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The Big & Dandy 5-IT / 5-API Thread

Guess it's horses for courses. We used to call the sedated part of MDMA 'sledging' and many compared those who liked it a bit too much to 'smackheads'.

I take the sedated period as a calm before storm (and assume it's the initial serotonin buzz). The stimulant period I find a little jittery with major bruxism etc - but as I said, I get shit done at such doses (50-60mg). So it effectively works as a functional stimulant for me (with a nice chilled buzz to start). First time I used it I watched The Globes production of Othello during the come-up - was pretty awesome (such an emotional play, heh). Then went and wrote a few thousand words for something I'd been procrastinating about.

Comparison of a few related RCs I've tried over last few months:

6-apb - non-functional head-mashing rushing euphoria with trippy edge (if you want to be mashed, works great).
IAP - sleepy and rather underwhelming, slight trippy edge (needs dopa push) - major gastro issues!
5-IT - chilled & also functional at conservative doses. Given recent reports, doubt I'd go much above such doses.

Well I know what you mean about the smackey MDMA buzz...I actually love that too. Who doesn't? I do admit now a days I'm more into speedy rolls, but when I first started, the smackey ones were the best. We were told those were the "dirty" ones with brown dots...lol they were actually the CLEAN ones which were pure strong MDMA. But the tired feeling I get with 5-IT before the roll kicks in, is not the same as MDMA. There is no serotonin to notice with it. On the sedated MDMA buzz, there is extreme euphoria. I'd also be willing to go as far as to say 5-IT is smackey, even on the peak. It doesn't really have a lot of energy. Very comparable to an MDMA roll, but even stronger in that sense. At least it does have enough energy to function or go out, if you need to. I bowled last time I was on it. And this was after walking around or being on my feet all night. So 5-IT is very flexible. Either you can sit and smack out (Which is best if you got music and weed) or you can roam around or dance/walk/talk all night on the shit. It's a cool drug, and it has benefits which I mentioned above.

To those who've tried it, how would you rank it in empathy, stimulation, euphoria, easiest comedown when compared to other similar substances?

I enjoy the different effect profiles as I find they each fit different environments better :) for example for me 6-APB is a nice party drug while 5-APB is more a relaxed at home empathic experience, with less of a euphoric push.

Rating out of 1 to 10 scale on comparison of each drug. 10 being best.

MDMA Empathy- 10
5-IT Empathy- 6

MDMA Stimulation- 7
5-IT Stimulation- 6

MDMA Euphoria- 10
5-IT Euphoria- 10

MDMA Comedown- 4
5-IT Comedown- 10 (10 being easiest)

Now I will compare to 6-apb but as we discussed before, my batch of 6-apb wasn't 100% pure, and I hear none of the 6-apb now a days compares to old anyway, but here goes just for shits and giggles-

6-apb Empathy- 1 (None for me)
6-apb Euphoria- 3 (Not much)
6-apb comedown-1 (Terrible)
6-apb stimulation- 1 (Felt lazy on it..never any urge to do anything)

Now compare to Methylone-

m1 empathy- 7
m1 euphoria- 9
m1 comedown - 5 (Would rate this higher but duration is so short, comedown can sometimes hit suddenly)
m1 stimulation- 9

---Notice how I Scored MDMA higher on most of the catagories...however I still rank 5-IT to be up there or even past MDMA. Mainly due to respect in the duration...you don't have to worry about coming down on the 5-IT. Which is my favorite part. lol also most people will enjoy the comeup before the peak because it gets stronger and stronger, but ever so gradually so that you can continue to enjoy it more and more throughout the night as time goes on...instead of less and less like MDMA, Methylone, and most other rolling drugs.
 
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I responded to that thread. I call bullshit. Water can kill you from overdose. Does that mean we should ban water? 5-IT in my opinion is a wonderful drug, which has been for me, far less toxic on the body than MDMA. This is stating from personal experience, from what I've felt..but everyone is different. 5-IT is also awesome when it comes to tolerence- It doesn't build up! I've taken it like 5 times in the past week and feel it good everytime. I do need a break now though, but I still feel great today. Worst after effects I got was dizziness, no brain zaps, no sleep paralysis, no diarrhea, nothing. I think 6-apb is far more toxic than this stuff. But to each their own, this is an awesome drug so don't believe any bullshit they tell you.

Also I'm coming out and saying it right now- 5-IT would make a GREAT "Quit Smoking" drug. Smoking causes many problems, so to eliminate that, makes 5-IT a miracle for someone who was too weak minded to quit on their own. It's hard. I've done it before, but you always get slip back into it again if you're not careful. But 5-it seriously has gotten me to practically quit without even trying. Transformation happened overnight.
 
