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lsd receptor saturation dose? [SCRAPS]

"The complicated mechanism" that people are refering to, might be that of the sensory distortion. Psychedelics tend to not just affect the receptors and the release of neurotransmitters, but also affects the signal in other ways, unusual links between centers in the brain, extreme distortion of the electromagnetic neurosignals and stuff like that. A good theoretical (but complex) explanation can be found in a book called Psychedelic Information Theory, which is an awesome introduction to the neurobiology behind the psychedelic experience. http://www.tripzine.com/listing.php?id=pit_toc here's a link.
 
For my,psychedelics dont make music distorted,they make it very loud,deep,euphoric,detailed,intense and spiritual.If I am sober,music now feels like my brain is sleeping,but on trip,that is so much sharp and alive that no words can describe it.
 
Me neither - psychedelics have never distorded music/auditory input in the way they scramble visual input (never had DIPT though). As DOB says, they tend to make the music seem more 'open' in that I can hear each individual instrument, something that I find very difficult to do when sober, which gives a greater appreciation of the whole of the music


Then again, I get the best 'music separation' (for the want of a better name) with dissociatives, especially if there's a serotonogic psychedelic thrown in on top of it!
 
fastandbulbous... will shrooms + lsd + mdma + nitrous combo be very good at music detial and intensity??? this is best combo I think after reading all posts.

best thing to music listening is dob with weed... I will trow some lsd next time I get some dob.

high dose lsd with weed and piracetam is fun too,,, but that isnt like "I hear every instrument" but more like "I hear every hertz,not single vibration can escape my senses!" my consciousness travells to headphones and I become one with them... that explains extreme 100% hearing detail.Its like time slows down and my brain can process audio stimulation 20x faster and much more effective than normal... if I can compare it,weed alone can do this too but much weaker... like 1.5x faster.I live for moments like that.
 
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I'm currently... Reading about LSD saturation levels and would like to know more

...reading Psychedelic Encyclopedia by Peter Stafford.

In his book he states that the saturation point for LSD is around 500mikes, after which there isn't that much discernible difference in effects.

So where does that leave the case for high dose trips of 750mikes upwards?
 
I think the book is implying that regardless of whether you take 500 ug or a thumbprint, you'll experience the same effects as the "saturation point" is 500 micrograms?

I don't know the nomenclature but I guess what you refer to as "saturation point" is the level where no more effect is produced because you can definitely saturate more than 500 mikes on your tongue! I'd also speculate that al though the effects may be diminished with each individual interger in higher doses, each integer should have a corresponding higher level of intensity, probably past 500 mikes. Who that has done scientifically known doses of LSD can give some insight as to what dose of LSD is the maximum, as any higher doses will yield the same effects?

Or can you just keep pushing Lucy further down that rabbit hole?...
 
I've read that a thumbprint blows straight past the saturation point.

I've never taken more than probably 400ug at once [though it's impossible to be certain] general consensus among less educated trippers seems to elude to "10 hits isn't as strong as 15 hits"

In large doses of lsd in animals, the negative side effects seem to increase [though it's near impossible to measure anything other than positive/negative physical response] with the dose.

i'd be interested in seeing some scientific literature on this...OH WELL.
 
Love sex desire, yes it meant the saturation point as in what mental effects you can achieve, not how much crystal would saturate into your tongue or anything like that!!
 
I'm think he's talking about serotonin 5HT2A receptor saturation; LSD is very promiscuous with dopamine and histamine receptors as well. That's why subjective effects are altered when you take dosages exceeding 500 micrograms.
 
also, if you take 500mcg orally, you're not going to get all 500mcg past the blood brain barrier, or likely even into your bloodstream at all. Some will likely be destroyed by digestive processes, and i'm not sure what LSD's bioavailability is, but I know its less than 100%.
 
with almost every other class of drug, there is a ceiling where no matter the dose, there can be no more effects. however psychedelics, especially acid, are very unique. im guessing the limits can be pushed much much farther than that, but it would be impossible to tell.... i would just predict ego death past a certain point
 
20,0000 ug does tend towards cross receptor subtype saturtion. which is different than saturation at 10,000, or 1,200 or the balls out 400 mikes.
 
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