Davevanza
Bluelighter
- Joined
- Apr 24, 2011
- Messages
- 90
A high Benzos dose
"Originally Posted by ThHardMotherfucker
Yeah same, agree with pinkanga...There was no HR value in that other thread.
I'm currently scripted 6 mg Clonazepam/4 mg Alprazolam daily"
In Australia, Clonazepam ( under the brand only 2 of them, Rivotril and Paxam), is used only for an anticonvulsant.
With your use of 6mg of Clonazepam, if you are here in Australia, the Doc must have prescribed it for Epilepsy.
( But in States, it's a diffetent case. Clonazepam is used for Panic Disorder, and the dose ...... well it depends on the severity of your symptom and how many mg your Doc is going to give you. But not here, in Australia. it's a different case.) The MIMS book only states that it's for anticonvulsant. But, off-label, the Doc could give it for Panic Disorder. But the problem is, out of 50 Doctors.......I would say, only 2 or 3 of them that know Clonazepam is used for Panic Disorder like Alprazolam. It's a sad thing...
As with 4mg Alprazolam, it is still within therapeutic dose " only for Panic Disorder" here in Australia.
The Max dose is 10mg/day for it.
But, seldom, any Doctors, would prescribe beyond 2-3mg of Xanax ( Alprazolam) daily, even it's stated could be up to 10mg for Panic Disorder.
The most, the are comfortable to write a prescription of Alprazolam, 1mg t.i.d. ( 1mg 3x/day). TOTAL 3mg
( but it depends on the severity of your symptom too, and the Doctor too. He may prescribe 2mg b.i.d ( 2mg 2x/day) .. TOTAL 4mg
"I take 2 mg Clonazepam, after my Omeprazole, with either another 2 mg of Clonazepam or 2 mg Alprazolam for a severe debilitating anxiety disorder."
Well, Seldom, one doctor would prescribe 2 different benzoz. You may be an exception, for a reason by the doctor.
Omeprazole is a Proton Pump Inhibitor. It actually is a newer medication after Zantac ( Ranitidine) and Cimetidine ( which has lots of interactions if you read in MIMS ANNUAL.
The advantage of Omeprazole, like Ranitidine, they both inhibit acid secretion to the stomach. ( To treat stomach ulcers, etc)., but, Omeprazole also forms a sort of " coating to the stomach lining", and that's why, when you take NSAIDs ( Ibuprofen, Naproxen, Diclofenac, Piroxicam, etc) you don't get "stomach bleeding".
"Omeprazole does wonders at giving your benzodiazepine of choice, a boost. I highly recommend it. Plus, it's added benefit includes the reduce risks associated with NSAID use, such as peptic ulcers, a few people who might read this, this applies to you Panafen + people...
"
This actually RAISE A QUESTION TO ME.
So Proton Pump Inhibitors ( Omeprazole, Lansoprazole, etc) could give a boost to Benzodiazepines.
Well, yes I know Panafen. It's an OTC meds ( Only Ibuprofen 200 + Codeine 12.8mg ) comes in 15 or 30 tabs boxes.
OK. BACK TO BENZOS.
This is an interesting thing if Omeprazole amplifies the use of Benzos.
All I know, Luvox ( Fluvoxamine), an SSRI antidepressant, when combine with a Triazolo-Benzodiazepines like Alprazolam, Triazolam ( Halcion, a Hypnotic) and Midazolam ( Available only via injection in hospital use), could double up the amount of those Triazolo-Benzos, like Alprazolam.
In other words, You take Fluvoxamine and Alprazolam, you only need a small dose of Alprazolam, as the effect in your body "feels" as if you are taking double the dose. ( This works via CYP4503A4. Fluvoxamine is an inhibitor of that iso-enzyme. Alprazolam is the substrate. So by inhibiting it, there are more of the Alpha-hydroxy-alprazolam in the plasma. This will result more of the predictable amount in plasma levels. so far, it doubles up.)
As with Serzone ( Nefazodone), an antidepresant, it could make 4x of the predictable amount of Alprazolam in the blood plasma levels.
( But Serzone is taken off the market bcoz of hepatotoxicity it induced).
"Starting tomorrow though, I'm going to limit my benzodiazepine use to 2 mg Clonazepam. I've been on it for a month, time to taper off it, started off using it as an augmentation therapy until the Zoloft 100 mg kicked in. I don't know though, I feel as if the Zoloft is making me more anxious, rather than my previous Rx'd antidepressant, Paroxetine 40 mg."
IN MY EXPERIENCE, YES, ZOLOFT, made me more anxious. I don't know why. ( I read a book, it's a Testimony, of , well, mainly Zoloft then other SSRIs, ruins life.)
The title of the book in the Library is : DYING FOR A CURE . by Rebekah Beddoe
Even 25mg of Zoloft ( Sertraline) caused akathisia to me.
( Prozac, they say is activating, Aropax/Paxil they say is rather sedating. I don't like actually TO USE THE WORD,"Activating", as it is not a stimulant, but rather, it causes akathisia or inability to sit still, or relax, so someone taking it must move around, and I would say, it's a torture like experience rather than a nice one. It's like taking an antipsychotic
- )
Maybe you should stick to Paroxetine if it helps you.
just remember, everyone reacts differently even to the same medication, coz our bodies' way of metabolizing it. ( Some has more CYP2D6, some don't.)
