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The Big & Dandy 25D-NBOMe (NBOMe-2C-D) Thread

What [b]in your experience[/b] would be a maximum responsible buccal dose for 25D?

  • up to 400 μg

    Votes: 1 3.4%

  • up to 600 μg

    Votes: 2 6.9%

  • up to 900 μg

    Votes: 8 27.6%

  • up to 1200 μg

    Votes: 8 27.6%

  • up to 1500 μg

    Votes: 2 6.9%

  • a dose higher than 1500 μg

    Votes: 8 27.6%
  • Total voters
    29
what type of surfactant did your friend use in the nasal spray? been thinking of going that route with some 25x-NBOMe's in the near future if i can find a reliable metered dose nasal sprayer. Also, about what is the max amount of fluid you've been able to insuffuse before drippage occurs? I'm thinking 0.25mL would probably be getting close to if not crossing the line.
 
A nasal spray sounds very good, I never really came around to experimenting with K in nasal spray and also only found nasal spray bottles that were completely sealed, never the other kind.
Also I guess that with a nasal spray there is a certain minimum amount to prepare to get the thing to function right, but other than that not really a threshold or different reason not to do that. Should work fine, probably even without the surfactant.

If we are talking surfactants I assume it is lecithin and things like that, not SDS or anything? Just checking, I should assume it is a safe type.
 
Surfactant used was always around 1weight-% Tween80 (Polysorbat 80) in pure H2O. The nasal sprays are aviable online or at drugstores to make a e.g. NaCl-spray. One shot with this sprayer was ≈0.13ml which was acceptable for up to 5 shots, afterwards the soapy smell and taste of the tenside got a little disturbing. Concentration depends on estimated dosage-steps.
An exact formula for dosing the surfactant is not known to me, but with 1% the solution might be saturated with 3-4mg/ml (25C)....
 
Actually I was unaware that surfactants were effective in the nose although there is even more reason for it there than in the mouth. I noticed when it was mentioned in the 25C thread. I think I then said as well that it reminds me of nano delivery systems, pretty interesting phenomenon for sure until you are mistaken and significantly overdose. I think I'd experiment with it myself but only after ensuring the procedures were identical each time before I would step up the dose, of course starting extra low.
A friend of mine tells me that pure DXM is not really very effective for him unless it is taken with a surfactant (PEGylation), and that a surfactant works better after having left to stand overnight. The change in result for him (I do not know the factor) would indicate that there is something to gain, how much depends on the general membrane transfer properties of the compound. I don't think you would win a whole lot with LSD for example.
Conversely someone might say: who was the genius that decided NBOMe compounds were not potent enough on their own. ;)
 
I understand your point.
In the beginning it was just the idea to avoid waste of substance due to all the negative reports on administration of NBOMes.
The hypothesis was that with a lipophilic compound (25D maybe more than 25C) which acts as a highly-selective serotonin agonist, it might be very advantageous to emulsify it, make it more hydrophilic, so it can be better transported through the membrane into the blood-stream and through the BBB.
Nasally ROA was chosen because of the "short way" to the corresponding receptors, based on not knowing the mechanism or enzyme which makes it orally inactive and the fact that it might be an enzyme which already starts work in the mouth (might have been naive to some extent, but the result was always good). ;)
Another point was that with the tenside Tween80 out of a sprayer it forms a foam in the nose which will not run down your throat that fast and stays long enough at the membrane.

Finally the good results prevented researching other ROAs as it takes a lot of time to debar tolerance-issues, and research on the compounds action with one same (working) road was more interesting at the moment... =D

And of course they are extremely potent on their own, but as we know it is not that easy to bring them where they act that potent... :\
 
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Sure, yeah. :)

Don't forget to report back after your experiments, the details can be helpful for others as well!
 
Hmm, I am still not sure what dose we should start with. 800 ug blotters sound like a good starting dose, but I really hate underdosing with psychedelics. It just leaves me in the strange state where I am definitely off baseline, but I don't feel like I "broke through".

Maybe 1200 ug would be a better idea. I guess I need to read the 25C-NBOMe thread in more detail.
 
herbata_yanga said:
If you want to use buccal ROA then I'll suggest you to take 1.5-2 mg
Click to expand...

