I'm not sure how people can do this one at night? If I do MXE any later than 6pm I'm pretty much ensuring myself that I'll be up until 2-3am. Perhaps I am just more sensitive to the stimulant action but this is pretty consistent for me even after consecutive dosing over a few days where a mild tolerance builds and the main psychoactive effect diminishes.
I've noticed that MXE is best used, as is the case for ketamine (for me), via I.M. Any other route just produces an inferior effect. This was the case for ketamine, after repeated use through every other route, I found that I.M. was the only way to truly appreciate the substance.
One word of caution I'd like to pass along is that sometimes during an M-Hole dose (80-100mg) I'll become slightly amnesiac for a short period of time, yet be relatively functional. I can walk, I can do things, and that can get you in trouble. This happened to my girlfriend who was administered a M-Hole dose and then was capable of walking (with my aid) to our bathroom, brushing her teeth, getting in bed and holding a very limited conversation for an hour before she came back fully.
I once prepared a syringe for the next day filled with 4-AcO-DMT. After coming home from work I decided to utilize this syringe, fully forgetting what compound was in it. Assuming this was methoxetamine, I injected the full amount and was blasted into the most unpleasant tryptamine induced dysphoria I've had to date. It wasn't a terrible trip, but due to not being prepared it was entirely a wasted experience... UNTIL I combined it with a shot of MXE.
I can't wait to try this combo again, 4-AcO-DMT and MXE in a shot together should produce the same state I've reached on ketamine (true K-hole in my subjective experience), with 2-3x the duration.
edit:
Plugging Instructions:
To plug any drug that is water soluble you'll need a needless syringe, a pipette or
plastic eye droppers. dissolve the substance in as little water as needed, using heat if necessary. Suck up into containing unit and grab a lubricant, water based is preferred. Apply lubricant to the containing unit and your rectum. You can either be laying down on your back or on all fours with your buttocks in the air. Next insert the containing unit about 2-3 inches in (full length of most eye droppers I've seen) and squeeze the substance out in one single action. Keep the bulb squeezed while removing, in the case of an eye dropper or pipette. Otherwise remove empty unit and inspect for remaining contents. Stay in whatever position you are in for about 5-10 minutes to allow for full absorption then you should be good to go.