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5-IT in my opinion is a wonderful drug, which has been for me, far less toxic on the body than MDMA.
of course, you cannot know that for sure, even if it feels "cleaner".

your problem is, you are talking shit about one drug (6-apb) and glorify another (5-it), just because of your personal experience (which is, imo, not to regard, because you eyeball all your doses, and sometimes dose multiple times a week and probably mix it with other drugs most of the time). your posts are completely devoid of any sense and also anti-harm-reduction.

think about it...
 
It sort of lies in a euphoric drugs main effects that it feels really good to be on it. If there's muscle tension or stomach pains or any other pain involved, the main effects are still covering up the less illusory body image you could have if you weren't rolling on a suspicious potent new chemical which according to Shulgin's pretty long lasting and most likely does plenty and plenty and plenty to one of the most sensitive types of neural signaling involved in recreational drug use, indiscriminate serotonin transmission from what's likely to be a release mechanism as well as SRI if I'm not mistaken.

Ask me to make any assessment, and if I'm just now swirling into developing romantic passionate feelings for someone, I'll be a bad judge. If I'm post coital, I'd be an even worse judge, I believe. And further away in that direction lies 5-IT and perhaps some other quirky ten-milligram-ticket to Lala-land. aMT maybe. And this influence isn't just a somewhat transparent curtain over your reasoning and grade of contact with bodily perception, it's a potent agent which in tiny amounts forces your brain into a tsunami kind of development, bashing all the empathy-relation-conscience-kind of buttons with greater and greater intensity. I bet it's one capable pain killer, and a specialist in temporarily disabling personal or psychological issues by activating all these connect-with-other-people-switches and keeping it coming and coming and coming.

If there's one thing a person in that state would have trouble getting interested in and at least somewhat credible as source of information about, it's the rolling fellows own body. And then comes the classical stimulant euphoria washing in, on top of everything hitherto. I wouldn't trust a friend who's on amphetamine if he says his leg doesn't hurt after he tripped during a forest walk. Because to me, stimulants are very effective in masking muscle aches, cramps, stomach cramps and other usually painful phenomena. With MDMA there's nothing hurting in my body, ever. I've crashed down stairs beating myself pretty well on a roll once, didn't feel at all bad until next morning, when I barely made it out of bed.

If there's destructive stuff going on with kidneys, liver or whatever with 5-IT which could hurt someone who's not forced into euphoric singleminded relation establishment, I have a hard time picturing someone rolling on anything MDMA-like to have even the slightest idea about what status their corpus actually is in. Then again, it ought to show up afterwards, wouldn't it? Shulgin assessed 5-IT to a duration of tens of hours if my memory serves me good enough. That's how long I wouldn't trust someones self image if there's this certain mysterious drug involved. At least. It's common with a sleepy day after a roll and then comes the blues, perhaps even another day later. I interpret this as effects lingering on for a day or two after the roll is usually considered over. Whether or not dependent on metabolites or just an imbalance in neurotransmittor availability or some odd receptor related stuff, I don't know. When it's over itches, pains, irritability, and so on is usually expected, at least I do, in any case there's a lethargic backlash which might continue to trivialize pain in body image compared to psychological self image and certain negative after effects connected to it's state and functioning.

So much, and all I'm saying is that I don't trust a drug user which claims to have found the perfect drug to be a fair judge of risks or a credible source regarding negative potential in said drug. And in this case said drug also seems to be one hell of a drug and should be treated with suspicion.

One of the deeply troublesome aspects of recreational drug use is the capacity of even quite benign drugs to surpass impartial and nuanced assessment from a user. If they weren't effective, manipulative, deceptive little demons we would have no interest in them. Because that is just one side of being happy.


Are there any valid arguments about the metabolism of this stuff out there?


Edit: Corrected some spelling and grammar. Don't tweak and drive a keyboard, might be an adequate sober assessment of my post.
 
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of course, you cannot know that for sure, even if it feels "cleaner".

your problem is, you are talking shit about one drug (6-apb) and glorify another (5-it), just because of your personal experience (which is, imo, not to regard, because you eyeball all your doses, and sometimes dose multiple times a week and probably mix it with other drugs most of the time). your posts are completely devoid of any sense and also anti-harm-reduction.

think about it...

The thing is, I have a special ability called insight and awareness. Something we should all have, a gift from god...but the devil's army has stolen this from most of us. This is why I spend pointless hours arguing with demons, to no avail. Basically you need a third eye. You need to see the things that are really there right in front of your face, or else your entire life will be just an illusion. What are hallucinations? Are they real? Of course they are. So what they tell us are hallucinations is what is really there...and what you see that is "Really" there, is just an illusion. Try some mushrooms today...before it's too late. Then come back and tell me 5-IT is not a good drug.

It sort of lies in a euphoric drugs main effects that it feels really good to be on it. If there's muscle tension or stomach pains or any other pain involved, the main effects are still covering up the less illusory body image you could have if you weren't rolling on a suspicious potent new chemical which according to Shulgin's pretty long lasting and most likely does plenty and plenty and plenty to one of the most sensitive types of neural signaling involved in recreational drug use, indiscriminate serotonin transmission from what's likely to be a release mechanism as well as SRI if I'm not mistaken.

