "bad" to use with NMDA receptor antagonists? Does Tramadol release serotonin? Let's also add that I only take tramadol in doses of 50-100mg at a time. I am also on like day 4 or 5 of getting off of Prozac (10mg/daily) am I going to be okay?
 
not even if it's small doses? some guy in a previous thread said it was great for marathon sex or something

also, can this drug interfere with birth control? just thought i'd ask

I don't recommend using when one has taken dextroamphetamine or Adderall because it's turned me into an anxious mess later in the day, even after smoking pot. ugh.

Use the edit button to add onto your posts in the future. Thank you.

~Never
 
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Took 50mg of diphenhydramine last night to help with sleep after doing MXE all evening. It did feel potentially dangerous for some reason, but I'm not specifically sure if it was actually dangerous. Anyway, it helped me get to sleep and I'm fine now.
 
I use diphenhydramine for sleep every night in doses of about 150mgs, I recently used MXE nightly for about 1 and a half weeks and used Diphenhydramine to help me sleep after every single time and had no worrisome side effects. I did notice that If the MXE was dosed late in the night and in a higher dosage the insomnia caused by still having MXE active in my system would overpower any effects that the Diphenhydramine would offer.
 
I find that mixing ketamine and mxe at the same time isn't really anything special. It just taints the k and also gives me angry and depressed emotionsduring the trip and come down which neither has done to me on their own during the tons of times I have done them. Although If I do mxe and wait to I have pretty much completely come down and take a nice dose of ketmine it really ads a nice twist to the ketamine trip. I really want to try mxe+dmt. I would imagine it would be nice considering how amazing ketamine+dmt is like.
 
I've experienced SS symptoms from mixing a even a tiny bit of MXE and molly (done it twice, the second time was completely unintentional). Definitely not fun.

What do you guys think about 4-MMC and MXE? Is it too serotonergic, or would it be safe in small doses (of either or both). Anyone with experience? Thinking about doing it for a concert tonight.
 
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