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mephedrone long term negative effects progress reports

vecktor said:
all interesting.
I suppose analysis of commercial mephedrone is required gc should separate the isomers reasonably well.
V
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Indeed, I would be interested to see that GC trace. Hopefully it doesn't look like a pine forest :)
 
melange said:
the problem may not lie with the drug, but with the ridiculous doses most of these people are taking


people talking about grams and grams in a few days
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I have to say that's probably where the problem lies.

Everything in moderation.
 
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I have taken it a handfull of times, never exceeding 350mg (always oral) in an entire 24hr period. I never had an serious negative reactions to it, but at higher doses, there was some minor adrenergic annoyance a few hours after dosing (sympathetic nervous system activation, much like a lot of ephedrine or one of those adrendoceptor agonists from an asthma inhaler...which is not surprising, as 4-methyl-ephedrine is a major metabolite of mephedrone).

Has anyone seen a serve vascular inflammatory recreation emerge after taking a single normal recreational dose, say 250mg orally? If so, then I presume that a certain small percentage of people have an autoimmune hypersensitivity to it. For them, it must trigger some form of vasculitis (massive inflammation of vascular tissue), which is then attacked (overzealously) by the immune system, which itself is subsequently weakened from the whole hyperallergenic clusterfuck. The thing about idiosyncratic autoimmune reactions is that they are usually (1) genetically determined and (2) catalyzed by a metabolite of the drug, not the drug itself.

For example, a drug that I take every single day, lamotrigine, can, in certain rare hypersensitive individuals, cause an autoimmune reaction called toxic epidermal necrosis--in which ones' skin gets massively inflamed, rashy, vascularized...and then dies and falls right off.
 
think im gonna give this shit a break, did my usual amount last night and barley felt anything, which is strange as i usually end up feeling pretty good at least, only eye wobbles etc on higher doses
 
^curious to know what's happening when you get the eye wiggles? I've experienced them as well while on drone, what physically is going on here?
 
All I can think really is that whilst stimulated the eye muscles flex/tighten like the jaw and eventually become tired, then you relax them and they just kinda 'wiggle' haha. I really am not certain, but the eye's version of gurning makes sense to me. Its really just a matter of relaxing your eyes though. I can sorta do it when sober. They don't wiggle a lot just I can feel a little want to.
 
Used mephedrone once, around 400mg in January; two bombs and a line. Had a blast, drank a lot with it and smoked cannabis too.

Started noticing heart/chest weirdness the next few days, combined with dizziness, fast and then slow pulse and things. The chest "tension" and the feeling that my heart was closer to the surface to my chest continued for several weeks, in some ways it's never completely disapeared, especially if I hammer stimulants I can feel it a little bit. At the time it was pretty scary, I was getting anxiety too and finding it hard to go to sleep. I noticed it got worse at night, and it inspired me to try and go to bed earlier, as well as to drink less and to stop smoking cigarettes (mostly).

I had an ECG (all was pretty normal) and a couple of check ups and the very first one (maybe a week after meph use) my doctor thought he could hear a slight murmur with my heart. It seemed to have faded another week after that though. Ever since the meph experience I have had these red blotchy spots on my chest.... centred around my nipples and also two quite prominantly in the middle of my rib cage, at the top and towards the bottom. They really haven't faded at all since January,and one to the top right is darker red. I've never posted pics of this, but I might.

I don't feel like i've done serious serious damage to myself, but 8 months later I still feels like i'm feeling the repercussions of meph use. Everyone atm is bang on it at festivals and in clubs as MDMA is in short supply. I am maybe one of the unlucky few, but it's enough to put me off the stuff. Never had anything like this from a drug before, I am only 20 and young and heart worries are not something i'm keen on! Fuck that! I do still take drugs and stimulants n feel pretty fucking healthy generally, but I do slightly worry quite WHAT mephedrone did to me, and if anything's changed, n why those blotchy spots are still there. Will I still have them at 60? Have I damaged my cardiac system irreparably? Who fucking knows, I am still living life, and I don't actually regret trying mephedrone, despite the issues. It's just one more thing that faces me in life now....
 
I also have been getting anxiety badly since my run in with meph, and strangely enough also notice it is far more prominent at night than it is in the day time. I am still needing to get an ECG, also creatine and other blood tests. I hope someday we find out what we did to ourselves.

I have discoloration on the side of my foot still where I was sitting on it when I used mephedrone. Were you by chance laying down on your stomach when you did mephedrone, with perhaps a matress or something pressing into you? I am wondering if it is some sort of posturally dependent discoloration. I find it strange it is only discolored where there was pressure, although at the same time it is only my foot not on my butt which would be I guess cuz I was sitting down.

Good luck man, thanks for the update.
 
