Hi all. I'm trying to create a guide for my crew and I before we dip our toes in the 25D waters, could you please give this a lookover and critique or point out anything I may have missed? Thanks a million. Love & Light. ~!hyper✰
What I've been able to extrapolate from this thread:
25D-NBOMe Guide
Dosage: 0.5 -2.0 mgs -- Liquid measure will be the most accurate way to measure this.
500ug - light
700ug-1.4mg common
1.5mg-2.0mg strong
25D-NBOMe is the NBOMe derrivative of 2c-D. Some trip reports anecdotally report 2c-D has nootropic effects, while Shulgin referred to 2c-D as "pharmacological tofu." It is unclear as of yet whether 25D will share these characteristics --ie. a tool for expediting learning &-or good/safe to combine with other things? Reports seem to characterize 25D-NBOMe, and NBOMe's in general, as having more psychedelic depth than compounds in the 2c-X series, with a mindscape more similar to the DOx series. For 25D: Reports of OEVs/CEVs, a sense of well being and calm, and a tendency for psychedelic ideation --does this mean egodeath? Nichols, the head of research who designed this series, is purported to have said the the NBOMe's aren't like classical psychedelics. It's unclear whether he means structurally, in terms of receptor activity, or subjectively. However, data on 25I-NBOMe suggest 5ht2a (serotonin) receptor activity. It's likely other NBOMe's would follow a similar pattern of receptor affinity.
Duration: 5-8 hours
Methods of Ingestion: Buccal (side of cheek), nasal, sublingual, IM, plugging.
~Oral ingestion, if it works, is less effective and requires higher dosing. At present, there isn't current data available on exact dosing strategy for this ROA. Intranasal and Buccal seem to be the best methods, with the intranasal route being slightly more potent. Also read some positive plugging experiences. Some have discussed the possibilities of delivering the NBOMe series in a nasal spray, but accurately titrating the dose-per-spray ratio could pose a problem. Also, have read this compound is hydrophobic. At current, it is unknown if the decreased oral potency is due to it's hydrophobicity, or whether it is the result of breakdown of NBOMes via enzymatic activity in the GI tract. Also, giving it's potential hydrophobic nature and given that I don't have the MSDS in front of me, I'm not sure of it's solubility, although a 1:3 ratio of ethanol to distilled H2O should work fine. 20 mgs diluted in a 20ml solution of everclear/dH2O. Sub milligram liquid dosing can be accurately done with an oral syringe which can be gotten for free at your local pharmacy and dripping 2mLs tops of liquid up yr snoz shouldn't too be much of a big deal.
Mentally, it's also quite mild. No strong mindfuck effects. You can be introspective, but in a very calm and accepting way. 
