Currently nodding rather heavily. Did some reading during another sleepless night and found a dearth of information about potentiating Fentanyl, aside from the sarcastic "what kind of Junkie needs to potentiate Fentanyl?". Given Fent, like so many other drugs, is metabolised hepatically through the Cytochrome-P enzymatic pathway, primarily via CYP3A4, I decided to dose 200mg of Ranitinidine HCl 45 minutes prior to indulging in my opioid love. It certainly worked!
It's common knowledge that Fentanyl's effects last about as long as a teenager losing his virginity, however, by slowing its metabolism; doses administered sublingually or bucally are lasting noticeably longer than the 3-4hr maximum I've become accustomed to. Vaping another dose from foil whilst plateauing from the earlier dose provided the "rush" of instant gratification, the epitome of Fentanyl abuse, with added intensity and even prolonged it by a few minutes.
Needless to say; this does also increase the ubiquitous and unavoidable danger that comes with abuse of a microgram active opioid with significant respiratory depression relative to euphoria. As if Fentanyl could be any more dangerous...
N.B. - the 2mg of Nifoxipam, administered sublingually, was potentiated alongside the Fent - please be incredibly careful when mixing CNS depressants, particularly Opioids and Benzos/Alcohol.
Stay safe, guys,
A rather blissful Sprout.
