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The Big & Dandy Nootropics Thread

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I agree, 5HTP is useless (well almost, I'll give it to people who use MDxx around me just in case it might help them)-

jamshyd, have you ever used vasopressin - it is one I am interested in-

does piracetam also make you depressed if used several days in a row q mark-
 
hey mobblunted, you should put the powder in a bit of liquid and swig it down like you swig down liquor (ie you shouldn't really taste it)-

I find dosing piracetam once a day sufficient - it keeps me going all day-

you can try an 'attack dose' (google it) for piracetam on the order of 3-5grams at once - this might help you notice the effects so day two you can take 1-2 grams and have the same effect (nootropics you have to 'cultivate' the effects)-

peace
 
Alhough my kidneys are relatively healthy, they have always been particularly the most sensitive part whenever my body feels abused. As such, any change in kidney function scares the piss out of me ;). Since vasopressin is directly related to the urinary system, I'd stay the hell away from it!

I have not tried Piracetam, although I found Nefiracetam to have the same effect so I figured it is something that all 'racetams have in common...

The only nootropic I am still interested in trying is Hydergine - if for no reason then because it is composed of ergolines.
 
You should try piracetam. I have not tried nefiracetam, but I have tried oxiracetam and aniracetam and I find them to be NOTHING like piracetam- they are much more scrambled and chaotic than piracetam-

ergoloid mesylates (hydergine) is a pretty good nootropic, but it dilated my eyes like CRAZY, so I had to stop using it (because it would have become socially awkward to be on it while I was teaching and talking with people at school)-
 
I concur with the smiling samadhi, regarding the -acetams. Piracetam is the best of them (well, of the ones I've tried - pir, anir, and oxir). I have heard that pramiracetam is worth exploring as well but I've never been able to find it. I have found that a regular dose of piracetam plus a very small (100-200mg) dose of oxiracetam is better than just piracetam alone, but oxiracetam alone is not as good as piracetam. I simply don't like aniracetam... it gave me a funny feeling behind my eyes and seemingly no cognitive enhancement. Plus it's entirely unsoluble in water and is really messy. :X

Hydergine is a wonderful nootropic and tonic for the brain (and your cell's mitochondria). I don't have quite the same reaction to it as S_S, in that it does not dilate my pupils, but it is most definitely a valuable substance to me. Whenever I start to feeling in a funk, I take a dose of hydergine and piracetam in the morning and it bumps mke right out of there. I don't take nootropics every day anymore because after doing so for almost a year straight I felt that it wasn't really helping anymore, and in fact was making me feel a bit robotic or something. Taking a break until you need them sure brings back the effectiveness though.

I also love phenibut... tolerance builds rapidly so it should be a thing saved for days when you need a lift, but it sure can produce a beautiful and natural-feeling euphoria when saved for those instances.
 
Splatt said:
So you think 800mg-1g once daily will be enough from now on? :)
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Yep. Sorry, must have missed your post when it happened. I take 800-1000mg of piracetam when I take it, and it works as well as any other dose. In fact the large doses can be a little less effective because they actually alter you a bit more.

I also want to just generally add that nootropics aren't like other drugs in the effects that they produce. You can't just take them and in 30 minutes expect to feel a buzz. If you're just taking them and lounging about all day, you may not notice anything. Their effects become apparent when the mind is exercised. Then you'll suddenly find that everything is easier and more together in your head. If you can learn how to harness this potential, they can really be powerful (but subtle) doors into increased mental productivity and inspiration.

Also, I think people tend to go on the high side with piracetam dosages. For what it's worth.
 
I agree with the observation that people tend to overdose on piracetam-

for me 500mg-1,500mg is sufficient for cognitive stimulation in conjunction with about 250mg of DMAE (DMAE dilates my eyes somewhat around T+2-3 hours)
 
My stack (interesting term, I have not heard that before):

600mg Adrafinil
1600mg Piracetam
4.5mL Hydergine (sublingual, 1mg/mL tincture, 3x1.5mL per day)
500mg Citicoline
600mg Milk Thistle (to counteract possible liver effects of Adrafinil)
Multivitamin
Daily cardio exercise, and weights every other day
Daily meditation

IMO the last two are by far the most important. Eat right, exercise, and meditate. You will be amazed at the difference this makes in your attitude toward life.

