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ULDN - The magic weapon to reduce and keep tolerance to Opioids low

Hi, everyone. Sorry if this isn't the best place to post this, but after searching around the forums a bit, this seems to be the most extensive ULDN thread on Bluelight. I've been researching ULDN for a while now, but unfortunately it seems that there aren't many firsthand experience reports out there. So I thought I'd share mine here in case anyone else out there who is in a similar position might come across this and find it helpful.

For context, I'm an IV heroin addict who has been using on and off for years. At this point, I've reached a level of tolerance where I'm considering getting and staying sober because it doesn't really seem worth it for me to continue using unless I can find a way to make ULDN work for me. I'm just not getting the desired effects from the drug anymore, and the habit is becoming increasingly difficult to keep up with for rapidly diminishing returns.

I tried ULDN for the first time yesterday (6/2/2024) using a slightly modified version of the method described in the OP. The only differences were in some of the equipment I used: a 500mL water bottle instead of a 2L water bottle and a 1mL syringe instead of a dropper. So the math for me was as follows:
50mg naltrexone pill = 50,000μg nal total
50,000μg nal / 500mL water = 100μg per 1mL
1mL = 100 units on syringe
100μg nal / 100 units water = 1μg per unit
5 units nal solution = 5μg* nal
*I decided on 5μg naltrexone as my starting dose based on what I read in this thread and elsewhere online.

I dosed the naltrexone orally at 12:06pm. I didn't notice any withdrawal effects from the naltrexone. I waited just over 30 minutes before injecting 50mg heroin at 12:40pm. My usual dose is about 150mg, which at this point doesn't really do anything but keep me well. I didn't notice much from the 50mg dose, but I did feel better than I did prior as some mild inter-dose withdrawals were beginning to set in since it was my first dose of the day. It may have been a bit stronger than what I would have expected from only taking 1/3 of my regular dose, but it's hard to say for certain.

About 15 minutes later (approximately 45 minutes since dosing the naltrexone), I injected another 100mg heroin which felt equal in strength to, or maybe even a little stronger than, my typical 150mg dose. I suppose this may have simply been due to the cumulative effect of the 50mg + 100mg = 150mg combined doses, but it honestly felt as if I had injected the entire 150mg at once. I'm not sure if this was maybe because the 50mg dose simply wasn't enough for me to properly appreciate the tolerance reduction, or maybe the naltrexone took a little longer to kick in since I dosed it orally on a full stomach. Either way, I plan to experiment with increasing my naltrexone dose in the coming days to see what happens and hopefully figure out what my "sweet spot" for dosing is.

In conclusion, although the results of my first attempt at ULDN weren't as dramatic as I had hoped, it does seem promising. I'll post an update with any relevant findings after some more trial and error.
 
There was a woman who knew a lot about this and it so weird I was there when she got mad and left, as she said forever for having some post deleted. She started a thread and left for good, she was cool. You would have liked her. She was really into ULDN, it is a shame she left; you two would have had a lot to talk about. Hexenstahl, who started this thread. Be safe and good luck
 
Look though this thread, if you haven't all ready there is a lot of stuff about ULDN.
 
Dear all,

I am writing to ask for your advice in preparing a sterile Naltrexone solution for sublingual administration.

I am currently experimenting with a range of very low doses of Naltrexone. My goal here is not so much to find a Naltrexone dose that potentiates opioids, but a higher dose that begins to partially block some of the opioid effects and thus consequently reduces tolerance and eventually makes withdrawals upon opioid cessation substantially milder. This dose is the limit in which precipitated withdrawal should begin to occur. I have started trials at 50 micrograms and have slowly titrated to 200ug – I will post my results in due course after exploring higher dosages.

