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The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

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I've done K and DXM a handful of times each, both at pretty considerable doses. That is the extent of my dissociative experience. However, I've done many psychedelics and gone swimming before, including a trip of 8g Ecuadorian Cubensis and 200mg of MDA. That was easily one of the best trips I've ever had and I was in the water for literally like 7 hours.

I'm not going to be doing any olympian swimming races or anything, I just wanna wade around and ride my giant turtle floaty. I'm going to go with t0aster's recommendation and start with 15mg and wait a while before I do another 15mg.

Thanks for caring ColtDan.
 
Anyone here familiar with something called SAM-e? Also called S-Adenosyl methionine. It is available over-the-counter in the US. It can be good for a number of things like a mood lift. However, I'm wondering if it might not be good to combine with MXE because I just read on the wiki entry that it can cause serotonin syndrome combined with dextromethorphan. From the data I am looking at it seems that MXE's serotonin binding affinity is less than DXM, but could it still be enough to risk serotonin syndrome?
 
vortech said:
Anyone here familiar with something called SAM-e? Also called S-Adenosyl methionine. It is available over-the-counter in the US. It can be good for a number of things like a mood lift. However, I'm wondering if it might not be good to combine with MXE because I just read on the wiki entry that it can cause serotonin syndrome combined with dextromethorphan. From the data I am looking at it seems that MXE's serotonin binding affinity is less than DXM, but could it still be enough to risk serotonin syndrome?
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It's allways risky to combine two not known enough drugs. There is no data about this. Probably it wouldn't cause a harm but for sure it is no 100% safe.
 
The results are in. I combined 200mg of this SAM-e with 100mg of MXE spread throughout the day starting slowly by late afternoon. The light doses by early evening were good. Not too much. A few hours later, after larger/stacked doses of MXE it became too much, possibly flirting with serotonin syndrome. It was like stacking happy on top of happy I was a manic tuney loon. If I had stuck with lower doses I would have been to able keep working on my AV project, but after 50mg of MXE, excitement towards everything rendered my attention span more useless than usual. It had been almost a week since I had dosed, so my tolerance to MXE was mild to moderate.

In conclusion, the SAME-e definitely ramped up the mania potential of the MXE. In low doses there didn't seem to be any negative interactions, but it did change the character of the MXE. It was pretty functional with a higher antidepressant effect. Higher doses became almost uncomfortably stimulated, so I'm guessing there was a little bit of serotonin overload.
 
I just added a small dose of mxe to my workout session and am surprised by the results. I turned up the old Afterlife Lounge Playlist and went into a trance like state of rows, curls, benchs, and crunchs.
 
Oh ROXIanne! said:
I just added a small dose of mxe to my workout session and am surprised by the results. I turned up the old Afterlife Lounge Playlist and went into a trance like state of rows, curls, benchs, and crunchs.
Click to expand...

I love working out on MXE, I can lift more and run FOR DAYS, I end up running around 5 times farther on mxe than not, Its really the best drug, all things considered and the best for you mentally in every respect that I've ever done.
 
Okay, time to post again. Having been through 1gr of MXE in 1 month 1 year ago, some 500mg in about 2week some months ago and now 3gr of MXE in one month, I can say this drug is really addictive.

But it's not addictive in the traditional sense where withdrawls get you. The seemingless benign effects keeps you coming back. My tolerance has risen tremendously though, but it's an interesting yet odd tolerance. 100mg plugged didn't do much, 50mg sublingual didn't do much either, but 50mg nasal always got me the effects. So I have been dosing 50mg (starting dose, dosing multiple times through the night) everyday for 1 month now, and finally my supply has run out.

The drug has many ups, but also downs. It can get so fucking confusing at times, to a point where you feel like you got brain damage. You mumble and you become an incoherent mess. You can't walk straight and you look like a zombie on it.

But it's euphoria, it's instant mood boost (I call it the "Mood resetter drug" kept me going back, because I was feeling really happy from it. It put you in an interesting state and lasts quite a while and also allows for easy sleep. It's really fun to lay in bed on this stuff, as you feel like you're sinking and flowing.

