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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

EADD: New (and less new) RCs - steric hindrance and vestigial rituals

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^^Serendipitously, I posted a list to that thread yesterday, on request. My point was that ticking drugs off the list is even less important or worthwhile than accumulating notches in a headboard.

Swarm, I'm not a pharmacologist at all, though I do appreciate your kind compliments. The human body is such an overwhelmingly complex system that I long ago decided to treat it as a "black box", and focus on what kind of chemicals go in and what kind of experiences come out, without worrying over exactly what happens in between. Of course, this is stultifying, and ignorant, but I find enough to concern myself with in electrons, feminism and cricket, without chucking bloody pharmacodynamics into the mix.
 
^That's true of any amphetamines, I think, I still don't know shit about pharmacology, but with any of these APBs, as well as more prosaic things like phet or MD, the more alkaline the stomach, the more bang for the buck.
 
This chem really loses its effectiveness with daily dosing. 100mg feels like 20mg. May use this on weekends once a fortnight/month. I'm quitting opiates so this may help the cravings.
100mg just feels like Super-caffeine with very mild psychedelia.
 
@ babylonboy - it's definitely all about the electron. One day I shall understand the schrodinger equation! (In reality I probably never will but one needs goals in life I believe.)

@ SproutOnSmack - yeah I'm not surprised that the 5eapb is losing its zing with use on consequetive days. I find that all those types of drugs feel like they have a "refractory period". I like to use that term as an analogy with a neuron's action potential because mdma, mephedrone, 6 apb all feel very similar in that way ie. past a certain dose you get this crazy cascade of effects, which you can draw out a little bit with redosing, but after that the shutters come down and your body just doesn't want to know for atleast 3 or 4 days. I always used to be the worst one for that when I first doing pills. I would flog a dead horse every weekend, for no real reason whatsoever. The first couple of pills are out of this world but 24 hours later when you're dropping number 11 and 12 you're just creating a sweaty pointless mess.

Incidently, the mechanism behind this is what also causes tramadol to be a bit of a non starter on a come down from phenethylamines / stims like this. I would have to look this stuff up again to be super confident but I think the 5 eapb type drugs cause the drop in effectiveness by regulating the cytochrome p450 enzymes in some way (basically stops them working for a couple of days) and since tramadol is a pro drug it needs this enzyme to set the active metabolites free. I'm not banging on about this to try and derail the thread so much as I thought a heads up on this might be usefull in your line of work. I don't know if you take tramadol, but I saved quite a bit of wasted tramadol after I figured this out. The number of times I would turn up to work on the worst pill comedown ever with nothing but a pocket full of tramadols to see me through, only to stop second guessing the lack of effects and switch to benzo's when I figured out what was going on.

What do you study? One of the bio-sciences? I really regret not having taken a more direct route to the sciences. I took the weirdest route ever into the sciences ie. social sciences and psychology at college, then psychology at uni where I discovered a passion for neuroscience half way through. I basically took all neuroscience modules but was seriously hindered by my lack of biology background and had to learn what I could on the fly. If I had my time again I would definitely have hit the bio science degree straight away I believe.
 
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ColtDan said:
Amazing aint it =D

Dunno how 4-aco-DMT compares to the N,N,DMT, sounds wicked though

My first trip... it was profound, unbelievable experience

http://www.bluelight.org/vb/threads/518914-First-DMT-Experience
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Bit late with the reply but that's a pretty epic report there mate. I foolishly wasted a good opportunity with DMT a couple years ago. Should have kept it for a proper occasion like that. Still have some Changa somewhere hidden but god know how much it may have degraded over the past couple of years (it's double, vacuum sealed packed). Although I know it's still different to the the lift off typical DMT experience. I couldn't possibly compare 4-AcO-DMT with DMT unfortunately. Through my mega exploring I did read that people say that the visuals are more DMT like on it though. I did feel the visuals during the come up were very different from past mushroom experiences.

Shambles said:
Benzos won't kill a trip - nothing short of antipsychotics will do that really - but they should ease any anxiety. Obviously it's better to not have to use anything if possible. Many actually find that simply have a benzo around so that you know you could use it if you really needed it means that you never do need it. Alcohol can affect trips in somewhat more unpredicatable ways - can ease anxiety or can also cause confusion or - frequently - something akin to what you experienced: just feeling like you wished you hadn't used alcohol. Psyches often don't seem to like booze. Very sensible of 'em I must say.

That aside, your trip sounds pretty amazing stuff. Few things are as life-affirming as a really good trip where you come back full of positivity and eager to hold on to the insights you may have gained. And all for just 10mg? Sounds like a bargain too to me =D

Great stuff - I hope you can make good use of it :)<3
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Thanks mate, it really was one special experience. That's 4 days gone now and it's helped me with making some decisions that I need to take for the future. Although, there is still much contemplation to be had. There was a lot of deep stuff going during it. I couldn't stop writing stuff down! I got struck down with the cold the next day unfortunately, but I was in a great mood. Was a very strange feeling :D

Very powerful stuff, I'm quite envious that people can take it recreationally. One of my friends told me about his experience taking it at a party and ended up buying some for himself after loving it. Also read reports of people taking it out and about. Would be amazing if I could handle that but this one is not for me for that type of stuff.

Seems to be a bit a debate in the past about degradation effecting trips, not in the best way either apparently. Stuff turning brown etc I will be doing this on the odd occasion and don't think I would be stretching out doses too much, considering that last time. I'm not really sure what to do with it, just chucked it in double bags hidden away so hopefully it doesn't affect my stuff too badly.
 
hopefully testing something out called Pyrophenerone which will be like Pyrovalerone (which is the PV part in MDPV). in the next few days cant say more than this about it at the moment and its a freebie so no loss if its no good but I hope it is as I need something new for my collection .

and yes I know one step forward one free sample backwards
 
Swarm said:
@ babylonboy - it's definitely all about the electron. One day I shall understand the schrodinger equation! (In reality I probably never will but one needs goals in life I believe.)

