Yeah, maintaining a regime is important. Microdosing psilocybin really tapped into something extremely powerful for me personally. More level-headed, less angry, improved problem-solving, improved stress response, drastically improved reaction time and motor skills, memory, increased risk taking (for better or worse), 0 depression for nearly 6 months. It was completely wild.
Fadiman's timing protocol was more effective for me vs Stamets'. Tolerance *did* matter. Stamets' regime could seem more effective in the short term but the slight tolerance build-up over the course of a week would reduce efficacy. Also, fully tripping on mushrooms, LSD, or anything with cross-tolerance would set efficacy back 1-3 weeks.
Being generally healthy made a huge difference - no alcohol, minimal caffeine, being super mindful of the usual big obvious nutrient deficiencies and balance (D, magnesium, Bs), generally good diet, generally good sleep.
What finally diminished the returns was, honestly, re-introducing dissos back in to my regular drug diet in increasing frequency, then the whole thing started to unravel.