This is purely subjective evidence. MDPV gives me terrible side effects. Heart pain, kidney pain, very long lasting insomnia and peripheral stimulation. MDMA has never done me any harm that is comparable to MDPV or Mephedrone. Amphetamine has never caused me a single painful physical side effect. Cocaine, same story.Personally I'd say one is better off not abusing any stimulant, but if I had to choose one to use in any capacity, it would NOT be MDPV. Probably would be amphetamine.
I recently tried intranasal MDPV for the first time, albeit at much higher doses than mentioned here (15-70mg) and I experienced a similar subjectively "toxic" body load, including chest, renal pain and general ache/pain. Interesting, the body load with D-MPH is rather low, while high doses of sustained cocaine abuse (particularly the base) can have paralyzing next-day aches and pain.
It feels like a dirty d,l-methylphenidate with a social element.....less centrally acting (or should I say, more peripherally active), however, it subjectively feels like it may be a very weak SERT substrate. Unlike D-MPH, MDPV has a weak but noticeable "empathogenic" qualities and very mild visual disturbances. I suppose this may suggest some weak affinity for the SERT, or perhaps some more complicated downstream SERT modulation via MPDV, by-products, and metabolites. Focalin lacks this quality and has doesn't a very weak, and virtually insignificant affinity for the SERT. MDPV might be a weak substrate. But, perhaps like in the case of L-MPH, perhaps an enantiomerically MDPV would lack some of the subjective physiological toxic properties......
I have concerns about the cardiopulmonary toxicity of this drug, and I don't like its relative instability-reactivity. And please do not vaporize this compound, sure it will "work", but the compound is rather fragile and you'll be smoking some rather nasty toxic by-products.
Overall all, my guess is that in respect to long term toxicity of MDPV (neuro and otherwise), it would crudely rank in between racemic methylphenidate and cocaine (ie, > racemic MPH and < of cocaine hcl)......
In any case, it is certainly without a doubt a toxin, to what degree......I personally don't want to find out........