Xorkoth
Bluelight Crew
In my experience, some people metabolize the 4-AcO esters into their 4-HO counterparts more efficiently than others, or that's my theory anyway. I think that the 4-AcO-tryptamines are able to cross the BBB, and they do have their own effects, but that they are also metabolized into the corresponding 4-HO-tryptamine. However some people's bodies are able to convert more or less of it, and if you can convert more, then the effects of the 4-AcO will be closer to or even virtually identical to the 4-HO. For myself, I have found differences between all of the pairs, some of them dramatic (for example, 4-AcO- vs 4-HO-DMT). I have tried both 4-HO-MET and 4-AcO-MET, but I've only done 4-AcO-MET once so I can't really say much about differences yet.