Well that's that. I'm taking a break. Tolerance got too much of an issue and it was also very addictive. Great drug, but you have to sleep the effects off, or else you feel zombified the whole day.

Also, whenever I was on MXE and I took a drag from a cigarette, the rush hit me straight in the face tenfold. It made everything ring as if I had tinitus and my body vibrate. Neutral effects..
 
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Thanks for sharing WhiteDream. I've found the same sort of compulsion you referred to with both MXE and ketamine. It's not the type of draw that dopaminergic drugs have where you will do anything to get the next dose, but more along the lines of if it's available to you, you'll find yourself doing some. I've found the best way to counter this type of compulsion is to buy it in small quantities and space out your purchases by however long you determine to be necessary. This lets you still enjoy the drug from time to time without falling in to a cycle of use that comes about from having excessive amounts available all the time.
 
I've come to the conclusion that MXE its a must to close your eyes to really get the trip going. I wasted most of the trip yesterday when I was just browsing the web etc at my pc eyes open, but as soon as I went to bed (and this was ~3hrs after last dose) it really showed me the magic. How do I always forget it? MXE eyes closed is the thing IMO and that's when MXE shows its true potential. The euphoria is magnificent.. Wow. Being up and doing something is mostly a waste for me at least..
 
the eyes closed experience definitely has a lot more character than open eyed. I love laying down to go to bed after doing mxe that day and thinking through a bunch of stuff in the lazy river of my mind.
 
I never really got much from the closed-eye MXE experience, especially in comparison to ketamine, but I also never pushed the dose very high because I was satisfied with the effects I did achieve. I just found with ketamine I was able to become fully immersed in the dissociated states, and the closed-eye visuals were very immediate and realistic, while with MXE I would get some of the bodily effects of ketamine like floating around in endless darkness, however I could never become immersed in the visuals, they always seemed slightly distant and difficult to perceptively grasp.

I'm debating getting more MXE some time in the future to push the dose above what I have previously tried. 25-45 mg I found to be my comfort zone, depending on the situation. With more I found I became increasingly confused and cognitively dull, but I do want to explore it again to determine if it holds the same merits as ketamine.
 
^If you enjoy cannabis, you should really try some with MXE and then go close-eyed

There's not too much visuals when doing low-medium doses, but doing higher doses its a different story.

Really, when someone tells me he doesnt like MXE or something I'm certain he hasnt done it properly (right set & settings, laying on bed closed eyes with music etc)

It took me 5 to 10 times until i really started to enjoy (love) MXE. before that it was just weird.
 
Exactly the same here, wasnt overly keen on it quite a few times... until i treated it with respect and dosed it properly... and kept hydrated throughout. and didnt mix it with stuff. then it turned into an amazing euphoric magical beauty. weird as fuck but comfortably weird. and glowing days after. and MXE should be very much closed eyed amazing-ness if done right
 
I did use cannabis with MXE back when I had some, and did find it added to the experience however I still never attained the lucid or vivid visuals that I have with ketamine. I also used it in darkness while laying in bed with some music playing (Shpongle always synchronized well with my ketamine experiences). I suppose I would say that the closed-eye visuals on MXE were similar to thinking about an image (for example, a boat) while with ketamine the closed-eye visuals were akin to physically perceiving the boat as I would in real-life.

I'm guessing it's fair to assume I never pushed the dose high enough which is kind of sad. I always came out of ketamine experiences wishing they had lasted longer but was never up for redosing afterwards. It sounds like with MXE I wouldn't need to.
 
SAMe has been added to the OP in the MXE combinations subthread (though not sure if it only belongs in the 'suspected' or dose-dependent section). Everyone considering to combine MXE with something else remember to refer to that thread and please contribute if you have information that is additional to or different from what we collected so far.
As I mentioned there, MXE is an SRI so the concern is valid and vortech reaction makes sense.
 
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