I jut bought some DOM tabs and am wondering if the psychedelic PEA's deplete serotonin the way MDMA and methamphetamine do?
I just want to be careful with anything that creates a "hole" that needs filling later...hence the depression following some PEA's.
If not, then I may try using it on a semi-regular basis a little like Xorkoth does with DOC.
The DOM I have are 2.5mg blotters so dosing will be much easier than with DOC I think.
Sol? Xor? anybody?
They're known to have significant affinity for serotonin transporters, and though most studies only quantify them in terms of IC50 (thus measuring only reuptake inhibition), they're also known to be TAAR1 agonists and so likely act as serotonin releasers to some extent--though I suspect their high lipophilicity trends them more towards blocking over releasing--similarly to mephedrone) This being said, the active dosage here is extremely relevant: Even though DOx compounds are probably at least as strong if not stronger as serotonin reuptake inhibitor/releasers than their relatives (parachloroamphetamine, paramethylamphetamine, parabromoamphetamine) they're dosed at an order of magnitude below the psychoactive dose of those compounds.
There's also evidence of 5ht2a-receptor-associated neurotoxicity in animal studies with DOI.
I don't know how you define semi-regular, but I don't think Xorkoth uses it all that often. He used to use it frequently when he was abusing psychedelics.
Although I've taken a break from tripping, I was probably the second most prolific user of DOC on this forum, after him, though I tended to use it in lower doses. I would even occasionally redose it at sub-milligram quantities for many days at a time--just using it as a stimulant.
I'm going to go ahead and say that that sort of behavior is extremely unhealthy: sleep disturbance, bio-accumulation, chronic 5ht2b agonism, etc. And subjectively, DOC certainly feels hard on the body. But at the same time there's no compelling evidence in favor of enforcing mandatory 3 month waiting periods between trips, or anything like that.
I will say this: as Shulgin said, DOX are dyed-in-the-wool psychedelics. They're deep, they're visual, they're long, they're physical, and they're harrowing. if you abuse them, you
notice.
On the other hand, I've found that DOC is sufficiently powerful that you can trip on it the day after tripping on another psychedelic, with almost no change in intensity of effect. You can even trip two day consecutively, with "relatively" little dosage escalation. Not that I'm recommending that behavior, of course.
