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Dissociatives [Methoxetamine Subthread] Combinations - 2nd experiment

Definately steering clear of MXE + alcohol from now on, a few drinks is real nice but one drink too many and getting in that naseous head spinning state is absolutely horrible. Plus it gives a way worse hangover than the same amount of alcohol would on its own.
 
Isidor said:
5-apb + MXE = Black-out + vomit ... this was not at very high doses (but with no tolerance). Black out/unconsciousness didn't last very long but I suppose there could be some risk of drowning in your own puke. Of course now I know not to mix serotonine-releasers with MXE.



On alcohol + mxe: I had been having 3-4 beer + mxe quite a few times before and didn't quite foresee the consequences of mixing larger amounts of alcohol with it. Huge mistake... We were having a party at my place and I happened to mention I had some MXE and some friends of a friend immediately wanted to buy some (they had used it before). So I bring out the bag ... and of course now everyone wants to try! This was late in the evening/early in the morning after a long night of drinking and everyone was majorly drunk (including myself). I end up splitting 500 mgs between 9 people (including myself). Most had really bad experiences, a majority of the people threw up, and now everyone thinks mxe is some kind of poison...


MXE + nicotine: I feel very little effect of nicotine and nicotine cravings almost entirely disappear.



Cannabis + MXE: Some definitive synergy going on, but will need more "research"...
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How do I say this nicely, are you serious? Do you realise if you and your friends continue to behave like that, one way or another, very bad things are going to happen, you'll be begging to die just so its over already. Don't give powerful experimental drugs to people who don't even know what the hell it is! and if you choose to do it because you've educated yourself, titrate your dosage up slowly from the smallest inactive levels, take your time, you've got your whole life to explore new molecules and ever greater experiences that way. Or you can kill yourself and your friends, its all in a moment's choice.

Alcohol is so destructive I don't see how anybody that gets drunk frequently can be capable of controlling themselves and should just keep to getting drunk and stay the hell away from anything else, large amounts of alcohol are dangerous to mix with ANYTHING, including life.
 
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I took 20mgs of 2ci, with 2 small (15mg) bumps or mxe toward the end, after i had peaked from the 2c. Went together really well, and helped with the comedown off 2ci. Went from a very silly, goofy evening to a more introspective night with some deep conversations with a good friend. Very enjoyable for me.
 
IMO the comedown from MXE makes a great lead in to another psychedelic. Try taking 50mg of MXE at 2:00PM and then 25mg of 2c-b or some molly at 8:00 or 9:00. Smooth like silk.
 
Had shrooms again the other night with some Mexy.
Was kinda confusing.

I didn't hit enough shrooms.
It was like threshold. I didn't get any visuals at all but I could feel the shroomy body high and the shroomy confusion.
Also the confusion of the MXE.

Made for an interesting night full of thought in bed without sleep.

It was very hard to get to sleep and kinda boring, to be honest.

From now I need to make sure I munch a shitload of mushrooms when I eat them so I get some good ideas. lol
Forget being afraid of them.
DXM & MXE was intense.
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Lol you guys crack me up in here.
Everyone here just does some drugs and then they are like "Yup, I did that it was cool."
lol

Nobody wants to share their tripness with me. 8):p=D

Is everyone in here getting old or too cool to talk about what happens to them when high or what? Geez I go gonzo and see all kinds of stuff and get all kinds of crazy thoughts.
You guys do drugs and we get a "woot" and thats it. lololol
I don't know how you do it.

C'mon guys need to open up around here tell me what happened to you. lol
Tell me how your rainbows bent my brother.

Most people tell me they can't even explain what happens to them when they trip out.
I got like massive amounts of details I want to share with people when I get high.
Lol nobody wants to hear it from me.

You guys just wanna be like "Yup I got high!"

Tell me what happened mang! How was it intense?! Were you holding your balls to the wall wishing you didn't take so much or where you grinding your teeth off or what? haha

I've never had any DXM but I keep hearing it's pretty interesting stuff.
Mixed with MXE you must have had a crazy time!
 
