Hey never posted on this forum before; I'm unfamiliar with the guidelines of it, so if this post is not relevant, I apologize.
But I have been extensively testing ULDN for about 3 months on different opiates and measuring the tolerance accumulation and subjective analgesia and euphoria of the experience with the goal of creating a sustainable level of positive mood with the goal of treating my long-term depression, which has only ever really been helped by opiates (at least in the period of time where the euphoria was the dominating characteristic of the experience).
In my research I found that with 7oh, the effectiveness of this is EXTREME, to the point where my tolerance to the analgesic effects will go back to baseline by simply skipping a couple doses with minor withdrawals. In fact, at multiple points as a result of being oriented towards more of the aspect of euphoria, I tried my hardest to take the highest tolerable dose every 1 hour, tolerance would build within the day but quickly diminish from that point even quicker.
I theorize this may be in part of beta arrestin recruitment with 7oh is low by itself, thus after finding my sweet spot with ULDN (8.5mcg), my body does not seem to retaliate with tolerance at all.
FOR REFERENCE, my higher end 7oh dose on average is about 5mg (which is what I started with when naive), and I can push myself to get to the point where I just barely tolerate 10mg. In the past without ULDN I could easily build up to 20mg within a week of daily moderate dosing.
My testing on other full agonist opiates such as DPP-26 and O-DSMT is not fully complete, but what I can gather is due to the nature of them, they seem to activate the body's tolerant mechanisms even under ULDN and as a result your baseline naive dose will still go up, slowly, but still will rise.
I absolutely hate the effect opiates have had on my life by showing me a way of existing that feels like every moment is worth it. Within the grips of euphoria, it feels as though I can finally do the things I have always wanted to do but have been hidden under a deep fog brought on by my anhedonia and naturally pessimistic mindset.
The biological mechanisms of the brain designed for survival in stressful situations has been overactivated as a result of my past and all my years of living have been a constant sludge of persisting under the immense challenges this brings. I just want to function and move on in life but I have tried LITERALLY everything, and consistently most things work for a little and then fail leaving a new deficit of pain to overcome. The brain naturally wants me to go back to my homeostasis, but it is not the place that I thrive in.
My major issue is, despite ULDN lowering my tolerance, the analgesic effects of opiates simply dulls my mood further and makes me content with doing nothing, but ONLY nothing. I know the tale of chasing that naive state where opiates are almost like stimulants in how they provide motivation is extremely naive and just another testament of a person chasing the dragon of the first time glory. SR-17 has shown the exact same formula of just restoring analgesic tolerance rather then the sought after euphoria.
I have been desperate, trying various NDMA agonists at various doses and frequencies, trying everything from studying and experimenting with the roles of androgens and estrogen on the opiate receptor and trying various cycles of them, to eliminating prolactin, to even trying an extremely experimental KOR blocker called Nor-BNI at 100mg to try and block the role of dynorphin.
Nothing has restored the consistent full range euphoria of the past; the MOR receptor seems to uncouple from dopamine expression regardless of the actual MOR receptor tolerance state. At least if I ever need pain treatment, I have a protocol that would work indefinitely. But at the same time I am very defeated in this venture. I am left with brief flashes of 5-10 minutes of the exact feeling I have been chasing each time I dose followed by a crash of disappointment and persisting analgesia. I still intend to chase some solution to this problem and learn more about the brain, as in the midst of this I have found great purpose and interest in pharmacology in general, but to a much less obsessive and risky degree, as soon I am starting my next semester of college.
I implore ANYONE with any insights on this subject to chime in or with any questions.
I thank you deeply
Hexenstahl for bringing attention to this fascinating mechanism of tolerance prevention and the wonderful insights you provide to others in this forum.
I wish you and all people who contributed this forum the best in life
) is 100% motivated by the desire to eliminate the diminishing rate of return that opioids have in regards to their full-spectrum effects when taken long-term. The only shortcoming of this beatiful substance class is that it doesn't work like weed. It doesn't matter if you have been smoking weed for 1 year, or 30 years. As long as you increase the dosage you'll still feel the same spectrum of effects you felt the first time toking that joint. Not so with opioids. If I wouldn't know it better I'd believe that it must be a sadistic curse the creator infused the poppy plant with.