Ask me to make any assessment, and if I'm just now swirling into developing romantic passionate feelings for someone, I'll be a bad judge. If I'm post coital, I'd be an even worse judge, I believe. And further away in that direction lies 5-IT and perhaps some other quirky ten-milligram-ticket to Lala-land. aMT maybe. And this influence isn't just a somewhat transparent curtain over your reasoning and grade of contact with bodily perception, it's a potent agent which in tiny amounts forces your brain into a tsunami kind of development, bashing all the empathy-relation-conscience-kind of buttons with greater and greater intensity. I bet it's one capable pain killer, and a specialist in temporarily disabling personal or psychological issues by activating all these connect-with-other-people-switches and keeping it coming and coming and coming.

If there's one thing a person in that state would have trouble getting interested in and at least somewhat credible as source of information about, it's the rolling fellows own body. And then comes the classical stimulant euphoria washing in, on top of everything hitherto. I wouldn't trust a friend who's on amphetamine if he says his leg doesn't hurt after he tripped during a forest walk. Because to me, stimulants are very effective in masking muscle aches, cramps, stomach cramps and other usually painful phenomena. With MDMA there's nothing hurting in my body, ever. I've crashed down stairs beating myself pretty well on a roll once, didn't feel at all bad until next morning, when I barely made it out of bed.

If there's destructive stuff going on with kidneys, liver or whatever with 5-IT which could hurt someone who's not forced into euphoric singleminded relation establishment, I have a hard time picturing someone rolling on anything MDMA-like to have even the slightest idea about what status their corpus actually is in. Then again, it ought to show up afterwards, wouldn't it? Shulgin assessed 5-IT to a duration of tens of hours if my memory serves me good enough. That's how long I wouldn't trust someones self image if there's this certain mysterious drug involved. At least. It's common with a sleepy day after a roll and then comes the blues, perhaps even another day later. I interpret this as effects lingering on for a day or two after the roll is usually considered over. Whether or not dependent on metabolites or just an imbalance in neurotransmittor availability or some odd receptor related stuff, I don't know. When it's over itches, pains, irritability, and so on is usually expected, at least I do, in any case there's a lethargic backlash which might continue to trivialize pain in body image compared to psychological self image and certain negative after effects connected to it's state and functioning.

So much, and all I'm saying is that I don't trust a drug user which claims to have found the perfect drug to be a fair judge of risks or a credible source regarding negative potential in said drug. And in this case said drug also seems to be one hell of a drug and should be treated with suspicion.

One of the deeply troublesome aspects of recreational drug use is the capacity of even quite benign drugs to surpass impartial and nuanced assessment from a user. If they weren't effective, manipulative, deceptive little demons we would have no interest in them. Because that is just one side of being happy.


Are there any valid arguments about the metabolism of this stuff out there?


Edit: Corrected some spelling and grammar. Don't tweak and drive a keyboard, might be an adequate sober assessment of my post.


You wrote all that just to make a point that you do not trust me? WoW! lol I think it's obvious to most people, not to trust anyone on the internet. I don't expect anyone to trust me. And even if they had trusted me, it doesn't mean the drug is going to work wonders for them, as it has for me. Bottom line is, the legal drugs are the drugs you need to worry about. They have been programmed to destroy your brain and body. The illegal drugs and nutrients are mostly good for you...that is WHY they are illegal. Mushrooms and Pot are the safest substances known to man, both are illegal. Why? Because Pot is a medicinal herb, and both make you think for yourself. This would be deadly to them. So, basically you cannot overdose on either one, I've taken both in extreme quantities.

So, you've made your points, of course you have an afterglow and feel good the next day. I've been doing 5-IT long enough to know what the 3rd and 4th days feel like. They are fine. I've taken MDMA and 6-apb before and all 5-IT is, is like 6-apb with a less trippy side and more of an MDA feel. All are closely related. However I can strongly say (Even with no proof) that MDMA is much worse for your brain than 5-IT. And worse for your liver as well. There are too many factors involved with illegal drugs to put the blame on any certain thing. Besides, Why would I worry about the future, when we are not even guaranteed to survive the next trip we take down the street? Worry about some "illegal" drug, just because it is a painkiller? Of course MDMA kills pain, I love getting punched/slapped in the face when I'm rolling. Pain is pleasure if you're on that level. I remember my "friend" put a cigarette out on my arm while I was driving. It didn't even hurt, it felt good like a sensation. But if I was sober it would of hurt like a bitch cuz I did that once to myself when I was a kid.

OK Peace and be safe, if you're afraid of 5-IT and you're afraid to live...then limit yourself and don't try it. Also I would recommend against leaving your house as well. Lots of dangerous things out there in the world...and the big 5-IT monster may just eat you alive. Lmao...

