arrall
Bluelight Crew
It probably has poor oral absorption like most dissos. Maybe you got a bad batch? I'd try insufflating 30 or 40mg.
Dissociatives The Big & Dandy DMXE (3-me-2′-oxo-PCE, deoxymethoxetamine) Thread
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Xorkoth
Bluelight Crew
I wouldn't say most dissos have poor oral absorption, some of them do, though. Seems like MXiPr, MXPr, and DMXE all work better nasally (as well as ketamine). However a lot of others, including MXE, 3-MeO/HO/PCP/PCE, DCK, and 2f-DCK, all are stronger orally than nasally for me.
On mxe I was tripping balls/holing on 80mg, dmxe to have some sort of trip was 120mg minimum with me ymmv
arrall
Bluelight Crew
I haven't done any of those in the latter category, but from what I have read a lot of people seem to find those to work slightly better nasally. Effects obviously differ from person to person.
Regardless, you are definitely correct in that all of those are far more effective orally than something like ketamine or DMXE.
Mjäll
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Low-medium tolerance, medium experience
I did 10 mg bumps, maybe 5 total over many hours. Surprisingly strong and lasting. Very user friendly, very nice. I think it's close to MXE, on par with MXE and ketamine. No toxic feelings. Plenty of healing. Easy on the nose.
I don't aim for holes (unless nitrous is involved) but a single dose of 70mg MXE once had me holing and i think a single dose of 70mg DMXE could achieve similar confusion.
I am amazed that such bliss exists and equally amazed by my own temperance with it.
I did 10 mg bumps, maybe 5 total over many hours. Surprisingly strong and lasting. Very user friendly, very nice. I think it's close to MXE, on par with MXE and ketamine. No toxic feelings. Plenty of healing. Easy on the nose.
I don't aim for holes (unless nitrous is involved) but a single dose of 70mg MXE once had me holing and i think a single dose of 70mg DMXE could achieve similar confusion.
I am amazed that such bliss exists and equally amazed by my own temperance with it.
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For those of you that don't use any sleep aids, what's the afterglow like? In the beginning i had amazingly good, if not hypomanic afterglows that lasted for at least 3 days, probably rivaling the high itself considering it was so good and natural. that was before i started taking sleep-aids on regular basis and i don't get the same benefits.
Mjäll
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They study ketamine for depression for good reason. Something about the dissociative state results in antidepressant afterglows, similar to psychedelics. I think this effect is inseparable from the acute "happy chaos" of mind and thought which we primarily seek. First we desire and give ourselves an artificially augmented ability to think and feel, then we think and feel a lot, and then we enjoy the results. Good instinct.
For me DMXE had a therapeutic headspace and a corresponding afterglow. Very comparable to previous sessions with ket or MXE (or PCP analogs) in all respects.
I would not describe the afterglow as hypomanic. Maybe it could be hypomanic for some people in some circumstances. For me hypomania is integrated in cynicism as a permanent character trait. It is a force to be controlled. I would not appreciate it as a residual drug effect. What i like about dissociative afterglow is harmony and self affirmation.
stardust10
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Anyone here noticed a heaviness when trying to breath when taking it? It happened after smoking a pipe of green a few times - I might have been being paranoid, I think I am tbh, will see better when I take it again tomorrow. But has anyone else experienced any heaviness in their chest at all? I get it sometimes when I smoke anyway but not as bad so could be anxiety related or something.
arrall
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No, but this could be respiratory depression which isn't unheard of with dissociatives such as DXM and ketamine.
stardust10
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Thanks. Do you know if it's dangerous/should I be worried about taking it again?
arrall
Bluelight Crew
I don't think so, unless it becomes difficult to breathe without smoking the weed.
Mjäll
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Generally these substances don't kill even at anaesthetic doses which are quite a bit higher than recreational. With a novel RC, we can't be too sure and cocky of course.
Maybe try a lower dose? I found a lower dose to be very introspective and immersive and my lungs felt better than normal.
Most likely the DMXE facilitated an unusual response to the sensation of smoking, which of course isn't good for the lungs.
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It could also be randomly placebo. I have tried several substances in the past, none of which should have any kind of respiratory depression, and normally they didn't, but on rare ocassions it happens you focus on the wrong thing and it brings out somekind of placebo effect. I notice this more with heart / cardiovascular changes as i worry about that more. Also DMXE might not be a holey-disso but i'd classify dissos as psychedelics and they can have weird effect on your psyche.
stardust10
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Wondering if it might in fact be heart/BP related as had high BP before and had a resting BPM of 180 and had to go to hospital a couple times (when I was drinking heavily). Want to bomb 100mg tonight, last time I started with 30 and worked my way up. It really helped my depression and anxiety there and really can't wait to take some more but can't help but feel a bit apprehensive.
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Mom's Spaghetti
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You shouldn't mix dissociative drugs with alcohol it's an unsafe combo.
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Recently got a small amount of dmxe. First day I had it I dosed 30mg IN 3x for a total of 90mg. It was like my lingering malaise and depression completely vanished, and I was finally able to be myself, crack jokes and have fun again. Dosed 30mg IN X2 for a total of 60mg yesterday. I felt like I actually had more effects from it yesterday, but I'm currently riding the afterglow and still feel very good while having not dosed anything today.
This is my third trial with a small amount of dmxe, and I can honestly say I love it. Straight up. One of my favorite dissos, if not 2nd best behind MXE. It has a much smoother quality to it, which is enjoyable in it's own right, while having a bit longer duration than ketamine.
I've resigned myself to the fact that my love affair with dissociatives probably won't go away. I just want to try to stick to the mxe/ket analogs from now on, as they do seem to help me therapeutically, when used responsibly.
This is my third trial with a small amount of dmxe, and I can honestly say I love it. Straight up. One of my favorite dissos, if not 2nd best behind MXE. It has a much smoother quality to it, which is enjoyable in it's own right, while having a bit longer duration than ketamine.
I've resigned myself to the fact that my love affair with dissociatives probably won't go away. I just want to try to stick to the mxe/ket analogs from now on, as they do seem to help me therapeutically, when used responsibly.
Xorkoth
Bluelight Crew
Awesome man. 
Yeah, DMXE is good stuff, for sure. I think of it as the closest thing to MXE
Yeah, DMXE is good stuff, for sure. I think of it as the closest thing to MXE
simstim
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I'm glad to hear that it sounds worthwhile. Definitely interested in trying it.Awesome man.
I'd really like to try 2-BRDCK but kinda on the fence. 2-MEODCK was great but I required almost twice the dosage compared to ketamine for similar effects.
Why aren't there more experience reports about methoxmetamine? Was it a dud?
Xorkoth
Bluelight Crew
I have no idea. There are actually a few people who said it was amazing, but the dose was high. I think the dose was just too high and a lot of people were used to MXE and called it a dud. I never got to try it, myself.