Yeah we are using buccal ROA. How would you compare 1.2 mg in terms of LSD? Would that be like doing 200 ug of LSD? I know that you can't compare two different substances and so on, but I am just asking for a rough estimate.

Everyone who will be dropping has experiences with psychedelics/entactogens, so we definitely want to trip relatively hard, but at the same time I like to be cautious with new substances.
 
levictus,

I've tried 25D two times and LSD one time.

~200 ug LSD for me was deeper and more powerful than 2 mg of 25D :P

If you want to trip hard then don't bother dosing below 2 mg.
 
levictus said:
How would you compare 1.2 mg in terms of LSD? Would that be like doing 200 ug of LSD?
Click to expand...

Mentally they are 2 different worlds and you can't have as deep as LSD trip no matter how much 25D you would take. Comparing visual aspects only for me 2mg 25d was maybe on the level of 80-90ug LSD.
 
kurwa sami Polacy? : D

@FULLofSTARS

Yeah I can agree that 25D-NBOMe, when you speak about mental effects, has 0 potential to equal profound and deep mind alteration that LSD can produce. But as for visual effects, 2 mg was weaker than 200ug LSD - but not that weaker.

edit: I was not precise - despite the fact that LSD is deeper, 25D is still great psychedelic for me and can produce epic experiences, they are just minutes of deepest spiritual mindfuck, not hours
 
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FULLofSTARS said:
Mentally they are 2 different worlds and you can't have as deep as LSD trip no matter how much 25D you would take. Comparing visual aspects only for me 2mg 25d was maybe on the level of 80-90ug LSD.
Click to expand...

That's a lot of horse shit TBH, different psychedelics produce different mental states for different people and it really gets on my nerves when people put LSD on a pedestal as the "ultimate" psychedelic mind state or something, come on that is completely ridiculous. I've taken high doses of LSD and low doses various times and have never had particularly interesting mental insights whereas on 2c-e or mushrooms and even DOC I've made true insights. These things vary from people to people and I don't doubt that 25D could give someone a more interesting experience than LSD... just not for you.
 
Yeah, 25d is physically very enjoyable and capable of giving intriguing visual effects at higher doses but i am all against comparing it to LSD because it just doesn't have that "life changing", ego-shattering, mystical potential that acid has.

edit @IamMe90

I wrote that because when the substance became popular there was a hype that 25D was "a lot like LSD" and then a lot of people that tried it were dissapointed because they expected something else than they got. A lot of substances can give deep mental effects, weed for example but it doesn't mean that you can say that weed is comparable to LSD.
 
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FULLofSTARS said:
Yeah, 25d is physically very enjoyable and capable of giving intriguing visual effects at higher doses but i am all against comparing it to LSD because it just doesn't have that "life changing", ego-shattering, mystical potential that acid has.

edit @IamMe90

I wrote that because when the substance became popular there was a hype that 25D was "a lot like LSD" and then a lot of people that tried it were dissapointed because they expected something else than they got. A lot of substances can give deep mental effects, weed for example but it doesn't mean that you can say that weed is comparable to LSD.
Click to expand...

Makes sense, I didn't realize 25D had been compared to LSD specifically, only saw that with 25c although I haven't really been following this thread too carefully haha
 
I gave this a go last Monday. I decided to start small and cut an 800ug blotter in half and placed one half on my gum and gave the other to a friend who did the same. A metallic taste was noticed, and my friend became sick of it after 15 minutes or so and removed the blotter. I kept it in for 25 minutes before doing the same. The effects were expected to be mild, but to be honest, I hardly felt anything.

Both me and the friend said it was a feeling akin to smoking really nice hash - Stoned, but not sluggish. This persisted for a couple of hours. Very slight visuals were noticed if I was to stare at something and zone out a bit, similar to coming up on mushrooms ("Is that moving or did I imagine it?"). This didn't last long. It should be noted that I had been smoking some weed both before and throughout the experience, as well as consuming beer (although not fast enough to get drunk).

Overall I was disappointed after hearing many good things about this substance, even at lesser doses. I plan to do it again this coming Monday, but with a whole blotter (I also plan to leave it in for longer, that taste really isn't nice though, especially when you can't swallow). I'll be smoking less this time as well, it's a possibility that the weed clouded the experience somewhat.
 
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