drinky_mcbeer said:i took 12 halves at the start, being my first time i didnt want to take too big a dose without exeriencing what was about to happen, half an hour later i took another half then half an hour later i took the panadiene fortes. next time should i jsut take 24 halves at once?
thanks evryone for quick replies
From Erowid:
*CYP2D6
The body converts codeine into morphine (~10% ) by using the so called P450 cytochrome pathway, especially cytochrome 2d6 (cyp2d6). Unfortunately, cyp2d6 is missing in about 7% of the white population, and its manifestation is quite variable in the rest. Individuals who inherited a cyp2d6 deficiency will get many of the adverse effects associated with codeine but little euphoria. If codeine just doesn't work for you, this may be why.
Some drugs also interfere with cyp2d6. Prime among these are the SSRIs, with the exception of Zoloft (if I remember correctly). The most potent inhibitor is paroxetine (paxil), followed by fluoxetine (prozac). If you are taking an SSRI, you will probably experience a markedly decreased euphoria when using codeine. (Paxil has a half life of only 24hrs, so not taking it for a few days will do miracles; the half life of prozac is 7 days.)
Finally, codeine itself is a cyp2d6 inhibitor. This means that taking the whole dose as quickly as possible will probably give you the biggest high (ie. its a waste to redose in 30 mins).
Perhaps you didn't feel anything because of the redose problem?

