Post a chemical that you think has some serious potential to become a winner in the RC market

[simstim]

I'd say they belong to no one and/or all of us.
But I guess I understand your sentiment.

Are you saying that guy was lying about synthing an etorphine-level opioid from bupe? I mean he could have been, which is why I came to ask people more knowledgeable than me about chemistry topics.

It's amazing to think bupe could hold the potential to become a full agonist with some steps.

I was just curious is all. And enjoy learning, so no need for hostility.


I've read that mixing acetic anhydrous with almost any opiate/opioid changes it into another obscure opioid. Is this true/possible? And would acetic acid in vinegar be sufficient or are we talking needing lab grade equipment and chemicals?


Sorry for my ignorance.

It is true that esters of many opioids exist and are active. Heroin is the diacetyl ester of morphine. One of heroin's active metabolites is 6-monoacetylmorphine.

Heroin production is the biggest reason I know of why acetic anhydride is a watched precursor chemical.

It's possible to make an orally active opioid from loperamide by reacting it with acetic anhydride to form O-acetyl-loperamide but it may not be safe to take it. The only guy I know of who tried that ran a synthesis discussion forum. He died from a stroke. Whether it was related or not I do not know.

The guy claimed acetyl loperamide was similar to methadone in dosage and duration.

I would've tried it a longtime ago, but it's not terribly easy to get acetic anhydride. I've heard people suggest that it may be possible to substitute glacial acetic acid, but I have no clue as to whether anyone has done it.

 

[simstim]

not sure if the n-acyl thing works in everything, hopefully these would be prodrugs

Why not just add an n-hydroxyl group like adrafinil, FLEA, the HOT series, and MDOH? That should make it a prodrug.

That may make it hard on the liver though. That's why adrafinil got pulled.

 

[DeathIndustrial88]

It is true that esters of many opioids exist and are active. Heroin is the diacetyl ester of morphine. One of heroin's active metabolites is 6-monoacetylmorphine.

Heroin production is the biggest reason I know of why acetic anhydride is a watched precursor chemical.

It's possible to make an orally active opioid from loperamide by reacting it with acetic anhydride to form O-acetyl-loperamide but it may not be safe to take it. The only guy I know of who tried that ran a synthesis discussion forum. He died from a stroke. Whether it was related or not I do not know.

The guy claimed acetyl loperamide was similar to methadone in dosage and duration.

I would've tried it a longtime ago, but it's not terribly easy to get acetic anhydride. I've heard people suggest that it may be possible to substitute glacial acetic acid, but I have no clue as to whether anyone has done it.

Thanks for that info!!

So vinegar & it's tiny bit of acetic acid probably wouldn't change the molecule much eh?
How does one go about creating this reaction?

Forgive my ignorance if I sound stupid (I have almost no chemistry experience), but I have tried boiling buprenorphine & loperamide with vinegar/acetic acid.
I assume it takes more than just mixing and heating the substances together though. As the end result was mostly a gel-like substance at the bottom once all the water/vinegar evaporated. And I noticed nothing after ingestion, so I'm not sure it even did anything. lol

But I find it a fascinating subject either way.

 

[simstim]

Thanks for that info!!

So vinegar & it's tiny bit of acetic acid probably wouldn't change the molecule much eh?
How does one go about creating this reaction?

Forgive my ignorance if I sound stupid (I have almost no chemistry experience), but I have tried boiling buprenorphine & loperamide with vinegar/acetic acid.
I assume it takes more than just mixing and heating the substances together though. As the end result was mostly a gel-like substance at the bottom once all the water/vinegar evaporated. And I noticed nothing after ingestion, so I'm not sure it even did anything. lol

But I find it a fascinating subject either way.

It takes acetic anhydride + loperamide + heat.

If I were you I would suggest reading up on it first. Not only how to do the reaction, but about acetyl loperamide.

There are some concerns about it. Like whether or not it forms a metabolite which is similar to MPP+ or not. MPP+ causes parkinsonism.

 

[DeathIndustrial88]

It takes acetic anhydride + loperamide + heat.

If I were you I would suggest reading up on it first. Not only how to do the reaction, but about acetyl loperamide.

There are some concerns about it. Like whether or not it forms a metabolite which is similar to MPP+ or not. MPP+ causes parkinsonism.

When you say heat, do you mean like in hot water or actually heating up the compounds not suspended in liquid?

Hell, I guess if I had the ability to create acetyl-anything, I'd probably go with something like bupe, just to lower my chances of parkinsonism. Although I have done some sketchy experiments with lope while in desperation.