Ok, Ok, in all seriousness...Even if I do grow tentacles out of my ears in the future, I'll just try to look on the bright side...and 5-IT is so good, it would be worth it anyway.
 
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The thing is, I have a special ability called insight and awareness. Something we should all have, a gift from god...but the devil's army has stolen this from most of us. This is why I spend pointless hours arguing with demons, to no avail. Basically you need a third eye. You need to see the things that are really there right in front of your face, or else your entire life will be just an illusion. What are hallucinations? Are they real? Of course they are. So what they tell us are hallucinations is what is really there...and what you see that is "Really" there, is just an illusion. Try some mushrooms today...before it's too late. Then come back and tell me 5-IT is not a good drug.




You wrote all that just to make a point that you do not trust me? WoW! lol I think it's obvious to most people, not to trust anyone on the internet. I don't expect anyone to trust me. And even if they had trusted me, it doesn't mean the drug is going to work wonders for them, as it has for me. Bottom line is, the legal drugs are the drugs you need to worry about. They have been programmed to destroy your brain and body. The illegal drugs and nutrients are mostly good for you...that is WHY they are illegal. Mushrooms and Pot are the safest substances known to man, both are illegal. Why? Because Pot is a medicinal herb, and both make you think for yourself. This would be deadly to them. So, basically you cannot overdose on either one, I've taken both in extreme quantities.

So, you've made your points, of course you have an afterglow and feel good the next day. I've been doing 5-IT long enough to know what the 3rd and 4th days feel like. They are fine. I've taken MDMA and 6-apb before and all 5-IT is, is like 6-apb with a less trippy side and more of an MDA feel. All are closely related. However I can strongly say (Even with no proof) that MDMA is much worse for your brain than 5-IT. And worse for your liver as well. There are too many factors involved with illegal drugs to put the blame on any certain thing. Besides, Why would I worry about the future, when we are not even guaranteed to survive the next trip we take down the street? Worry about some "illegal" drug, just because it is a painkiller? Of course MDMA kills pain, I love getting punched/slapped in the face when I'm rolling. Pain is pleasure if you're on that level. I remember my "friend" put a cigarette out on my arm while I was driving. It didn't even hurt, it felt good like a sensation. But if I was sober it would of hurt like a bitch cuz I did that once to myself when I was a kid.

OK Peace and be safe, if you're afraid of 5-IT and you're afraid to live...then limit yourself and don't try it. Also I would recommend against leaving your house as well. Lots of dangerous things out there in the world...and the big 5-IT monster may just eat you alive. Lmao...

Ok, Ok, in all seriousness...Even if I do grow tentacles out of my ears in the future, I'll just try to look on the bright side...and 5-IT is so good, it would be worth it anyway.

Yeah, I did. For a good reason, to show why your personal experience isn't a credible source of information regarding the safety and possible toxicity of 5-IT on a general level and why your claim that this is a perfectly safe drug in itself is pretty much worthless to the rest of us.

As you can see I put some effort into explaining my perspective on autoreports in general with specific regard to euphoric drugs, which clearly has nothing to do with you as a person or the content of statements your making. This obviously needs to be pointed out to you, since your response delves in large part on you yourself as an issue of the discussion.

You've made some claims, among which are that this drug is perfectly safe because you happen to be an outspoken drug abuser not dead yet and that some conspiracy in Sweden faked these deaths or the autopsy results for some reason you're either ignorant of or failed to share in context. Instead you went on blabbering about how the victims if there really was any had it coming due to ignorance/stupidity and stating that everyone's stupid but you. Stating that just about everyone but you are ignorants. This is how you argue. With either reference to your own anecdotes or your values, or simplistic explanations based on everyones inferiority to you or some capacity of yours.

Compare that to my kind of argument, where the reasoning is based on well known facts about some things in general. Do you see the difference? Can you comprehend the idea of common ground as a solid base for an argument and why this is way superior to the I'm-all-that-matters-approach you've been practicing with? Are you able to follow how the connection between well known and undisputed facts and the effect on credibility of what's stated next if it complies with said facts?

I'll just ignore my personal views and assume you do. As you may or may not have noticed I put my self as an example of someone lacking credibility given a few conditions. Plenty of room in my post shows me off as an example of what you as an autoreporter appeared to be. Plain. No ridiculing. I didn't even touch on the subject that your posts somehow are meticulously stripped of anything resembling confident, classic step-by-step reasoning, the 101 of convincing thought patterns and kindergarten rhetoric.

Showing myself to be at least as faulty an autoreporter as I claimed everyone else to be and pointing out that basic stuff all of us druggies know very well concludes that your assessment of a drug apparent to be the force behind not only your assessed experiences but the importance ascribed to your interpretation as well. Arguing in this way is clearly invalid. The drug can't both be reason for your experience and the basis for credibility of your report at the same time. Bias is at the heart of this, 'the drug experience' resulting in assessment 'the drug is safe' which you are telling us to believe in because the drug experience to you implies what the assessment states and again 'the drug experience' surfaces as your preferred reliance.

