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Dissociatives The Big & Dandy DMXE (3-me-2′-oxo-PCE, deoxymethoxetamine) Thread

jhjhsdi said:
Sounds alright in the sense you arent going to hole 3/4 of the way down the barrel and come round with a 1/4 full rig on the floor, BUT what is the initial rush like? There? Not there as in like IM k?

You could try the green tea thing but id personally recommend a few pints of quality apple juice or even better a strong scrumpy cider, works wonders
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I assume you mean DMXE when asking about the rush. I love to IV ket or dck, both has a great rush, but they are more cold and sedative compared to MXE if memory serves me right. DMXE has no rush when Iv'd compared to other dissos I've tried. Though administration is done in a Vein (IV'd) it still takes a long time (2-3min or so) for effects to build up on your body and your mind. I don't dislik this chemical att all, But so far i prefer other dissos I've tried than DMXE
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So, the 2-(pseudo)halo moiety increases how fast the drug crosses the BBB? It MAY be the case that MXE happens to be actively transported through the BBB. Usually only endogenous compounds are actively transported BUT it's possible. How the drug is distributed & then redistributed is also important.

As I noted, Parke Davis took the unusual step of patenting 5-MeO ketamine (i.e. the N-methyl analogue of MXE). Most patents are designed to cover as many compounds as possible so when I found a patent for just ONE, I was surprised. I'm prepared to bet that they were considering releasing it as a replacement for K, but drug licencing takes so long & K would have been well established before this analogue could get to the market.

I am guessing the person who designed MXE saw the patent.


https://doi.org/10.1111/cns.12099
 
Dude you have such an amazing posts and although i lack decent chemistry knowledge i appreciate reading them. I mean to be pretty honest the RC scene has been stagnating for a while now. Its mainly just about tweaking existing (RC) drugs in order to avoid breaking the law.

It's getting boring at this point. I don't need 20+ arylcyclohexylamines with minor tweaks. I would like to see some real new inventions from various drug classes like you're pointing out. I'd love to see some phenibut/baclofen analogs with added features, or GHB analogs, perhaps dissos with opoid activity. MORE lysergamides. RC narcotics could certainly be a lot more spicy, interesting and recreational. Some pregabalin / gabapentin analog would also be great. I mean sky is the limit.

I'm tired of destroying my brain cells with these mediocre RC drugs. Mad respect for what you're doing. Is there any way these ideas could be presented to netherlands / chinese RC manufacturers?
 
fugme said:
Dude you have such an amazing posts and although i lack decent chemistry knowledge i appreciate reading them. I mean to be pretty honest the RC scene has been stagnating for a while now. Its mainly just about tweaking existing (RC) drugs in order to avoid breaking the law.

It's getting boring at this point. I don't need 20+ arylcyclohexylamines with minor tweaks. I would like to see some real new inventions from various drug classes like you're pointing out. I'd love to see some phenibut/baclofen analogs with added features, or GHB analogs, perhaps dissos with opoid activity. MORE lysergamides. RC narcotics could certainly be a lot more spicy, interesting and recreational. Some pregabalin / gabapentin analog would also be great. I mean sky is the limit.

I'm tired of destroying my brain cells with these mediocre RC drugs. Mad respect for what you're doing. Is there any way these ideas could be presented to netherlands / chinese RC manufacturers?
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No problem - sorry to disturb you.

Yes, I have almost all of the things you mentioned covered.... apart from phenibut. I'm concerned that it's safety (based on known risks of baclofen) and it's dependence-liability haven't been explored. It's EASY to design analogues/homologues, but predicting safety is hard.... and most people won't pay/spend time one a full trial.
 
Feretile said:
So, the 2-(pseudo)halo moiety increases how fast the drug crosses the BBB? It MAY be the case that MXE happens to be actively transported through the BBB.
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The 2-halogen does confer OCT substrate activity in the case of K and 2-FDCK, but it really only becomes relevant with nasal administration. That's the only place you get high enough local concentrations for it to significantly affect absorption. OCT's are also expressed in the intestines, but 2-halogens also confer CYP2B6 affinity, and this contribution dominates with oral administration.
 
Ah, so the 2-halogen increases it's affinity as a substrate. So, delocalisation of electrons on aryl plays a part. It explains why a -Me won't work. So, with a methoxy para, it's going to delocalize more.