Would acetylbuprenorphine be a thing then? If it is, I don't think I achieved it when I boiled bupe with white vinegar. Probably cause it was acetic acid and not acetic anhydride. But it'd be interesting to try nonetheless.

I hate our arbitrary laws surrounding opioids & drugs in general. Opioids are the only thing that have ever saved my ass during severe depressive episodes (maybe stimulants too, but too many stimulants and i'm too busy being a sex fiend to be depressed, but then I get even more depressed right after). Buprenorphine use to help my depression but now it doesn't do jack shit for it really.

Feel free to shoot me a msg with some more info/links/advice! I don't wanna derail this thread too much but I appreciate the help from people more knowledgeable on this stuff than I am.


Hope everyone had a wonderful Christmas! Mine was spent detoxing & in withdrawal by accident. lol

 

[hardtack]

1-(6-methoxynaphthalen-2-yl)-2-pyrrolidin-1-ylpentan-1-one, 1-(6-methoxynaphthalen-2-yl)-2-pyrrolidin-1-ylhexan-1-one, their N-ethyl analogues, and arecoline based naphthalene substituted drugs like https://en.wikipedia.org/wiki/N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate, which is similarly just four simple reactions.

I don't get why mephedrone analogues are held in such a high regard, but I posted my opinion and explainations on this (and others "mystified" drugs like 4-MAR) here and elsewhere, more or less detailed.

People who buy mephedrone analogues do so, because they chase a lost memory.
That has not much at all to do with the real effects, but rather with nostalgia about the time they felt those effects.
Thats mephedrone-specific though.
Even the purest and cleanest mephedrone does not give any of those who miss "it" so much all the time, "this" back.
Its gone.
And the purity of the drug does not change or even influence this result much.

Thats like chasing the magic of MDMA by taking more and more MDMA, whenever you can get your hands on.
A not very smart move, that is.

Do not waste your time with this waste of time and fried brain cells.
Mephedrone might be nice for many at first, especially in excessive amounts, but everything is nice the first five times, even while it is actually frying your brain.... frying your brain barely ever feels bad for the person being fried.

One thing that needs to be more concentrated on: ß-naphthyl analouges of known stimulants.
Not alpha- though, those are much less active, up to just a tenth of the beta analogues.
6-MeO as said, are worthwhile.
Unsubstituted ones likely fall under analogues laws whereever you are.

Got to always reload as I call it.....taking the right supplements ie Aminos and takes time for body to replenish...if not you feel constantly tired. Been there many times. Mephedrone is just too much like Meth and more of stimulant , like the empathy and many RCs just work different for everyone. 4 MEC is mild balance and not overdoing it . Just my opinion, though?

 

[Anonymous Dissident]

(5-ethyl-4,7-dimethoxy-2,3-dihydro-1H-inden-1-yl)methanamine. It hasn't been synthesized to my knowledge. It may not be super potent, but I'd do a lot to get my hands on a sample. It's the ethyl analog of 2c-b-ind if you can't tell without the picture I can't get to load.

 

[simstim]

Alpha methyl beta keto fentanyl

Based on alpha methyl fentanyl and beta hydroxy fentanyl

Might produce the active metabolite alpha methyl beta hydroxy fentanyl

 

[OpiateKiller]

About to try 3-MMC.

I love amphetamines and have never tried the cathinone RC's... I'm excited to say the least

That and some bromazolam to come down with..

 

[simstim]

About to try 3-MMC.

I love amphetamines and have never tried the cathinone RC's... I'm excited to say the least

That and some bromazolam to come down with..

I would be excited too. 3-mmc is the shit. Much more MDMA like than amphetamine like. I hope you enjoy. I just ordered a gram of 3-mmc. Unfortunately the price per gram has doubled recently. Recently kilos were 3200 eur

 

[Tryptamite]

To acetlyate an opiate you need the anhydride and a short reflux or 99% (glacial) acetic acid and a reflux (boil) for a few hours. This is when applied to morphine or refined opium extract (black tar h or polish/eastern block kompot heroin or even new Zealand homebake h)

Not sure how it applies to other opiates. Acetyl chloride can also be used.

It's acylation really. Propionly anhydride will produce dipropylmorphine which the late Great limpet chicken was so fond ofi

m sorry if I've gone too far into chemistry. I know kompot threads exist hence my discussion of acylation. Please edit if I have broken any rules.

 

[Tryptamite]

I would like to see more oxazoline (aminorex) or phenmetrazine analogues being explored.

Phenetrazine might be interesting. Can't remember which one fastandbulbous said was the most euphoric.