Not only is your assessment a reworking of a drug dependent experience, you have been shown why that experience needs to be doubted as a source of general knowledge about the drug itself which you blatantly refuted with reference to the drug dependent experience which still cannot be trusted because of it's drug dependent status. This shows your relation to this drug, your minds dependence on it even when that same drug is clearly shown to have been depleted as a relevant source of assessment support at the very moment your interpretation and safety assessment was made, it is the effect of the drug that you believe is real and quote for truth.

Thats about how empty your contribution to the common routine for mapping new drugs really is. Thank you for the time and effort spent on my shot at explaining why there's such a lack of supporters for your case as an amateur safety assessment reporter.




I've tried to boggle my grey over the molecule and have contented with ungrounded guesses about possible enzyme targets in it. Meager result indeed. Anyone else feeling courageous enough to just make something up to continue with?

There are some aspects of the drug experience which I find a bit disturbing. First, how does it accomplish this series of effects: threshhold->serotonin buffing up->gliding over to dopaminergic activity as well->still rising even though past more than half the duration->plateau with a dissociation getting hinted at by mister unsuitable for reporting->weird start of the first fading phase, everything at once->perceptual subjective baseline->and then there's more going on at a slow fading pace->end. It's one substance. Either it becomes several or it operates many different levers and locks. In any case, why does euphoria kick in at a random point in the build up of the serotonin curtain just like that with no change in other processes. Is it the same kind of phenomenon operating when it goes plateu with a wisp?

If it cleaves early, where would you like to split it (stomach, liver, are there more) and what in vivo synthesis may new drugs appear as by products? Is this proposal even sane given for example a freshman year of biology?

It might grow in the body, fetching a more versatile range of elements or chemical molecylar components. Seems unlikely, right?

If it cleaves or just breaks down to another monoamine later on in process, would this feel like a grave concern regarding safety and the progress, yeah.

We have somewhat related drugs, the APB:s. One is skimmed by bya science team which leaves us at square one. Those to work in slightly different directions Why is one trippy and not the other? Receptor affinity or bonking with neurotransmitter streams.

Are these three substances susceptible to MAO? What do you think?
 
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Yeah, I did. For a good reason, to show why your personal experience isn't a credible source of information regarding the safety and possible toxicity of 5-IT on a general level and why your claim that this is a perfectly safe drug in itself is pretty much worthless to the rest of us.

As you can see I put some effort into explaining my perspective on autoreports in general with specific regard to euphoric drugs, which clearly has nothing to do with you as a person or the content of statements your making. This obviously needs to be pointed out to you, since your response delves in large part on you yourself as an issue of the discussion.

You've made some claims, among which are that this drug is perfectly safe because you happen to be an outspoken drug abuser not dead yet and that some conspiracy in Sweden faked these deaths or the autopsy results for some reason you're either ignorant of or failed to share in context. Instead you went on blabbering about how the victims if there really was any had it coming due to ignorance/stupidity and stating that everyone's stupid but you. Stating that just about everyone but you are ignorants. This is how you argue. With either reference to your own anecdotes or your values, or simplistic explanations based on everyones inferiority to you or some capacity of yours.

Compare that to my kind of argument, where the reasoning is based on well known facts about some things in general. Do you see the difference? Can you comprehend the idea of common ground as a solid base for an argument and why this is way superior to the I'm-all-that-matters-approach you've been practicing with? Are you able to follow how the connection between well known and undisputed facts and the effect on credibility of what's stated next if it complies with said facts?

I'll just ignore my personal views and assume you do. As you may or may not have noticed I put my self as an example of someone lacking credibility given a few conditions. Plenty of room in my post shows me off as an example of what you as an autoreporter appeared to be. Plain. No ridiculing. I didn't even touch on the subject that your posts somehow are meticulously stripped of anything resembling confident, classic step-by-step reasoning, the 101 of convincing thought patterns and kindergarten rhetoric.

Showing myself to be at least as faulty an autoreporter as I claimed everyone else to be and pointing out that basic stuff all of us druggies know very well concludes that your assessment of a drug apparent to be the force behind not only your assessed experiences but the importance ascribed to your interpretation as well. Arguing in this way is clearly invalid. The drug can't both be reason for your experience and the basis for credibility of your report at the same time. Bias is at the heart of this, 'the drug experience' resulting in assessment 'the drug is safe' which you are telling us to believe in because the drug experience to you implies what the assessment states and again 'the drug experience' surfaces as your preferred reliance.

