mephedrone long term negative effects progress reports

[Burn it up]

Apparently mephedrone is non neurotoxic [1][2].

Regarding if it is "worse" for you than meth or amp it all depends on the consumption pattern, though it seems to have some concerning peripheral effects at high doses or chronic use.

And yes, it is fun.

 

[klfiend]

Your articles states that mephedrone is not neurotoxic to dopaminergic neurons. I would still wager mephedrone bitch slaps the serotonergic neurotransmission system.

 

[MagickalKat777]

Your articles states that mephedrone is not neurotoxic to dopaminergic neurons. I would still wager mephedrone bitch slaps the serotonergic neurotransmission system.

As would I, especially since mephedrone brings out the brain zaps just like SSRI discontinuation syndrome and over doing MDMA.

In regards to overall toxicity, 4-methylephedrine is pretty bad for your heart and its the primary metabolite of mephedrone if I remember correctly.

On the same token though, mephedrone leads to binging like no other... I mean I went on multi-day binges with the stuff when I had pretty much unlimited access to the 99% cylinder crystal that was going around. In that respect, it was less of an overall effect than MDMA as I would have been in a world of hurt very quickly with too much MDMA.

 

[EarthBounded]

4 Years clean off Mephedrone myself, I ingested about 14 grams within a month or two which was pretty low compared to what I saw others taking. The side effects hit about a month after I quit and lasted for one year it was fucking awful, I can see how someone would actually kill themselves after to much drone.

After 4 years I feel zero side effects remain

 

[Originaldetangler]

This is such an old thread, so no idea If anyone will reply . Been using mephedrone for the last year about 3 times a month. Bombing 200mgish a time probably getting through a gram Initially cos was the nicest feeling I had ever experienced , and it still is , but then started to experience palpitations and panic as the drug was wearing off. . My HR would go up to around 100bpm so not crazy fast but would get worried and also seemed to correspond with really tight stomach bloating . I wonder if bombing was causing the stomach upset and that was contributing to the palpitations. But also just a real belief that I will die at that moment . Altho no chest pain or breathlessness , just a dread and palpitations.
Also sort of feel like I'm now super sensitive to stims. Altho have had ekg and doctors visits and everything is fine . Most likely thing is I've just exacerbated my existing anxiety, but have this preoccupation that I've sort of given myself some sort of heart problem. Has anyone had any experience of directly related heart issues from mephedrone use ?
The memory thing too I get.
My other feeling is that prolonged meph use just messes with your head and makes you a sort of hysteric hyperchodriac .
I mean now I just sit around googling "mephedrone + palpitations " or "mephedrone + panic " .
Has anyone experienced anything similar? It used to be perfect when I did it . No real comedown, would be able to be social. But then I spose in lockdown it became more of a thing where would do it with my gf and think you tend to redose more with other people! And feel like once it started to make me worry it's just game over for it . Hopefully this makes some sense, I'm quite tired !

EDIT :

I've had periods of obsessively worrying about my memory before so I could imagine this is just anxiety. I spose the only thing is the palpitations, which I've never had from stims before. Or at least ever like meph. Not even wild ones , just the fact that they sort of come on with a sense of dread when I'm sobering up. Lots of sort of 7am quielty drinking a cup of tea whilst my gf speaks in soothing tones . They're made better completely by 5mg of valium but always worry about mixing stims with valium

 

[plumbus-nine]

but then started to experience palpitations and panic as the drug was wearing off. . My HR would go up to around 100bpm so not crazy fast but would get worried and also seemed to correspond with really tight stomach bloating .

This is from a metabolite (4-methylephedrine maybe), with 3-mmc it's even worse.. like an overdose on nasal decongestants. Might be possible to directly antagonize the effects with an alpha blocker or even clonidine but my last time mephe is years ago - I liked it as much as I hated the after effects so switched to another, very addictive and possibly toxic drug class, the dissociatives..

 

[Zephyn]

Ten years later and im still not right. There was maybe 6 years i felt decent in between, but then I met other hard-core stimulants, but I bet I'm more prone to the side effects from them from my mephedrone days, I spent at least 4 years, 2 of which were very bad,, seriously suffering from mephedrone abuse

 

[Originaldetangler]

This is from a metabolite (4-methylephedrine maybe), with 3-mmc it's even worse.. like an overdose on nasal decongestants. Might be possible to directly antagonize the effects with an alpha blocker or even clonidine but my last time mephe is years ago - I liked it as much as I hated the after effects so switched to another, very addictive and possibly toxic drug class, the dissociatives..

I had been just telling myself it was anxiety because it didnt used to happen and seemed to correspond with when I became more anxious in life, but this sort of worries me and def puts me off trying it again. Hope I havent wrecked my heart . Can never tell how afraid of palpitations to be .

I had been just telling myself it was anxiety because it didnt used to happen and seemed to correspond with when I became more anxious in life, but this sort of worries me and def puts me off trying it again. Hope I havent wrecked my heart . Can never tell how afraid of palpitations to be .

