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Post a chemical that you think has some serious potential to become a winner in the RC market

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TMA-6-NBOH
 
I don't think the alpha methyl is needed. The N-benzyl moiety prevents metabolism of the stuff. You CAN add it, but I bet duration is very long. The phenolic moiety overlays the =O of the amide in LSD. I think the N-substituents are just space-filling.... which the benzene ring does perfectly.
 
simstim said:
TMA-6-NBOH
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I always thought that the serotonergic N-benzyl pea‘s only work without an alpha alkyl group. As far as I know things like doc-nbome or tma6-nboh don’t Show activity. I think it is discussed in heims thesis already.
 
There was someone on some german drug Forum some years ago posting a rather big pdf with new peas mainly of which he manufactured almost all himself. I don’t have this file anymore but it might be possible that I’ve seen him here on bluelight, too. All I remember is that he tried the 3-thienyl mpa analog (which has been made by German authorities when mpa was sold by the ton) and, more interesting, many psychedelic pea‘s with a N-propyl-3-diethylamido (hope this is Right) rest, inspired by the lsd backbone. Some of these seemed to be pretty potent. Would be nice to get ones hands at least onto this pdf again. The username was some German first name iirc.
 
Faust66 said:
please be more careful as to not drop anymore keywords, someone might find out whatever the fuck you're talking about.
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How about you cool off on the posting and do a bit more reading.

You can't listen if you're talking all the time
 
I think this has some serious development potential for the future.

APBTs surely have at least as much profit potential as the lower quality cathinones they try and pass off year after year.

APBT's - The next generation of psychedelic/entactogenic/empathogenic amphetamines is coming!!! Bring on the benzothiophenes!

https://www.nature.com/articles/s41386-021-01221-0 According to this article benzothiophene based "amphetamines" are more potent releasers of serotonin than their benzofuranyl analogs. They also have a higher affinity for the 5-ht-2 receptors and cause rats to develop the stereotype head twitch...
bluelight.org bluelight.org
 
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I would put money on this one

Amphetamine SAR study shows beta ketone reduces maoi activity and the n-methyl prevents the formation of a dimer

Ketamine salts solubility

Yes - The LogP is one of Lipinski's Rules of Five. -No more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds) -No more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms) -A molecular mass less than 500 daltons -A calculated...
bluelight.org bluelight.org
 
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izo said:
I always thought that the serotonergic N-benzyl pea‘s only work without an alpha alkyl group. As far as I know things like doc-nbome or tma6-nboh don’t Show activity. I think it is discussed in heims thesis already.
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I thought they were only reduced or equivalent in potency I didn't know that they were inactive.

So you have a link to this thesis.
 
simstim said:
I would put money on this one

Amphetamine SAR study shows beta ketone obliterates maoi activity and the n-methyl prevents the formation of a dimer

Ketamine salts solubility

Yes - The LogP is one of Lipinski's Rules of Five. -No more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds) -No more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms) -A molecular mass less than 500 daltons -A calculated...
bluelight.org bluelight.org
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It does? Always thought keto gtoups just bypassed the effects of a beta hydroxy group (far too much adrenergic activity), but the alpha methyl conferred competetive MAOI activity, by not allowing MAO to take active conformation. I mean ephedrine has very weak, competetive MAOI activity, courtesy of alpha methyl group. If the keto group abolished MAOI activity, methylone would just have alphamethyldopamine metabolite with no entactogen activity.
 
fastandbulbous said:
It does? Always thought keto gtoups just bypassed the effects of a beta hydroxy group (far too much adrenergic activity), but the alpha methyl conferred competetive MAOI activity, by not allowing MAO to take active conformation. I mean ephedrine has very weak, competetive MAOI activity, courtesy of alpha methyl group. If the keto group abolished MAOI activity, methylone would just have alphamethyldopamine metabolite with no entactogen activity.
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It doesn't completely abolish it but some of the beta ketones in the study were weaker maoi's than plain old amphetamine.

Beta methoxy too!
 
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God i have discovered this post a min ago, it will be the paradise to read it all, i used at least 10 differend RCs high quality when they was available like more than 10 years ago, the one i liked more was methoxetamine, but i had grams of that sht, i was gifting it or trading for other drugs, and injecting 25mg. aprox intramuscular 1 or 2 times and idk how 5 grams ended, most gifted, the most potent tryptamine was a-MT SO far, specially in the weight dose, i smoked and taken orally, bot had very long half life IME, and had a strong serotoninergic stimulant effect, one time was amazing becouse i was in piano classes and i will was about not to go cuz i was a-MTed heavy after oral and smoked doses, but the experience was amazing, it puts me anxious that the guy that gives my class, got the violoncello and started to follow me playing, i deeply feel how that helped me to continue playing like a guide, and returning to home, i was inmediatly puting Debussy and in the bed with a gf loving the music and all the calm atmosphere in the moment, a really unique psychodelic related experience, specially becouse the speedy effect that provocates on me, but the serotoninergic easily attenuated it.
I have trip reports but are wrote in other forum before i know about blight :c
 
@fastandbulbous

I feel mxe is good as its designed, idk if will losse some half ilfe, get more dopaminergic / NAergic, maybe even opposite, i think MXE have a high potential of a very good antidepressant, i onlyu have experience with IM and sniffed doses, mostly IM, never got a "K hole", never near in one, and have done tons of K too, and just one time in the hole, wasnt so bad and i even got asleep few hrs, but i feel MXE different specially if you try to go to higher doses, and low doses are superb antidepressant effects, do you felt that effects too?
 
Fourofakind said:
@fastandbulbous

I feel mxe is good as its designed, idk if will losse some half ilfe, get more dopaminergic / NAergic, maybe even opposite, i think MXE have a high potential of a very good antidepressant, i onlyu have experience with IM and sniffed doses, mostly IM, never got a "K hole", never near in one, and have done tons of K too, and just one time in the hole, wasnt so bad and i even got asleep few hrs, but i feel MXE different specially if you try to go to higher doses, and low doses are superb antidepressant effects, do you felt that effects too?
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Shouldn't be that different, as the exe is mainly metabolized via N-dealkylation (cytochrome CYP3A4), same as mxe. Maybe the serotonogic activity will be a bit different, but I will be gobsmacked if it's wildly different.
 
fastandbulbous said:
Shouldn't be that different, as the exe is mainly metabolized via N-dealkylation (cytochrome CYP3A4), same as mxe. Maybe the serotonogic activity will be a bit different, but I will be gobsmacked if it's wildly different.
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No -it's O-dealkylated. Different enzyme system.

I'm also wondering if you checked the parent I found on the 2-Cl-5-MeO derivative of K. I keep asking why someone would devote and entire patent to 1 compound. If nothing else, it suggests that the ortho & meta substitutions are not next to each other so IF hitting both has some huge benefit, isn't it worth considering?

I would have thought it expands knowledge of the QSAR? BUT I freely admit, you know a lot more than me.

I don't say diphenidine was great, but it could have been explored... and diphenidine was HUGE because of UK ban on arylcyclohexylamines...

So that was the only class I KNEW worked.

Pity isophenidine was never made in bulk (for political reasons) because it really is very nice. The first thing I found was than the 1,2-diphenylethylamine class of NMDA antagonists follow the PCP QSAR (for amines) rather than K. Ephenidine was rubbish.
 
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MMDA-2

Would love for this to be made available on the RC market i can see it becoming very popular. What ive read in PiHKAL about it makes it sound very nice and the dosage range is on point. Best of all its not scheduled in the states...
 
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