A VERY nice insight ecstacylover.

MXE is a VERY specific compound. So, the thianes, then?
 
fugme said:
perhaps dissos with opoid activity
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I'm pretty sure MXE and to some degree 3-ho-pce/pcp do this. I thought I read it somewhere... also, MXE felt better than most opioids I've taken, on par with methadone, which also has NMDA agonism. The ways in which opioids and dissos work are similar yet different, but I'm fairly certain of some minor crossover there. My month of methadone abuse, I would get a drip in my throat for some reason, that tasted like an MXE drip... weird. Just my 2C.
 
Yes - a meta -OH moiety increases mu affinity a great deal. I do not know how much of MXE is o-demethylated but as well all know, 3-OH PCP is (was) known for opiate activity. Of course, only the (S) enantiomers of ketamine analogues have NMDA affinity. The (R) isomers are DRIs. I was once given a sample of (R) ketamine and it seemed a lot like cocaine to me.... I do not like or enjoy cocaine, but it felt the same from my limited experience.
 
Feretile said:
No problem - sorry to disturb you.

Yes, I have almost all of the things you mentioned covered.... apart from phenibut. I'm concerned that it's safety (based on known risks of baclofen) and it's dependence-liability haven't been explored. It's EASY to design analogues/homologues, but predicting safety is hard.... and most people won't pay/spend time one a full trial.
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What are the dangers of baclofen? IME its very benign drug with low addiction tolerance. Benzos are waaaaay worse. Is it solely about potential toxicity of analogues?

I mean we gotta kick phenibut up a notch is all i'm saying.
 
fugme said:
What are the dangers of baclofen? IME its very benign drug with low addiction tolerance. Benzos are waaaaay worse. Is it solely about potential toxicity of analogues?

I mean we gotta kick phenibut up a notch is all i'm saying.
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Principally toxicity but since all of these analogues ARE GABA with a lipophilic group added, they are also crude. I wouldn't look at GHB analogues for the same reasons.
 
I took a look at related classes a while ago. I guess HOCPCA is likely to be PRETTY selective. That assumes that the chemist resolves the enantiomers. If memory serves, there is some more recent work that attempts to elucidate the receptor site further. Halogenated variants are also known. If these just make the compound more lipophilic or change it's activity wasn't disclosed. Potential epilepsy, depression and dependency-treating medication - in other words 'well, it does SOMETHING'.
 
Philipp Batz said:
How was it?
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Insufflated 15-20mg. Was also on a usual stack of CBD, some supplements, 10ug of LSD (trying microdosing every 3 days), and 10mg of script Dexedrine.

It felt like ketamine, but more euphoric, somewhat stimulating, and less loss of motor control. Primary effects were from 15mins after insufflating until maybe an hour after, but after effects persisted for quite a while.
I'd imagine that higher doses would feel like combining Ketamine and MDMA. Will test a higher dose soon.
Depression + anxiety (was in the midst of a rather annoying depressive episode that refused to go away, and I get bad social anxiety during depressive episodes) were completely gone afterwards and are still pretty much gone 2 days later.
I see a lot of potential for MXE and DMXE as antidepressants. Seem to work a bit better than Ketamine for me.
 
DMXE definitely impaired motor function way less than ketamine for me, and was just warmer all-around. It also had this malleability that was allowed for a hole if you directed your attention internally, but if you directed your attention externally you felt relatively sober. Sort of reminded me of MPT in that regard, whose effects were quite prominent when you focused upon them, but almost imperceptible when moving around.

Still, I think DMXE is much closer to ketamine in its headspace than to MXE. For me, things which come closest to MXE's headspace are MXiPr and especially MXPr. The plateau of 3-MeO-PCE also has a strong resemblance to MXE's plateau which makes me wonder if they share metabolites. In fact, it's been shown that 3-MeO-PCP metabolism can result in multiple hydroxylations at the cyclohexyl ring (so probably 3-MeO-PCE's can as well) and MXE metabolism can result in reduction of the ketone. So they very likely produce an identical metabolite and the question is really just a quantitative one.
 
First experience. 30mg ingested plus 20mg insufflated one hour later. Nothing special, little extremity incoordination and mood uplifted. No hungry suppression. Disappointed in some way, maybe too old (43) for being surprised by grey market drugs.
 
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