"Originally Posted by ThHardMotherfucker
Yeah same, agree with pinkanga...There was no HR value in that other thread.
I'm currently scripted 6 mg Clonazepam/4 mg Alprazolam daily"
In Australia, Clonazepam ( under the brand only 2 of them, Rivotril and Paxam), is used only for an anticonvulsant.
With your use of 6mg of Clonazepam, if you are here in Australia, the Doc must have prescribed it for Epilepsy.
( But in States, it's a diffetent case. Clonazepam is used for Panic Disorder, and the dose ...... well it depends on the severity of your symptom and how many mg your Doc is going to give you. But not here, in Australia. it's a different case.) The MIMS book only states that it's for anticonvulsant. But, off-label, the Doc could give it for Panic Disorder. But the problem is, out of 50 Doctors.......I would say, only 2 or 3 of them that know Clonazepam is used for Panic Disorder like Alprazolam. It's a sad thing...
As with 4mg Alprazolam, it is still within therapeutic dose " only for Panic Disorder" here in Australia.
The Max dose is 10mg/day for it.
But, seldom, any Doctors, would prescribe beyond 2-3mg of Xanax ( Alprazolam) daily, even it's stated could be up to 10mg for Panic Disorder.
The most, the are comfortable to write a prescription of Alprazolam, 1mg t.i.d. ( 1mg 3x/day). TOTAL 3mg
( but it depends on the severity of your symptom too, and the Doctor too. He may prescribe 2mg b.i.d ( 2mg 2x/day) .. TOTAL 4mg
"I take 2 mg Clonazepam, after my Omeprazole, with either another 2 mg of Clonazepam or 2 mg Alprazolam for a severe debilitating anxiety disorder."
Well, Seldom, one doctor would prescribe 2 different benzoz. You may be an exception, for a reason by the doctor.
Omeprazole is a Proton Pump Inhibitor. It actually is a newer medication after Zantac ( Ranitidine) and Cimetidine ( which has lots of interactions if you read in MIMS ANNUAL.
The advantage of Omeprazole, like Ranitidine, they both inhibit acid secretion to the stomach. ( To treat stomach ulcers, etc)., but, Omeprazole also forms a sort of " coating to the stomach lining", and that's why, when you take NSAIDs ( Ibuprofen, Naproxen, Diclofenac, Piroxicam, etc) you don't get "stomach bleeding".
"Omeprazole does wonders at giving your benzodiazepine of choice, a boost. I highly recommend it. Plus, it's added benefit includes the reduce risks associated with NSAID use, such as peptic ulcers, a few people who might read this, this applies to you Panafen + people...
"
This actually RAISE A QUESTION TO ME.
So Proton Pump Inhibitors ( Omeprazole, Lansoprazole, etc) could give a boost to Benzodiazepines.
Well, yes I know Panafen. It's an OTC meds ( Only Ibuprofen 200 + Codeine 12.8mg ) comes in 15 or 30 tabs boxes.
OK. BACK TO BENZOS.
This is an interesting thing if Omeprazole amplifies the use of Benzos.
All I know, Luvox ( Fluvoxamine), an SSRI antidepressant, when combine with a Triazolo-Benzodiazepines like Alprazolam, Triazolam ( Halcion, a Hypnotic) and Midazolam ( Available only via injection in hospital use), could double up the amount of those Triazolo-Benzos, like Alprazolam.
In other words, You take Fluvoxamine and Alprazolam, you only need a small dose of Alprazolam, as the effect in your body "feels" as if you are taking double the dose. ( This works via CYP4503A4. Fluvoxamine is an inhibitor of that iso-enzyme. Alprazolam is the substrate. So by inhibiting it, there are more of the Alpha-hydroxy-alprazolam in the plasma. This will result more of the predictable amount in plasma levels. so far, it doubles up.)
As with Serzone ( Nefazodone), an antidepresant, it could make 4x of the predictable amount of Alprazolam in the blood plasma levels.
( But Serzone is taken off the market bcoz of hepatotoxicity it induced).
"Starting tomorrow though, I'm going to limit my benzodiazepine use to 2 mg Clonazepam. I've been on it for a month, time to taper off it, started off using it as an augmentation therapy until the Zoloft 100 mg kicked in. I don't know though, I feel as if the Zoloft is making me more anxious, rather than my previous Rx'd antidepressant, Paroxetine 40 mg."
IN MY EXPERIENCE, YES, ZOLOFT, made me more anxious. I don't know why. ( I read a book, it's a Testimony, of , well, mainly Zoloft then other SSRIs, ruins life.)
The title of the book in the Library is : DYING FOR A CURE . by Rebekah Beddoe
Even 25mg of Zoloft ( Sertraline) caused akathisia to me.
( Prozac, they say is activating, Aropax/Paxil they say is rather sedating. I don't like actually TO USE THE WORD,"Activating", as it is not a stimulant, but rather, it causes akathisia or inability to sit still, or relax, so someone taking it must move around, and I would say, it's a torture like experience rather than a nice one. It's like taking an antipsychotic
- )Maybe you should stick to Paroxetine if it helps you.
just remember, everyone reacts differently even to the same medication, coz our bodies' way of metabolizing it. ( Some has more CYP2D6, some don't.)
