Dang, if 20 mg had no effect you may want to check either your tolerance, quality of the chemical, or combinations. If you're dosing once per week, maybe try taking 2-4 weeks off. It's possible what you have is degraded or maybe even adulterated. And typically nootropics will enhance or be benign on the effects of psychedelics, but maybe there is some inhibition from the coluracetam. Just be careful with dosing if you do switch up any of the variables, I am slightly sensitive to psychedelics and dose fairly lightly, but I think any of those doses would be extremely uncomfortable for me and many others.
I have no reason to believe the lack of effect from 5-MeO-MiPT has to do with anything other than the (presumably) short-term, reversible tolerance of this substance. The evidence for any of the substances I'm currently using inhibiting the effects of psychedelics is non-existent, and my attempts to prove otherwise have been entirely futile. The chance of degradation or adulteration are next to nothing, given my source's strong track record. I have full confidence what I have is in fact 5-MeO-MiPT, and that the purity equals or surpasses what might typically be expected of a professional organization.
I feel I should have been more clear in my above post when I mentioned that 20mg "yielded no results." When I say results in this case, this is only to say that I experienced nothing further than stimulation and a fairly pronounced body high. No psychedelic effects were present in that instance, or possibly I just wasn't looking hard enough to notice them. I have a fairly easy time psychologically tuning out some of the effects of psychedelics in times of extreme distraction, namely the few days after taking a high dose of this substance. so it's possible I may have conveyed the psychedelic effects as being much weaker than they actually were.
As far as how I approach dosing, I've been away from psychedelics for a few years now, and have only gotten back into it this past year with my dissociative experiences and worsening psychological health (almost entirely resolved in no small part thanks to 5-MeO-MiPT, fortunately), but in general, I tend to be cautious. Still, if I feel that I need to step things up a bit, I tend to throw caution out the window and step up the dosage tremendously despite how obviously reckless a decision this is. Still, I always stay below the toxic threshold, so most of the remaining dangers lie in the psychological aspect of the experience.
Hopefully that clears things up. I had a VERY interesting experience combining 5-MeO-MiPT with nootropics recently which I'll be sure to write a proper Trip Report on soon enough. In particular, I ran across a phenomenon I'm not sure I've ever heard mentioned in the psychedelic community before, but I'm very sure of what I experienced, and am continuing to experience through the aftereffects at this very moment. It sounds very much unbelievable, and it could be that I'm misinterpreting this, but I highly doubt it. The best way to describe what I'm experiencing is to imagine a sort of "split consciousness" occurring in the speech center of the brain, where information contained within both the conscious and the subconscious/unconscious mind can be conveyed through language. In the initial instance, I was seemingly speaking in tongues, very quick verbal gibberish that soon resulted in some fragmented bits of information. This first bit focused mainly on religion, and specifically, the "speaker" (which I later recognized as the subconscious and/or unconscious part of my brain, annoying little bastard...) had said, to name a few in no particular chronological order, "The Bible is evil, the Bible is the devil, the devil is everywhere, both above you and below your feet, the world is the devil, the world is inherently evil." Being not a theist, an atheist (as of just a few months ago), or an agnostic (it's complicated), I was a bit shocked to hear a voice mention this. It seemed to be using my voice to communicate, and it's important to note that, unlike with the possibly related phenomena occurring later on in the trip, this voice seemed to be directly communicating with me, that I was somehow in danger of Satan himself doing harm to me. I was inclined to agree with what it said at first despite being fairly skeptical about this sort of thing, but the strongly pessimistic attitude and the schizophrenic presentation led me to dismiss its existence as nothing more than irrational fear and paranoia. At first, I wasn't strongly inclined to think this was strictly a product of my mind, but assessing the experience afterwards led me to favour this possibility over the rest, most of which would be certain not to follow an evidence-based approach. I hadn't thought remaining awake for 3 days on amphetamine and PRL 8-53 would result in a psychosis progressing this quick, but I had failed to consider that a stimulating psychedelic affecting the mind so strongly as 5-MeO-MiPT would certainly have acted as the anchor to tip the boat in this instance. I feel very much lucid and mostly awake, but despite this, the "voice" I had been hearing was likely the product of psychosis rather than a profound effect induced by this wonderful little substance. The second, likely related phenomenon, however, cannot necessarily be ruled out as psychosis without a