Has anyone ever had some luck with combining Amphetamines and opioids? Can this combination be in any way rewarding? I suppose something like methadone plus mdma makes rather braindead…
For me, they're 2 great tastes that taste better separately. I've enjoyed opiated energy in the past, but after many years of addiction, a strong link has been built in my mind between the enjoyment of the opiate high and the feeling of sedation (pleasant sedation, that is, not the comatose sandbag state. So even caffeine can end up detracting from my opiate experience.
Even so, I don't love the effect of benzos on top of opiates, either. Gabapentinoids completely overpower the pleasant aspects of opiates for me and leave me scarily fucked-up. DXM can also be overpowering mentally. Carisoprodol, I combined with tramadol. Although I can't remember much, I think I enjoyed it. (I want to try it with bupe again, too— the Soma[dril]+Sub{utox} cocktail.)
The plain old opiate high doesn't really lack for much, IMHO. Mainly, I enjoy combining opiates with nicotine (obviously) and with antihistamines/anticholinergics — mainly while feeling stimmed or needing sleep. Although clonidine & tizanidine also combine fairly well (& increase the nod, for sure) I wouldn't see them as "improving" on a pristine opiate high under normal circumstances.
Amphetamine comedowns, on the other hand, make for a great combination together with strong opiates. Unless the dose is huge, it frequently gives me a "second wind," reviving the amped-up euphoria. Which feels good, of course, but sometimes comes too late in the game; that's where clonidine/tizanidine & AHs/ACs come into play.
Oh, wait— I remember one drug that was definitely rewarding combined with from: nitrous oxide with strong opiates. I liked nitrous in combination with almost everything else, but it did add a really nice "depth" to the opiate high; a tiny puff of marijuana from a one-hitter went well, too, enhancing the effect of the nitrous. . .