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yeah this thread is surprisingly quiet. although saying that MXE is enough on its own,
 
Could a moderator or OP consider updating the original post's list? MXE + LSD still isn't listed there. Should be under Neutral if someone is aware of how strongly they potentiate each other, or under potentially dangerous if the you consider it renders someone pretty much incapable of taking care of themselves or being able to respond to their surroundings.

My post is on the 2nd page, and nothing on the first page mentions MXE + LSD, so someone just checking the list may not realize there are reports of the combination that are unfavorable.
 
veeELLKAY said:
...thinking my keyboard was a borough of New York.
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That tops my list for "most succinct and entertaining description of psychedelic/cosmic insight." Thanks for the laugh. BTW, which borough? Gotta be Queens, just cuz a keyboard has such a bland personality relative to, say, Brooklyn.
whynaught said:
I don't understand why serotonin releasers can't mix with mxe? Does mxe effect serotonin heavily or something?
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MXE has weak serotonin reuptake inhibition activity; this kind of thing is heavily dose-dependent. You can die from too much of a releaser OR a reuptake inhibitor if you take enough; the combination of the two just means that more serotonin is being dumped into the space between synapses while there's an inhibition on the ability of neurons to reabsorb (reuptake) that serotonin, hence you build up too much IF you take too much of either or both of the substances.

Each person has a unique response!!! I nearly died from being on 5mg per day of citalopram and 100 mg a night of trazodone; 2 days after I stopped taking the trazodone and a day after I stopped the citalopram, the serotonin syndrome was getting progressively worse because of the very long half-life of citalopram (as is the case with all prescription SSRIs.) I was taken to hospital by ambulance 2 consecutive days because the first day the ER (A&E in the UK) docs didn't believe me when I said I had serotonin syndrome even though I had extreme horrific symptoms that fit well. Next day I nearly died from a massive seizure and concussion, then was unconscious for a few days.

OTHER people may take 5 times as much citalopram just to get any benefit from it. Some people can even take a potent serotonin releaser like MDMA while they're on an SSRI and it doesn't seem to have much effect. I've read reports that this combo actually just kills the MDMA buzz but I don't understand how that works.

The long and short of it is that any experimentation with potentially dangerous combinations (and most combinations are potentially dangerous) should be tried at very low doses to start out. Ideally, anyone using drugs should have the ability to monitor their blood pressure. A monitor costs only about $25 (US) and it's well worth it. One of the first signs of serotonin toxicity is serious hypertension, which also results from too much dopamine and/or norepinephrine, anxiety, and other factors that play into drug use. Have blood pressure meds on hand if experiments show that you risk a hypertensive crisis. You can have a stroke or other severe consequences if BP shoots way up and stays too high.

It is also a very good idea to have benzodiazepenes on hand, preferably alprazolam, lorazepam, or diazepam, and use them if anxiety and/or BP spikes occur. Benzos, used infrequently and in moderation, are among the safest and most useful drugs around. They are used for treating acute serotonin toxicity along with drugs that are only available in hospitals. Their usefulness lies in their ability to quickly help calm you down, they're inhibitory in their action which helps slow down neuronal activity in general, and they help stop the amplification of blood pressure spikes by calming the self-reinforcing tendencies of overactive CNS response. And, worst case scenario, a benzo will just calm you down even if you don't need it; for some people it enhances certain highs, smoothing things out.

My feeling is that many of the potentially dangerous drug combinations, including those listed in this thread, can be made relatively safe by lowering doses. If safe doses don't give satisfying results then try a different combo or go for a nice walk with friends while sober. ;o)
 
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thanks for the info on the benzos, didnt know that, i use them a lot with MXE to smoothen the trip out and get me to sleep, they seem to compliment it so well,

had some very nasty effects from mixing this stuff with serotonin effecting drugs, dont recommend it. strangely once or twice ive had mild brain zaps after a night of MXE, but they werent the usual ones like i get from MDMA, so i assume it does effect serotonin in some way, even though some people keep on claiming it doesn't effect serotonin
 
5 mg propranolol (a very low dosage of a beta-blocker) combined with MXE works well for me, as it did with DXM.