Not only is your assessment a reworking of a drug dependent experience, you have been shown why that experience needs to be doubted as a source of general knowledge about the drug itself which you blatantly refuted with reference to the drug dependent experience which still cannot be trusted because of it's drug dependent status. This shows your relation to this drug, your minds dependence on it even when that same drug is clearly shown to have been depleted as a relevant source of assessment support at the very moment your interpretation and safety assessment was made, it is the effect of the drug that you believe is real and quote for truth.

Thats about how empty your contribution to the common routine for mapping new drugs really is. Thank you for the time and effort spent on my shot at explaining why there's such a lack of supporters for your case as an amateur safety assessment reporter.




I've tried to boggle my grey over the molecule and have contented with ungrounded guesses about possible enzyme targets in it. Meager result indeed. Anyone else feeling courageous enough to just make something up to continue with?

There are some aspects of the drug experience which I find a bit disturbing. First, how does it accomplish this series of effects: threshhold->serotonin buffing up->gliding over to dopaminergic activity as well->still rising even though past more than half the duration->plateau with a dissociation getting hinted at by mister unsuitable for reporting->weird start of the first fading phase, everything at once->perceptual subjective baseline->and then there's more going on at a slow fading pace->end. It's one substance. Either it becomes several or it operates many different levers and locks. In any case, why does euphoria kick in at a random point in the build up of the serotonin curtain just like that with no change in other processes. Is it the same kind of phenomenon operating when it goes plateu with a wisp?

If it cleaves early, where would you like to split it (stomach, liver, are there more) and what in vivo synthesis may new drugs appear as by products? Is this proposal even sane given for example a freshman year of biology?

It might grow in the body, fetching a more versatile range of elements or chemical molecylar components. Seems unlikely, right?

If it cleaves or just breaks down to another monoamine later on in process, would this feel like a grave concern regarding safety and the progress, yeah.

We have somewhat related drugs, the APB:s. One is skimmed by bya science team which leaves us at square one. Those to work in slightly different directions Why is one trippy and not the other? Receptor affinity or bonking with neurotransmitter streams.

Are these three substances susceptible to MAO? What do you think?


OK in all seriousness, you make some good points. No one can really say for sure how safe the drug is...if I came off like I was guaranteeing this drug is safe, then I apologize. In no way do I know for certain. I would not be surprised if it turned out to harm your liver. Most drugs are bad for your liver. Just saying it's not like MDMA where I can feel the damage the next day, or even the next week. It's not like MDMA where you can't do it everyday. This is more like tripping. I Really do have awareness, and that is why I seem so confident in what I say. I believe 5-IT is safer than MDMA because of these facts, and also it is just obvious to me when you can do something without your body giving you any warning, then you know it can't be that dangerous. Your body is smart and will tell you if something isn't right. I don't get that feeling with 5-IT. And most people are saying it is their favorite RC...hardly anyone is getting any bad side effects at all from the drug. So that's all I'm saying. I wrote most of my posts sober or with a clear mind. I may of done a live trip report, but not really from what I remember, I edited it the next day. If you don't want to try the 5-IT that's fine...but in that case, why risk trying anything?

I figure people here know the risk they are getting into when they try a new drug. No matter what people report, everyone could react differently, so I think people are aware of that. I didnt have any intention of making anyone believe any different...and I do not think my posts would persuade anyone to believe the drug is guaranteed safe. And the word "Safe" can be left open to different meanings/definitions as well. To me "Safe" would mean a very unlikely way to die. Driving would be considered far more dangerous than 5-IT ever will be and we do that everyday. In my post, I was Just trying to make obvious points to why I think it is much easier on your body than MDMA. It has almost the same magic as MDMA at points, but weaker and slower released. I think this could explain why you dont get the bad side effects, cuz it's much more gradual, and therefore it doesn't "Shock" your brain. I've had no brain zaps, or anything. (And I definitely don't think I'm the smartest person out there when it comes to drugs. I've done some of the dumbest shit, you wouldn't believe) I'm confident in what I say and feel, so I may come off that way but I'm not really that narcissistic. I believe we're all equal, which I'm sure you know that too, if you've ever done MDMA before...
 
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Okay, just coming in to sort a few things out here.

First - no abuse guys, if you think a post doesn't belong, or someone attacks you, use the report button, don't retaliate/resort to flaming! I would normally issue warnings/infractions to all involved parties but I can see this is all arising over personal differences in effects and not anyone directly trying to attack each other. In this case I've just removed the posts, but let's keep things civil please.

I do think we need to tone down the back and forth debate too. Unlike the 6-APB thread, from everything I know I'm inclined to side with KOB this time that this is likely quite a worthwhile substance - I wouldn't say you should approach it looking for an MDMA substitute, but if you're into that whole area of substances I suspect this one would be enjoyable too.