I decided to prepare a solution of 200ug of Naltrexone per millilitre. As I started from a 50mg tablet, this means that I ended with a total volume of 250ml, which should last close to a year. For it to last so long in the fridge, it needs to be a sterile solution – which unfortunately is not the case. In turn, to make a sterile solution for the next batch I was planning to bring distilled water to a boil and mix in equal proportions with 40% vodka (yielding a final solution of 20% ethanol). To this, the powdered 50mg Naltrexone tablet will be added, then the final volume will be filtered with a paper into various small individual containers (pre-sterilised with vodka). This process will all be performed under the sterile halo of a lit Bunsen burner.

What are your thoughts on this? Would the 20% ethanol be enough to keep the solution sterile, and would it interact in any way with the Naltrexone? How do you personally proceed when preparing your own sterile solution?

Many thanks in advance!
 
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Indeed, even for alcohol cravings 50mg seems like an overkill. How did you feel during the first days until your body got used to the Naltrexone?

My first trial with the substance was with 5mg and it made me grumpy, the next day I went ahead with 10mg and I felt intense anhedonia accompanied by a very deep and profound sadness. I promised myself I would never go again over just a couple of milligrams.
 

@Hexenstahl Just wondering if you can provide an update. Dose naltrexone still work for you? Have you considered using salvia as well or instead? Salvia binds to kappa-opioid like naltraxone, which may induce the upregulation of mu-opioid receptors.​

 
I decided to find out if ULDN had been tried as a way to reduce tolerance. I began to compile a list of papers and patents but I soon reached 200 and realized that few people would be interested in such a huge amount of reading. So I've settled on this single article as it's a decent index-patent (it references a lot of those other articles).

 
Finally I got my hand on some naltrexone tablets!
Wasnt super scientific about it just dissolved a 50mg in 500ml water. So 1mg is 10ml i think. So im gonna have just one drop in the morning followed by my usual 75mg methadone which i barely feel usually ,but this time around should be stronger!? Im so excited, will let you know how it goes
 
Me and a friend played around with it for some weeks.

At 10-100 micrograms.

It didn't work for us.
Neither in potentiating opioids (we tried it with O-desmethyltramadol & kratom) nor in stopping withdrawal symptoms not with lowering tolerance.

I'm skeptical.
 
Ok so I took 3 or 4 drops of my solution at 6am. Im guessing thats about 200-300 mcg. Was worried about precip. withdrawal but fortunately that didnt happen. at 9.30 i took my usual 75mg methadone. Now its 11.30 am and im not sure if the naltrexone did anything. I feel a light buzz like usual. Not sure if tomorrow should i take a bit more, or less naltrexone. I think im gonna try a bit more. And if it diminish the effects of methadone than it means its working and receptors are upregulating then the next day take zero naltrexone so then the methadone should kick in extra hard.
 
Ok so I did it again today, little bit less naltrexone this morning at around 7.30 and then went to the pharmacy soon as they open at 9. Same dose again obviously 75mg methadone.(Empty stomach as always followed by a small redbull) At around 10am it has already kicked in and i was feeling that proper opiate feeling i dont normally get from methadone. It was subtle and it wasnt like the methadone was stronger than usual but like i had more sensivity to it. (Like the sedatio wasnt stronger than usual but there was an opiate buzz usually isnt there) Then at around 11.30 smoked two small cones. That has really brought on the nods and the cinnamon pancakes i had for munchies. Was passin out betweens scrolling videos all day. Takin it easy today. Definitely not regretting trying this naltrexone method really got something to it. Will play around more with it
 
Today imso pissed off because got diminished effects. Even tho i do the same thing every day. Few drops of naltrexone followed by 75mg methadone. But i think i know why . Because i was taking naltrexone every day and so now it has built up to a level where it is not potentiating but blocking. Tomorrow will not be taking any naltrexone. Need to dilute it more. And do it every 2nd day not everyday. Im soo happy when it works but its a real bummer when I get the opposite of what I was going for.😳😭
Hope someone is going to learn from my mistakes at least. Gotta be careful with the dosage.
 
Still at it... Keeping it to 5-10 ug every morning works reliably well. For 8 days in a row now. Think i was doing a little too much in my earlier posts
 
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