@ SproutOnSmack - yeah I'm not surprised that the 5eapb is losing its zing with use on consequetive days. I find that all those types of drugs feel like they have a "refractory period". I like to use that term as an analogy with a neuron's action potential because mdma, mephedrone, 6 apb all feel very similar in that way ie. past a certain dose you get this crazy cascade of effects, which you can draw out a little bit with redosing, but after that the shutters come down and your body just doesn't want to know for atleast 3 or 4 days. I always used to be the worst one for that when I first doing pills. I would flog a dead horse every weekend, for no real reason whatsoever. The first couple of pills are out of this world but 24 hours later when you're dropping number 11 and 12 you're just creating a sweaty pointless mess.

Incidently, the mechanism behind this is what also causes tramadol to be a bit of a non starter on a come down from phenethylamines / stims like this. I would have to look this stuff up again to be super confident but I think the 5 eapb type drugs cause the drop in effectiveness by regulating the cytochrome p450 enzymes in some way (basically stops them working for a couple of days) and since tramadol is a pro drug it needs this enzyme to set the active metabolites free. I'm not banging on about this to try and derail the thread so much as I thought a heads up on this might be usefull in your line of work. I don't know if you take tramadol, but I saved quite a bit of wasted tramadol after I figured this out. The number of times I would turn up to work on the worst pill comedown ever with nothing but a pocket full of tramadols to see me through, only to stop second guessing the lack of effects and switch to benzo's when I figured out what was going on.

What do you study? One of the bio-sciences? I really regret not having taken a more direct route to the sciences. I took the weirdest route ever into the sciences ie. social sciences and psychology at college, then psychology at uni where I discovered a passion for neuroscience half way through. I basically took all neuroscience modules but was seriously hindered by my lack of biology background and had to learn what I could on the fly. If I had my time again I would definitely have hit the bio science degree straight away I believe.
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You're right, my CYP2D6 enzymes are barely functioning. I didn't think about that before I took a decent dose of opiates, it's barely hit me so that was wasted, but thanks for the heads up for future reference!
I'm currently studying Micro and Molecular Biology BSc (Basically, a combined Microbiology and Genetics degree), but I do find BioPsych fascinating. I was originally going to take the Medicine route but every time I read an article I could guarantee I'd be far more interested in the pathogenic causes and the genetics behind it, as opposed to the physiology.
 
CYP2D6 that's the one I was searching for but unable to dredge up. I love genetics. That's the stuff I remember first learning on the fly, or trying to learn on the fly, when I did my first degree like 10 years ago. I was so poorly equiped to study the modules I was choosing its hilarious. I had no idea what charge was but I sort of had a grasp of the sodium and potassium ions etc. . Then I was up all night in the library trying to learn what transription and translation mean't - off wikipedia! I had plenty of gusto but that was about it. Some A level biology might have helped me out a bit too. Still, you gotta do these things I guess.
 
Anyone know what the recent quality of 6-APB is like? Tempted to give it a shot, as it's been absolute ages since the last time I tried it. I reckon I would be in a good place to compare it with 6-APDB, which was my favourite chem last year.
 
foolsgold: Do you think this is because the market and operators was primarily located in the uk, or just that it never caught on in other European countries?
 
4-FA is banned in the uk and its not shit. then again it aint coming from the uk

I used to love 6-APB, amazing stuff. started giving me headaches through and lasted a bit too long
 
Nah i'm sure if you imported from EU vendor it'd be fine, just the UK vendors that are still selling it it'l be shite. Cause they're blatantly selling something illegal.

If you meant EU vendors are shite, i disagree FG, its not like its made here, main labs are china, asia and europe
 
bob_arctor said:
foolsgold: Do you think this is because the market and operators was primarily located in the uk, or just that it never caught on in other European countries?
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yer most likely that :)

before a certain site got shut the was few post saying just this that it was not as good as it was before but i could say personally as i never liked it much
 
foolsgold said:
as its banned in the uk most likely shit now
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that argument definately applied to mephedrone. Im not sure how much it applies to other RCs. All the RCs ive got from europe have seemed fine, but i cant in all honesty say that ive compared them all to the UK pre ban product. Im talking about things like MDPV, Pentedrone, 3fa, 4fa etc. I never bought them whilst they were still uk legal, but the european versions seemed ok. Apparently the european MXE is fine too. I havent personally tried it as i dont get through very much MXE.
 
Mephedrone is illegal in China, so you can't get it anywhere. 4-MEC and MDPV are going as well. Most shit, though, the UK bans but few other countries do, so they still do the rounds. FWIW, all the fluoro-amphetamines have been class A since the 70s, long before they were ever sold as designer drugs.
 
4mec was allways shit, whether it was uk pre ban or european post ban. It just had so much to live up to, its hype promised so much, but the substance itself did little more than keep you awake at night. One of the most shit substances ever invented, i just cannot understand why it's so popular, or why so many vendors tried to sell it at least.

Your Chinese theory about the reason for the lack of proper mephedrone is very interesting. There was talk about Indian labs starting to make it a year or 2 ago, i dont know what became of that. Presumably very little as there hasnt been any 'shock waves' of excitement, non that have reached me at least.
 
'Cos it passes for meph on the black market, I reckon. Definitely not demanded in its own right.
 
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