That said though, the debating back and forth doesn't really help since, as you rightfully mentioned, everyone reacts differently. It's worth posting your experiences and opinions, but they only really need mentioning once - of course, feel free to ask each other questions about the experiences and such but arguing over the enjoyability of the drug - and the safety, particularly when it's new and unresearched, is just going to lead to a lot of wasted time typing from both parties ;)

Regarding the safety, if like 5-APB, 5-APDB and 5-APDI this follows the trend of being mostly serotonergic, I would hazard a guess that it'd be a little safer than MDMA. That said, MDMA's safety depends on keeping use infrequent, doses low, and avoiding repeated redoses.. Once it becomes a regular thing MDMA goes from being one of the safer compounds to one of the most damaging, so something *possibly* being safer than MDMA doesn't mean it's safe in the slightest either.

Like all these drugs I don't think using this more than once a month is advisable. At the very least using it more frequently is going to cause cross tolerance with other serotonin and dopamine releasers, but there's also the potential for neurotoxicity as with MDxx.

Just be careful guys :)

By the way KOB we don't allow live trip reports here, it gets really messy and besides trip reports belong in the appropriate forum. It's nice to see a report up though, maybe you could have a quick proofread, see if it's how you want it to be, choose an appropriate title and I could send it over to Trip Reports, and post a link to the report back here once it's moved?
 
^ It seems rather irresponsible and groundless, especially as a moderator, to voice assumptions that this compound is "safer than MDMA" when it has been implicated in many deaths (at least 14) in Sweden as of late, and countless horrific sounding overdoses, as described in the press and on flashback.org. I'm not saying this compound is assuredly dangerous, but in the spirit of harm reduction it pays to play it safe, and base our conclusions on facts, and not assumptions. Just because it is primarily serotonergic (we assume), and doesn't suffer from the added neurotoxicity of throwing DA efflux into the equation etc, (we assume) doesn't mean it is safe. It could very well also inhibit MAO in high doses, or dual RA/RI, or cause extreme vasoconstriction. We just don't know yet. Maybe the deaths are due to mixtures, or overdoses. We don't know, and so we should assume nothing.
 
People seem to forget that all the major stories about deaths from rc`s have all been lies!

Like the meph deaths the 6apb death and even the leah Betts story about dying from one ecstasy tablet.

All false

Every single one.

So why does anyone give any credibility whatsoever to this latest `14 deaths` story?

It is garbage and will be proved so in the coming months just like all the rest.

Propaganda at it`s best lol
 
People seem to forget that all the major stories about deaths from rc`s have all been lies!

Like the meph deaths the 6apb death and even the leah Betts story about dying from one ecstasy tablet.

All false

Every single one.

So why does anyone give any credibility whatsoever to this latest `14 deaths` story?

It is garbage and will be proved so in the coming months just like all the rest.

Propaganda at it`s best lol

Reminds me of this article
Remember...all the "real" journalists are on vacation. There's even more bullshit in the media than ususal.
Think for your self people...how come only Swedes die of this drug?
 
Reminds me of this article
Remember...all the "real" journalists are on vacation. There's even more bullshit in the media than ususal.
Think for your self people...how come only Swedes die of this drug?

there is no country on earth with media as full of bullshit as the UK, with the Sun at the top. Hardly an apt comparison. There are many good reasons (cultural, legal, social) why many "RC" deaths seem to happen in Sweden first. Some of these incidents make their way into journals, as they develop the screening first. I won't doubt if more deaths have happened elsewhere (they have) but aren't being screened for. I don't suggest that 5-IT is deadly bar none, but is appears to have a low safety margin. Look at the reports of overdose in this thread. Extreme hyperthermia and confusion. Look at the documented deaths from methylone, MDMA, etc. Extreme hyperthermia and confusion. Notice anything? This is called acute serotonin toxicity. So, if these reports all are propaganda, what's up with the dozens upon dozens of reports on flashback.org detailing Swedish deaths and overdoses. All propaganda too? How do they do that?

This anti-media hysteria is equal parts laughable and depressing. Sure, the mainstream media can do some questionable things, but this does not make it all moot, nor does it make fringe loons like Alex Jones credible. Think for yourself but don't forget to think.
 
^ It seems rather irresponsible and groundless, especially as a moderator, to voice assumptions that this compound is "safer than MDMA" when it has been implicated in many deaths (at least 14) in Sweden as of late, and countless horrific sounding overdoses, as described in the press and on flashback.org. I'm not saying this compound is assuredly dangerous, but in the spirit of harm reduction it pays to play it safe, and base our conclusions on facts, and not assumptions. Just because it is primarily serotonergic (we assume), and doesn't suffer from the added neurotoxicity of throwing DA efflux into the equation etc, (we assume) doesn't mean it is safe. It could very well also inhibit MAO in high doses, or dual RA/RI, or cause extreme vasoconstriction. We just don't know yet. Maybe the deaths are due to mixtures, or overdoses. We don't know, and so we should assume nothing.

Oh no don't get me wrong. My post was trying to point out that while the compound's structure suggests it could be a little safer than MDMA, MDMA isn't inherently safe and is certainly something that causes significant damage when taken too often or in too high doses.

