mephedrone long term negative effects progress reports

[enduin]

Btw as an update those "palpitations" I talked about showed up a couple days after I posted (I know it's fucking odd), and repeated randomly in the last week.
I still noticed that they are likely to go back to normal after eating my daily arginine supplementation (before bedtime). Weird.

Also I noticed that tramazoline is an adrenergic agonist, so it's likely that the "supposed upregulation" involved adrenergic receptors like vektor said and not 5-ht ones.

 

[vortex30]

Since the start of the New Year my Mephedrone use has been as follows:

3 day binge mid-January

1 night on the stuff late January

2 day huge binge early February (5 days before the doctor's appointment)

I've probably used 6-8g or so over these 3 'sessions'.

I had a doctor's appointment last week and my blood pressure was 140/90, whereas I have always been up to a year ago when my last check up was and when I first started taking Mephedrone a healthy 120/80. I even stupidly had 200mg a few nights later...

Done, done, done now. I didn't quit smoking cigarettes to have my long-term health compromised by this nasty shit.

 

[MikeHawk]

Since the start of the New Year my Mephedrone use has been as follows:

3 day binge mid-January

1 night on the stuff late January

2 day huge binge early February (5 days before the doctor's appointment)

I've probably used 6-8g or so over these 3 'sessions'.

I had a doctor's appointment last week and my blood pressure was 140/90, whereas I have always been up to a year ago when my last check up was and when I first started taking Mephedrone a healthy 120/80. I even stupidly had 200mg a few nights later...

Done, done, done now. I didn't quit smoking cigarettes to have my long-term health compromised by this nasty shit.

Well this is certainly interesting and important information. This could potentially be clear evidence that Mephedrone is toxic even in small quantities. We need more BP readings from people who use this stuff.

 

[nolys]

i thought meph was supposed to be fine when it came to blood pressure?

 

[MikeHawk]

i thought meph was supposed to be fine when it came to blood pressure?

From what I've read it appears the bluing is not correlated with anomalous BP. This doesn't mean that long-term abuse cannot lead to increased BP. The 5HT2b agonism could potentially cause cardiovascular issues such as those described in his post.

Still, there's not enough anecdotal information to draw any real conclusions yet.

 

[vecktor]

i thought meph was supposed to be fine when it came to blood pressure?

if ephedrine is anything to go by then excessive and prolonged mephedrone use will have serious chronic effects including enlarged heart, increased blood pressure, kidney damage etc etc.

I have pretty much given up posting about this, nobody pays the slightest bit of attention and just continue to fuck themselves up.

 

[vortex30]

Well this is certainly interesting and important information. This could potentially be clear evidence that Mephedrone is toxic even in small quantities. We need more BP readings from people who use this stuff.

Well I better clear this up, that isn't my life-time Mephedrone use, that's just since the New Year when I 'cut back' but really still used Mephedrone more than it should be used. I have 10 months of once a week use, sometimes lasting 2-3 days before the New Year. I've certainly over-used this one for about a year now.

vecktor - When you say chronic, do you think the fact that my blood pressure was 140/90 5 days after a binge may last well into my future? Even if I take the steps I'm currently taking of:

Cutting back on drugs big time, especially stimulants, NO Mephedrone/sketchy RC stimulants

Exercise, focusing on cardio work outs

Getting full nights' sleep regularly

Healthy diet high in vegetables, fruits and protein/vitamins, not excessive in any way of eating fatty/processed foods (though I do from time to time of course)

I'm only 20, I'd be damned pissed off if I've done irreversible damage... AFAIK, it is common/normal for athletes to have big hearts, so if I were to just take up an active lifestyle (quite natural for me, I've only been inactive for 2-3 years, always was active as a child), this should become less of a concern as my body will have use for this excess heart muscle? I sure hope I can turn this all around...To be honest, this concern is probably a blessing in disguise, I've learned a lot about the importance of good health and respecting my body through abusing Mephedrone.

 

[MikeHawk]

I know this doesn't really fit in with the rest of the thread. But I've noticed that I have an almost permanent feeling of bronchodilation. My resting heart rate is also a lot lower than I remember it to be. I'm not sure if this is because I've discontinued Mephedrone or if it's done something unusual to my heart.

 

[nolys]

I know this doesn't really fit in with the rest of the thread. But I've noticed that I have an almost permanent feeling of bronchodilation. My resting heart rate is also a lot lower than I remember it to be. I'm not sure if this is because I've discontinued Mephedrone or if it's done something unusual to my heart.

are you doing any running or gym training? or have you stopped smoking recently?? that could be th cause

 

[MikeHawk]

are you doing any running or gym training? or have you stopped smoking recently?? that could be th cause

I've been doing pushups every other day however I didn't expect such radical results. I've only been doing it for a week and a bit. Being able to completely satisfy my thirst for oxygen in one fast breath is really pleasurable. I think working out combined with no Mephedrone has made the results more obvious.

 

[nolys]

I've been doing pushups every other day however I didn't expect such radical results. I've only been doing it for a week and a bit. Being able to completely satisfy my thirst for oxygen in one fast breath is really pleasurable. I think working out combined with no Mephedrone has made the results more obvious.

yeah thats probably your reason then the working out has made your body realise it needs to work at a higher level to satisfy your oxygen needs + the mephedrone has mabey worn out of your system making you feel fresher and fitter?

thats my opinion anyway :D

 

[Dondante]

I'm only 20, I'd be damned pissed off if I've done irreversible damage... AFAIK, it is common/normal for athletes to have big hearts, so if I were to just take up an active lifestyle (quite natural for me, I've only been inactive for 2-3 years, always was active as a child), this should become less of a concern as my body will have use for this excess heart muscle? I sure hope I can turn this all around...To be honest, this concern is probably a blessing in disguise, I've learned a lot about the importance of good health and respecting my body through abusing Mephedrone.

