hamhurricane
Bluelighter
^^^^^
where did that info about DNA come from?
It would seem that there is a pretty clear correlation between duration of effects and degree of tolerance.
DMT>no tolerance
5-meo-dmt>no tolerance
salvia (a different receptor set, i know)>no tolerance
4-ho-dmt>"average" tolerance
DOC>massive tolerance
Br-Dfly>massive massive tolerance???
I would assume this tolerance is both a result of 5-HT downregulation, and psychological tolerance or habituation to the effects of a drug which gives you over ten hours to settle down and get comfortable.
where did that info about DNA come from?
It would seem that there is a pretty clear correlation between duration of effects and degree of tolerance.
DMT>no tolerance
5-meo-dmt>no tolerance
salvia (a different receptor set, i know)>no tolerance
4-ho-dmt>"average" tolerance
DOC>massive tolerance
Br-Dfly>massive massive tolerance???
I would assume this tolerance is both a result of 5-HT downregulation, and psychological tolerance or habituation to the effects of a drug which gives you over ten hours to settle down and get comfortable.