It's worth mentioning that alongside this, we should treat it as more dangerous than MDMA/MDA at the moment since these are the closest compounds with any research data - any precautions taken for MDMA and MDA should most definitely be taken this, but more room for error should be given as at least with MDMA and MDA there is data out there and we know most of the risks - with this we don't.
 
I understand your reasoning but the current evidence suggests otherwise. The neurotoxicity of MDMA is understood to stem partially or entirely from its metabolites and 5-API cannot be metabolized in the same manner if at all (reductive amination excluded). Triple releasers of similar structures have been demonstrated to be non-neurotoxic so while I'm not suggesting to use this drug more than once a month (or at all), it is probably a lot safer than MDMA/MDA and hence in the purpose of harm reduction it is almost certainly advisable to select this or any other proven non-neurotoxic entactogen.
 
But other, "non-MDMA" mechanisms for toxicity are conceivable and possible.
 
Maybe the slow comeup is due to absorption issues. Has anyone tried mixing this with an acid (I think the indole means it will absorb better under acidic conditions)?

Dissolved some 5-IT in concentrated lemon juice. Didn't seem to influence the length of the come-up though.
 
^ I'm not saying this compound is assuredly dangerous, but in the spirit of harm reduction it pays to play it safe, and base our conclusions on facts, and not assumptions.

FACT: Just being alive and breathing in today's day and age (End times, WW III, etc) is far more dangerous than 5-IT could ever dream to be.

ASSUMPTION : 5-IT could be dangerous because of "Reported" deaths.


Actually I did not know that every single one of the reports was a lie. I heard of the leah betts story...with her drinking too much water, and I believed it. I know there is tons of prop. out there, but I always figured they mix in lies with truth to make it more confusing. I remember seeing "Leah's Mom" getting interviewed or something, so I just believed it was true as most would. But they got so many puppets out there, you shouldn't believe anything you hear now a days.

By the way KOB we don't allow live trip reports here, it gets really messy and besides trip reports belong in the appropriate forum. It's nice to see a report up though, maybe you could have a quick proofread, see if it's how you want it to be, choose an appropriate title and I could send it over to Trip Reports, and post a link to the report back here once it's moved?

I actually wrote it up already and posted it. I wasn't aware of that. I don't think it got deleted? Although most of it was written sober, I was just posting it live as I Was coming up. I didnt get a chance to describe the actual rolling effects, until the next day. So, next time in the future I'll write up the trip report in the other section. I always thought the big and dandy threads was where I read all the reports from though? Oh well...lol
I don't suggest that 5-IT is deadly bar none, but is appears to have a low safety margin. Look at the reports of overdose in this thread. Extreme hyperthermia and confusion. Look at the documented deaths from methylone, MDMA, etc. Extreme hyperthermia and confusion. Notice anything? This is called acute serotonin toxicity

Ok that is the one effect I notice is worse with 5-IT compared to MDMA, is the overheating. But it's not extreme enough to be deadly..and I seriously doubt neurotoxic. Of course if you OD on something like that, I would not expect to survive it. But you are not disagreeing with this. You are saying that you think it could be neurotoxic because of this side effect? Or you are saying the side effect is because the drug is neurotoxic? I don't see any logic in that. Many things can cause you to get a fever or confusion as a side effect. It doesn't mean you're permanently damaging your brain. I've went into delirium from eating a massive overdose of shrooms...but it didn't cause any permanent damage, and it has been proven that you cannot overdose on P. Cubensis (Which is what I tested the limits with...after reading in a book that there is no OD level, I Went absolutely insane with them, ate over 50 fresh caps, and experienced a level 5 out of body experience trip)

So this is just an example that different drugs cause different effects. 5-IT doesn't cause delirium unless you OD, and if people did die, it would probably be from organ breakdown through overheating. 5-it works differently than MDMA does on the body. It is more like a combo of tripping and rolling. I would compare it slightly to a piperazine...but just a VERY enjoyable one with minimal side effects!Temp. levels dont rise TOO high with 5-IT, just enough to where you may get the chills at points, and your skin may feel hot. Also I've gotten a rash and some weird marks on my body since doing all this shit, but I think I may of just gotten abducted or something, as the marks are "Perfect Triangles"

Freaky shit, I dont even remember getting abducted at all...and I didn't sleep at all during these nights, so it must of happened when I Was awake. I did have somewhat missing time, but I thought that was just from the dope. According to the conspiracy theories I've been reading on the internet, they probably abducted me to preform some weird demonic sex magick ritual bullshit. Not cool at all... But then again no one ever said Satan was hip. I think if he just tried some good MDMA, he would want to go back with god. What does everyone here think?

Wait...sorry...that would be getting off topic.
 
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I just noticed a well respected vendor quit selling 5-IT out of the blue. No notice, not mentioning it on the website, nothing. Mabye there is something goining on with this chem after all ;)
 
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