 

[Tryptamite]

Alpha methyl beta keto fentanyl

Based on alpha methyl fentanyl and beta hydroxy fentanyl

Should produce the active metabolite alpha methyl beta hydroxy fentanyl

That has the cathinone structure in it perfectly!!

 

[xxsicknessxx]

I would still to this day do anything to try mdpv again to see if it's like I recall.

I used order this stuff as my main drug I used. I did bath salts way before meth (sober 2 years) but I would give it all up to do it once more.

Maybe that's drug addiction for you.

At one time I was in a position of having a .45 cal hand gun running around no sleep for a few days high as fuck then withdrawal would hit me ... Lucky I didn't shoot anyone.

Maybe.. maybe I wouldn't do it again. But still the mental idea that it would be worth it is in my head. Good thing USA banned it.


Gotta go visit China beer they still got it there..

 

[DeathIndustrial88]

To acetlyate an opiate you need the anhydride and a short reflux or 99% (glacial) acetic acid and a reflux (boil) for a few hours. This is when applied to morphine or refined opium extract (black tar h or polish/eastern block kompot heroin or even new Zealand homebake h)

Not sure how it applies to other opiates. Acetyl chloride can also be used.

It's acylation really. Propionly anhydride will produce dipropylmorphine which the late Great limpet chicken was so fond ofi

m sorry if I've gone too far into chemistry. I know kompot threads exist hence my discussion of acylation. Please edit if I have broken any rules.

So kitchen chemistry with distilled vinegar probably isn't worth it then huh? lol

 

[Faust66]

To acetlyate an opiate you need the anhydride and a short reflux or 99% (glacial) acetic acid and a reflux (boil) for a few hours. This is when applied to morphine or refined opium extract (black tar h or polish/eastern block kompot heroin or even new Zealand homebake h)

Not sure how it applies to other opiates. Acetyl chloride can also be used.

It's acylation really. Propionly anhydride will produce dipropylmorphine which the late Great limpet chicken was so fond ofi

m sorry if I've gone too far into chemistry. I know kompot threads exist hence my discussion of acylation. Please edit if I have broken any rules.

please be more careful as to not drop anymore keywords, someone might find out whatever the fuck you're talking about.

 

[Faust66]

So kitchen chemistry with distilled vinegar probably isn't worth it then huh? lol

distilled vinegar? ever heard of amazon? 20$ a liter of GAA

 

[Faust66]

I would still to this day do anything to try mdpv again to see if it's like I recall.

I used order this stuff as my main drug I used. I did bath salts way before meth (sober 2 years) but I would give it all up to do it once more.

Maybe that's drug addiction for you.

At one time I was in a position of having a .45 cal hand gun running around no sleep for a few days high as fuck then withdrawal would hit me ... Lucky I didn't shoot anyone.

Maybe.. maybe I wouldn't do it again. But still the mental idea that it would be worth it is in my head. Good thing USA banned it.


Gotta go visit China beer they still got it there..

yeah go visit China for a piece of shit drug and end up in jail for life, that's what they do to foreigners.

 

[DeathIndustrial88]

distilled vinegar? ever heard of amazon? 20$ a liter of GAA

You're worried some one might figure out what Tryptamite is talking about, then recommend to me where to find Glacial Acetic Anhydrous? lol

Isn't it a "watched" chemical in the US? It does show up for sale when you google it tho. Although not from amazon, but from industrial chemical companies.

Not to mention I wouldn't know what to do with it next anyway. Mix an opioid into it and cook it? No clue.

I'm a novice anyway, but if anyone actually does know a way to convert buprenorphine into something better, I will reward you. lol (kidding... or am I?)

Couldn't you acetylate any opioid really? Why isn't this a more common thing that people aren't doing then? If you can easily buy GAA online, you'd think there'd be more people doing so and turning their opioids into something stronger.

 

[Faust66]

You're worried some one might figure out what Tryptamite is talking about, then recommend to me where to find Glacial Acetic Anhydrous? lol

Isn't it a "watched" chemical in the US? It does show up for sale when you google it tho. Although not from amazon, but from industrial chemical companies.

Not to mention I wouldn't know what to do with it next anyway. Mix an opioid into it and cook it? No clue.

I'm a novice anyway, but if anyone actually does know a way to convert buprenorphine into something better, I will reward you. lol (kidding... or am I?)

Couldn't you acetylate any opioid really? Why isn't this a more common thing that people aren't doing then? If you can easily buy GAA online, you'd think there'd be more people doing so and turning their opioids into something stronger.

i was just being facetious sorry. yeah you would think more people would do it, but the knowledge of the process isn't talked about virtually anywhere, probably a good thing to keep the shithead DEA nose out of it. they don't watch the acetic acid. just the anhydrous.