I mean cos it didnt used to have that effect, hence why worrying I've ruined myself somehow . Altho also might have just been using less beforehand

 

[Ganjcat]

Just putting this question out their for my own curiosity it might also help it might also sound a bit weird but have any past or present mephedrone users had any trouble with a painful stinging sensation when peeing? Or just not being able to go and peeing causing some sort of pain since using this drug?

 

[Tramalala]

This is such an old thread, so no idea If anyone will reply . Been using mephedrone for the last year about 3 times a month. Bombing 200mgish a time probably getting through a gram Initially cos was the nicest feeling I had ever experienced , and it still is , but then started to experience palpitations and panic as the drug was wearing off. . My HR would go up to around 100bpm so not crazy fast but would get worried and also seemed to correspond with really tight stomach bloating . I wonder if bombing was causing the stomach upset and that was contributing to the palpitations. But also just a real belief that I will die at that moment . Altho no chest pain or breathlessness , just a dread and palpitations.
Also sort of feel like I'm now super sensitive to stims. Altho have had ekg and doctors visits and everything is fine . Most likely thing is I've just exacerbated my existing anxiety, but have this preoccupation that I've sort of given myself some sort of heart problem. Has anyone had any experience of directly related heart issues from mephedrone use ?
The memory thing too I get.
My other feeling is that prolonged meph use just messes with your head and makes you a sort of hysteric hyperchodriac .
I mean now I just sit around googling "mephedrone + palpitations " or "mephedrone + panic " .
Has anyone experienced anything similar? It used to be perfect when I did it . No real comedown, would be able to be social. But then I spose in lockdown it became more of a thing where would do it with my gf and think you tend to redose more with other people! And feel like once it started to make me worry it's just game over for it . Hopefully this makes some sense, I'm quite tired !

EDIT :

I've had periods of obsessively worrying about my memory before so I could imagine this is just anxiety. I spose the only thing is the palpitations, which I've never had from stims before. Or at least ever like meph. Not even wild ones , just the fact that they sort of come on with a sense of dread when I'm sobering up. Lots of sort of 7am quielty drinking a cup of tea whilst my gf speaks in soothing tones . They're made better completely by 5mg of valium but always worry about mixing stims with valium

Sorry you got those effects mate. Obviously you should quit doing it for atleast a long time and probably better forever. I don't know why you would be worried about mixing stims with valium though. Ofcourse benzos are addictive in their own right but if you use stims sporadically and then use a benzo for the comedown you should be completely fine. People experiencing a stimulant overdose actually get benzos in the hospital. I'd argue it's better to use a benzo on the comedown than not. The overstimulation from the metabolites are probably giving you the anxiety and putting strain on your heart, valium will prevent a part of that atleast!

 

[Tramalala]

Are you using an old mephedrone batch @Originaldetangler or is there still mephedrone being produced and sold? I was under the impression most of that died down when it got banned. Same for Methylone.

 

[Originaldetangler]

Are you using an old mephedrone batch @Originaldetangler or is there still mephedrone being produced and sold? I was under the impression most of that died down when it got banned. Same for Methylone.

Its allegedly mephedrone ! And recently produced . I've got two sources of what purports to be mephedrone which was using, and both gave me no bother in the slightest until last October when I got palps and a panic attack , and then ever since then I've always had this palpitation / panic thing . Its like everything is fine and then the palps start. But not like sweating or weird breathing. Still feel fairly chilled in my body . Just sort of trembly and palpitationy. Reminds me of the feeling of having done too many blasts on my asthma inhaler . Also seemed to correspond really directly with a change in my stomach, that started the same week in october I got the first panic attack. Not sure if at that point
A) the meph changed (unlikely )
B) I tipping point fucked my heart and mechanism (what I'm most worried about)
C) I had such a traumatic panic attack that the sense memory of it sets off the palps now every time, even when I'm trying to keep calm at all costs . It was a horrible horrible experience the panic attack in October. Was trying to find a room in the flat that I thought would be the least sad for my body to be discovered in, so was just walking up and down the hall on the phone to the doctor and then the ambulance, although when they got there my heart rate was only like 107.


Yeah probably best thing is to lay off for a good stretch / forever , which I'm doing . Don't really like the wonderful mcat experience being concluded with a sort of woozy terror section! Just annoying that it seems to be something that wont work itself out , and probably spells the end of doing mcat for me. Which I spose is no great shame! I think the problem probably was also exacerbated by the fact that I used to do quite small amounts socially. Noone would even know I was on it tbh just a nice warm glow, but then in lockdown got into redosing more. Just a shame cos I feel like I've sort of "ruined it". Altho maybe with things like this you will always reach a point where it's best to knock it on the head !
Maybe I'll try and again with a small amount next winter. Altho I spose maybe I'll find a different way to feel happy and calm and warm and pleasant by then !

 

[Gaffy]

Nuke