I also took about 400mg of meph in 2 bombs spaced over a night out. Had a wicked time, euphoria, confidence etc. Woke up the next day with chest pains, a numb left arm and proper anxiety. so i'm never touching this stuff again.
However it's almost 2 weeks later and i'm pleased to say that i pretty much feel like my old self again, sometimes get slight tingling in my little finger on my left hand, but apart from that i'm Ok now, no more anxiety or pains. which i am RLLY thankful for. If you've never tried this stuff before be really careful, because it completely fucked me up, i think it's really toxic and my advice is to stay away from it.
 
with mephedrone i dont understand how people are getting nasty side effects and others arent. personally i have sniffed 1.5g in the space of a night, went to bed, had a great sleep and woke up the next day in a good mood with no side effects whatsoever.
can somebody explain why mephedrone seems to give different people different negative effects?
and the blueness of your fingers/limbs is more than likely vasoconstriction in the capilaries resulting in less oxygen getting around your body causing the blueness
 
nolys said:
with mephedrone i dont understand how people are getting nasty side effects and others arent. personally i have sniffed 1.5g in the space of a night, went to bed, had a great sleep and woke up the next day in a good mood with no side effects whatsoever.
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i reckon it could be something to do with the different stuff the vendors are selling. some of it smells weird, some of it has no smell, some of it has bigger crystal lumps, some of it is slightly moist, other stuff is dry as fuck

i guess it also depends on if people are mixing it with other stuff, how much they are doing at once, how often they are re-dosing, how often they take it, the method of consumption,

i used to wake up feeling fine. now (on the same dose, ) i usually wake up feeling dizzy, then the next few days i get a nasty come down which leaves me wanting to curl up and die. no idea why
 
melange said:
sounds like some peripheral vasoconstriction goin on



the problem may not lie with the drug, but with the ridiculous doses most of these people are taking


people talking about grams and grams in a few days
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I had my most serious side effects run in with Meph (puple Knne's, legs, arms, elbow, numb limbs , couldn't breathe properly, very lightheaded, severe headache....could go on) with a dived total dose 450mg. That is not really a big dose. I would say that was pretty average.

EDIT - I should also point out here that this night before taking the Meph I took 200mg Methylone for the very first time ever, Maybe it was the Methyl that fucked me over? IN looked unpure as shit in the baggy and was a clumpy off white colour similar in consistency to flour.
 
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ColtDan said:
i reckon it could be something to do with the different stuff the vendors are selling. some of it smells weird, some of it has no smell, some of it has bigger crystal lumps, some of it is slightly moist, other stuff is dry as fuck

i guess it also depends on if people are mixing it with other stuff, how much they are doing at once, how often they are re-dosing, how often they take it, the method of consumption,

i used to wake up feeling fine. now (on the same dose, ) i usually wake up feeling dizzy, then the next few days i get a nasty come down which leaves me wanting to curl up and die. no idea why
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I think you are on to something here. Different batches from different vendors have had different effects on me. We can't rule out contaminates (deliberate or not) or vendors cutting it to make more money.
 
ColtDan said:
think im gonna give this shit a break, did my usual amount last night and barley felt anything, which is strange as i usually end up feeling pretty good at least, only eye wobbles etc on higher doses
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I've noticed this too. I was doing up to 500mgs every friday (missed the odd couple) for about 3 months and the it suddenly just wasn't giving me the same results anymore? Strange.
 
Don't kid yourselves, this stuff is toxic. It's just that people are different. Some get the side effects from the first time they try it, some may use it a long time with no problems, and then suddenly- bang, you have purple knees. And from the reports I've read, manufacturers and batches don't seem to have anything to do with it. Some people have friends doing from the same batch with no side effects, then their frends give them the meph and they get blue knees.

Until some serious research is done on this substance I would advise everyone to stay far away from mephedrone.

And very probably after that research as well.
 
...I wouldn't really be all that surprised if this stuff is a strong neurotoxin, too.
 
at this stage its too hard to tell what effects it has on the human body and also why it has those effects....we are the guinea pigs and anything that will be researched on mephedrone will come from our experiances and the effects it has on us. it will be at least 10 years before there is any hard evidence on the short + long term side effects of taking this drug. for all we know we could be shortening our lives every time we take it... we could be developing mental illnesses, we could be being poisoned and not even know. this is the danger with mephedrone and all other designer drugs. take it at your own risk
 
ive had a few weeks break, definitely feeling better for it. energy levels are much higher, don't feel so shit all the time. my emotions felt fucked up for ages. this stuff is hard on the body for sure. started getting paranoid i was going to get purple knees etc, fuck that

a word to the wise, if your going to take it, don't take the stuff that smells. its bad, it gave me a strange heavy heart beat which lasted for days. ive found the stuff that doesn't smell strange doesn't make my heart race as bad.

whatever the stuff is in the smelly batches, is probably some very nasty stuff
 
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