You'll be fine if you cut out mephedrone and keep use of less toxic stimulants to a minimum. However, I'd recommend cutting out all stims at least until your BP returns to normal.

The effect of NE-releasing stimulants on heart is that they often cause cardiac muscle hypertrophy that out paces the ability of new blood vessels to form. If prolonged, this may cause small areas of ischemia, leading to contraction band necrosis, a common finding in chronic cocaine users...and likely chronic mephedrone users as well. The mild cardiac hypertrophy that occurs in some athletes is completely benign because normal physiologic processes result in muscle enlargement, and there is no corresponding pathologic increase in blood pressure.

 

[vecktor]

^ thanks for posting that, saved me having to post

 

[PerfectBlue]

Hi guys,

Firstly, could I say thank you to Vecktor. Whilst you may not feel that people appreciate your advice, having followed the thread I value your thoughts on the topic.

I personally have my own worries about Mephedrone use. About a week ago I checked myself into A & E after experiencing a very high heart rate, chest pains, a tightness (which I now recognise as vasoconstriction) down my arms and a feeling of pins and needles in my face. Upon arrival I received an ECG which showed normal signals and also a blood test and chest x-ray.
Since then the chest pains have subsided, though I still have the occasional pain at my fingertips or in my hands, and I'm incredibly paranoid about the potential damage I may have done to myself. I'm hoping deeply that this may be psychosomatic, as I have read a number of long term symptom and side effect threads, and the talk of it being a 5-HT2B agonist or causing irreversible valve damage scares the shit out of me.
Aside from shooting pains, I have felt occasionally light headed. If these persist then I'll try and get them checked out, but I have no idea how they would be able to check for heart damage besides the test I have already had. I'll be sure to update with BP readings if so.

 

[toocoolforschool]

yes there is such thing as clean meph now how the hell do i clean this shit?

Used mephedrone once, around 400mg in January; two bombs and a line. Had a blast, drank a lot with it and smoked cannabis too.

Started noticing heart/chest weirdness the next few days, combined with dizziness, fast and then slow pulse and things. The chest "tension" and the feeling that my heart was closer to the surface to my chest continued for several weeks, in some ways it's never completely disapeared, especially if I hammer stimulants I can feel it a little bit. At the time it was pretty scary, I was getting anxiety too and finding it hard to go to sleep. I noticed it got worse at night, and it inspired me to try and go to bed earlier, as well as to drink less and to stop smoking cigarettes (mostly).


I don't feel like i've done serious serious damage to myself, but 8 months later I still feels like i'm feeling the repercussions of meph use.

I have used the substance three times all from the same supplier the first two times there were no ill effects and i was able to sleep in about an hour and a half the third time it was different. quite similar to the expierence mentioned above. the expierence lasted 40hrs+ and honnestly im still not completly "normal" yet

deffinantly changed my life style but i'm stuck with 3 grams of this dirty stuff.
has any one had any sucess cleaning dirty meph? and what would one sugest for a house hold chemest to try and atempt this?

 

[enduin]

Hi guys,

Firstly, could I say thank you to Vecktor. Whilst you may not feel that people appreciate your advice, having followed the thread I value your thoughts on the topic.

I personally have my own worries about Mephedrone use. About a week ago I checked myself into A & E after experiencing a very high heart rate, chest pains, a tightness (which I now recognise as vasoconstriction) down my arms and a feeling of pins and needles in my face. Upon arrival I received an ECG which showed normal signals and also a blood test and chest x-ray.
Since then the chest pains have subsided, though I still have the occasional pain at my fingertips or in my hands, and I'm incredibly paranoid about the potential damage I may have done to myself. I'm hoping deeply that this may be psychosomatic, as I have read a number of long term symptom and side effect threads, and the talk of it being a 5-HT2B agonist or causing irreversible valve damage scares the shit out of me.
Aside from shooting pains, I have felt occasionally light headed. If these persist then I'll try and get them checked out, but I have no idea how they would be able to check for heart damage besides the test I have already had. I'll be sure to update with BP readings if so.

Relax man, being paranoid and anxious will only worse your problems. If you've been checked it means there's nothing serious going on with your heart, meaning you are not gonna die. Stop any stimulant, eat healthy, exercise and be patient, it'll go away or improve greatly over time. This is the mantra any new guy panicking because of meph side-fx is being told. You can take some arginine supplement if you feel you still have vasocostriction, it helped me somehow.

 

[geebiequeen]

well i have stupidly took ridiculous amount over past 3 weeks im talking about every day and last few days i stopped taking it i have 3 numb fingers i can harly bend and are a bit swollen on my left hand thats dont seem to be getting any better its only been 3 days , do you think it will clear on its own? also is ther anything i can take to make it go quicker its really scaring me...ive read that magnesium supplements and L-arginine can help have u heard of this?

 

[enduin]

Relax man, arginine can help with vasocostriction, and avoid any kind of stimulats from now on. It'll go away eventually, but hope this served as a lesson for fuck sake!

 

[blobbymahn]

One thing I noticed after some serious Mephedrone abuse was a pretty swollen throat.

If I pressed down on my adams apple, I could feel it squelching about. This went after about 3-5 days of abstinence.

Anybody else get this?

Seconding the high blood pressure too. For about a week or two after Mephedrone I'd have stage 1 hypertension, about 150/90. Usually it's around 120/60. Pulse rate wasn't effected after, but when intoxicated it lay at 130bpm, normally 60.

Been a pretty heavy user, 1-3g a weekend for the last year or two. Noticed I was getting cravings through the week, so given up now. Perfectly in time with the UK ban too.

 

[melange]

check for hyperthyroidism