I drink a ton of green and black tea as well. Sometimes I take another 300mg Adrafinil in the afternoon. Occasionally I take a combined SAM-e and 5-HTP product for mood.

One poster asked about Adrafinil: it has worked wonders for me. Like most of these drugs, it seems to have highly idiosyncratic properties. For me it produces a feeling of energized confidence and quick, clear thinking that lasts for at least 6 hours, with none of the "wired" feeling of conventional stimulants. I find "eugeroic" a perfectly descriptive term for this compound. I just hope it doesn't get scheduled the way Modafinil is (go figure -- A is a prodrug of M, so it's essentially the same freakin' thing; I guess the DEA needs some nootropics).

I get very mild effects from piracetam by itself, even in high doses. Piracetam plus hydergine is much more noticeable.

Let's hear it for BLTC, y'all!
 
On interactions with psychedelics: I don't stop taking any of the above when I trip, and I have never noticed any interaction (positive or negative) from any smart drug or supplement. Adrafinil seems to make my head clearer whether I'm on psychs or not, but it is an especially noticeable effect on tryptamines -- I don't know if that's an "interaction" per se.

As far as long term health risks -- all this stuff is completely uncharted territory, and if we wait around for clinical studies we'll all be dead. Nobody is applying for research grants on the interactions between piracetam and 2C-E. Like another poster mentioned, I tend to go with my gut. I feel if one is not willing to take that kind of risk, it is foolish to take any of these substances, together or separately.

Oh, speaking of 2C's, 2C-D is a very definite nootropic for me at small (10-15mg) doses. I have even, once or twice, gotten that rare and amazing feeling of knowing exactly what to do or say in any given situation, as though all the gears are turning without impedance and one's gestalt "true self" can manifest clearly. However, 2C-D builds tolerance quickly, and I am uneasy about taking it on a daily or even weekly basis. It's a very strong drug and not to be underestimated.
 
Yes, I wouldn't imagine taking 2CD everyday would be healthy for your HT2a,c receptors-

There is anecedotal evidence of a person taking low doses of 2CT7 everday for a year (I think) and tolerance not building much - apparently it builds much slower and sub-psychedelic doses-

Same for AMT at subempathogenic doses (apparently low like 5mg doses do not release much serotonin)-

I would NOT recommend anybody take HT psychs for their nootropic effects-

I also concur with exercise, lifting weights pumps me up so much, I actually get antsy on the days I have to rest from the day before :)
 
I agree with Xorkoth that nootropics are nothing like recreational drugs. They don't produce a "buzz" (well hydergine in too large doses does but in a for me unpleasant manner with a #*&$ body load).

Piracetam gives me a (temporary) cognitive boost, hydergine feels like it heals/clean my brain, more or less permanently.
Skipping piracetam for a day is noticeable, skipping hydergine for a day (I'm at 2.25mg now) is not.

Dunno if hydergine is a good idea for young people but it seems beneficial for the not-so-young.

A pre-night out dose of piracetam greatly reduces alcohol-induced stupidity, stupor and hangovers, at least for me it does.
I've read several reports of people claiming it just gets them drunk a lot quicker so mileages obviously vary.

So far I'm very pleased with the effects of my simple piracetam/choline bitatrate/hydergine stack and will definitely continue this experiment for a while.
 
caution, combining alcohol and piracetam may exacerbate toxicity issues with alcohol - this seems to be linked to increased absorption of alcohol across the BBB-
 
don't worry, I'm not much of a drinker and usually stop enjoying it after #6
 
delta_9 said:
1ug doses of lsd can be found I'm sure
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Of course. Just cut a known low-dose blotter into a 100 pieces or so. =D
Hydergine is relatively cheap and contrary to LSD dose-wise trustworthy I think.
IMO (I've done LSD) it feels quite different, and there's no reason to assume the effects are the same on a physical level.
And there IMO is where hydergine works.
 
No problem. I have several blotters that can easily be cut into a 10x10 grid.
 
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