Some of the compounds referred to could be/ have been used recreationally. The para substituted amphetamines are noted as often being chronically or acutely toxic. Fenfluramine causes damage to the heart valve and chordae tendinae as do quite a few other 5HT2B agonists. Via the same mechanism, in-vivo decarboxylated 5HTP is also a likely candidate - but that's been discussed elsewhere on this board.
I was also making reference to the methods used in the preparation of drugs; synthetic routes that employ toxic compounds or produce toxic intermediates or side reaction products. Many of these compounds are hepatic or renal toxins whereby chronic or sometimes a single exposure can result in organ disease. Heavy metal contaminants are also a major concern as these can be used as catalysts, or to prepare metal-organo intermediates.
Illicit drugs therefore are also a concern. For example, if safrole is an impurity in the precursor MDP2P, when reductive amination is performed, dihydrosafrole will be produced, which, if consumed is metabolised by liver isozymes into a powerful toxin. While the contaminate
should be removed via purification, dihydrosafrole is frequently mentioned in forensics analytical papers as an MDMA impurity.
vector (mod in Advanced DD) began a thread looking at
n-nitroso and bad drug design
....for those out there interested in N-nitroso derivatives as a way of circumventing prohibition bear this in mind.
The main points in my previous posts are:
1) Companies and individuals are searching for legal derivatives, analogues etc as a means of getting around laws.
2) Unless a manufacturer or supplier can validate QC processes and list active ingredients, then no-one really knows what the toxic profile of these compounds may be or what additional unwanted compounds may be present.
Even some of the more respectable companies have had QC problems - which we would like to think would always result in a recall of the products - but with a company like the ones that produce the neo doves, there's very little on the web that says anything about the organisation (other than on their site). If these guys have been around since the mid 90's, where's their history? What research have they (or others) actually done on these products? How and where are the products manufactured and by whom? What's the background of the company directors and employees?
All we really know is that these guys have a range of unidentified products, and have managed to circumvent, cleverly avoid, or slip under the legislation in
some countries - but not others. Some would say this is cleaver, others might term it as simply an excuse to be secretive and non-disclosing. Remember, the costs of 'safer' pharmaceuticals comes from the development, clinical trials, and quality control of the product.
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