strict, thorough analysis into the matter, in my opinion. This second occurrence was quite different in nature, but perhaps even more interesting than the first. I noticed that, when I spoke, I had two options: I could call upon my subconscious/unconscious mind and speak through them - to be more precise, I had chosen to allow my voice box to transmit the information from my subconscious/unconscious mind, but I wasn't consciously aware of any of the information being conveyed prior to this. Still, when bits of information presented themselves in some vaguely coherent fashion, I'd recognize their origin. For example, I've been watching House, M.D. quite a bit lately, so my subconscious has likely been focusing a bit more on that than on other topics. Many of the bits of information rolling off of my tongue were short quotes from House, almost entirely word-for-word, and when a certain character would be involve, especially prominent with the character of Dr. Chase, who, being Australian, caused me to speak in an Australian accent quite well, whereas normally I'd be horrible at reproducing accents. Other bits of information included hundreds if not thousands of complicated medical terms I'd never consciously retain without exerting a tremendous amount of effort, most but not all of which were originally heard on House, but some may even have had their roots back in my late childhood, a significant length in time to be recalling without some major outside influences (like a high dose psychedelic, for example.) Most interestingly though, I've heard quite a few references to various types of aliens, almost as if they were intending to "abduct" me, but I think it's best to write this off as another paranoid delusion brought on by the amphetamine psychosis. I'd say the information being transmitted from my subconscious/unconscious mind is very much real, but the way I had framed it is far from reality. Lastly, some of the information I've transmitted has been highly suggestive of some type of telepathic communication, almost a literal "mindrape," if you will, though not deliberate by any means if this did in fact occur. I find this all very interesting, and after doing a write-up on my experiences as soon as time permits, I'll be sure to dedicate myself to figuring out just what the hell happened today. This may just be the strangest psychedelic experience I've ever heard of, let alone experienced, and I haven't quite taken it all in yet. I'd appreciate any thoughts that aren't quick to dismiss away my experiences as paranoid schizophrenia and suggest I be prescribed antipsychotics for the rest of my life. It's a strong possibility this is a new possibility opened up by 5-MeO-MiPT, and it would be a shame if this all were to be boiled down to pseudoscience and the like.
For reference's sake, the dosages used are as follows:
20mg 5-MeO-MiPT
10mg PRL 8-53 (dosed ~2 hours earlier than any other substances)
30mg Coluracetam
1.6g Piracetam
60mcg Methylene Blue
250mcg Clonazepam (dosed the day before any other substances, about 10:00AM or so)
4mg Intuniv (dosed at the same time as clonazepam, the day before this trip took place)
4.5mg C60oo
500mg Cephalexin (for strep throat, checked for interactions and only my usage of a 14-Mushroom Blend had to be ceased, due to containing Reishi as one of the ingredients)
And of course, let's not forget that I had stayed up for 3 days straight and counting using dextroamphetamine and PRL 8-53, the former of which can definitely cause psychosis in those instances, and the latter of which could carry similar dangers, due to being a dopamine agonist as well. Whether or not this action is present in PRL to any degree comparable to dextroamphetamine, I'm not sure. Rather, I'm mentioning this based on nothing more than speculation.
This has been an intense morning. I'm going to keep up with this and see if anything else unfolds. I have to admit, this flooding of information from the unconscious is as entertaining and interesting as it scary to experience. Speaking at nearly 10 words per second is simply hilarious to listen to while tripping. I'll do what I can to stay safe with the application of some general HR advice, but there's not exactly anything specific to the split consciousness phenomena that I could find. Has anyone else experienced this, or heard about it anywhere? A lot of things are unclear to me surrounding this whole situation, but two things are clear: the first is that 5-MeO-MiPT is a substance capable of far more than we had ever imagined when the first dose was consumed, just like 5-MeO-DMT in a sense I suppose, and the second is that explaining this is likely well beyond the scope of "standard" scientific fields alone to explain in full. Although neuroscience can likely explain how the unconscious mind is able to present information in the same way the conscious mind normally would, I feel the more interesting aspects of this experience are more closely bound to quantum-based methods, like the seeming accidental "mind invasion" I had perpetrated, the "trapped" beings that made pleas for help through my unconscious mind, and the temporary induction of xenoglossy. This all sounds like magic, for lack of a better word, but I know what I experienced and it's definitely a very real thing. If anyone knows anything, please, send me a PM if you will. Thanks.