It negates the pounding, racing heart effect for me, which makes the trip much more smooth and calm. Based on what I've read, I'm fairly confident that this is not a dangerous combination at such a low dosage of propranolol.
 
T:00:00 - 13mg 2C-P
T:06:00 - 25mg MXE
T: ???? - 42mg MXE
T:14:00 - 38mg MXE

This got me extremely high, but wasn't good for my heart. I wasn't in good shape, and had partied earlier that week, so perhaps I wasn't properly recovered. Especially since, according to this thread, almost all 2C-X/MXE combo's have had positive reviews.

Note that the MXE brought back the 2C-P effects quite a lot. The first 25mg was supposed to add a little more euphoria to the "2C-Prolonged" experience, because I found it more mentally tiring than I had anticipated. Instead it got it back to full-on peak. For some reason I kept redosing, the 42mg (yes, HHGG dose) to somehow sustain the effects, I suppose, after I realized I would go tripping into the next day. 38mg because I was drawn to the hole. Holing on the tail of a 2C-P experience was quite taxing though, and I came out of the hole with little life force left. A mentally dark place.

I might repeat the 2C-X/MXE combo, but in better health, and not with the P variety of 2C.
 
Good:

MXE & Butylone: Probably my favourite MXE combo, can go either way though, Butylone is probably one of the best stimulants for mixing in my opinion, goes really well with dissociatives. I find it hard to describe particularly well, but the psychedelic effects of butylone just seem to enhance MXE, while the stimulant effects seem to intensify it. That said it could go either way, I had some of a shit batch of MXE a few months back which didn't mix well at all. I've taken to having a break from this one for a while though, mainly cos I'm bored of butylone in general.

MXE & Alcohol: Hmmm, I really like this one. Gets me really quite drunk quite easy, very lairy but in a happy way not an attitudy way. Not that I'm much of a drinker.

MXE & Etizolam: Probably any benzo will do for finishing the night off, I find the tail end of MXE can be a little difficult to get to sleep off and these really help.

OK:

MXE & Ketamine: Not really that special, although the shear lack of K round these parts means I haven't really explored it too much, however MXE definitely makes shit K better.

Bad:

MXE & Ethylphenidate: Seems to a fair job of suppressing dissociatives, I wouldn't personally describe it as horrible, just kinda shit and annoying, I just felt kinda dumb more than anything.


Can't really think of any more right now, but I tend to find K brings out the best in a lot of other chems and MXE doesn't seem too different in that regard.
 
wouldnt mix them, MXE is fucked up mixed with stimulants, infact its fucked up mixed with most things
 
MXE + alcohol doesn't deserve a (partial) place in the "safe" category, in my opinion. If only for the kidney load that's bigger than the sum of the load of its parts. There's also noticable rhabdomyolysis, in my experience. Not to mention any synergy quickly disappears beyond threshold levels of alcohol.

Also, why put a drug in the safe category as well as in the dangerous category, if there's a "safety dose dependent" category in the middle?

(MXE + alcohol even has a death count by now (two guys drown in a pond). Though this wasn't a direct result of the pharmacological interaction.)
 
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MXE + lots of alcohol is a fucked up combo, never again. did it quite a few times in the past, shouldnt have done it
 
I know it's probably not too safe but low dose opiate + low dose MXE is a very good combo. Low dose MXE + Dihydrocodeine in particular is very euphoric. The MXE adds the euphoria that the DHC lacks and turns it into a very nice opiate high. I wouldn't recommend this combo unless you have a tolerance to both opiates and MXE.

Klonopin + MXE is pretty good too but it tends to be hit and miss for me. Sometimes the Kpin just seems to dull the MXE trip but other times it smooths out the rough edges of MXE.
 
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