• N&PD Moderators: Skorpio | someguyontheinternet

MDPV - So how dangerous is it?

THANK YOU for the reassurance! I'm ridiculously conservative with my doses of all drugs, and plan to start with literally a few grains (powder, whatever) of MDPV and work my way up just to be safe.

I'm seeing a lot of reports of auditory hallucinations. Is that caused by large doses and sleep deprivation or is it inherent in the compound itself?
Many/most of those reports may have been mine (chuckling)... could be due to being on an SNRI antidepressant, as I haven't seen anyone else report anything near what I've gotten (fwiw, it has been with sleep deprivation/binging involved, never right away). Since using it and being on Effexor XR, I've gotten weird perceptual distortions at high doses that I've never gotten before, particularly w/sleep deprivation mixed in... but not at a one-off/normal dose.
 
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Wow so much hate for this drug. Unlike most people on here I think this is an amazing stimulant. Great combination of the right duration, increased motivation and increased productivity. I have never had the urge to redose unlike coke, meph, meth or methylone.
Over 3 years I have used about 750mg - never more than 5mg per dose and never redosed more than once per day. I never used it solely for getting high - it has always been for improved productivity and motivation. For that purpose it is perfect.
This drug is dramatically potentiated and improved by piracetam + choline for me. Euphoria is significantly more and duration is lengthed by a factor of 3 (~9hrs from 3hrs). Physiological sides like palpitations are also reduced significantly. Also, I can get back to a similar state by dosing piracetam alone for a couple of days. What is the mechanism for this? Is it safe(r) than MDPV alone? I have noticed that piracetam potentiates other stims including modafinil but not quiet as beautifully as it does for MDPV.
 
I gave this stuff a thorough review, consuming it intranasal every day at around 10-20mg per dose, up to 6 times a day for 10 days. I have the pure product, although i did buy the" white rush" bath salt to compare. According to my melting point apparatus, the white rush bath salt was in the mid 80% purity (not a substitute to HPLC or GC) which is pretty high for a mass produced compound. Subjectively it was similar to my 98% pure MDPV, with some minor differences.

In either case, i found this compound to be NOT a mere more potent methylphenidate. At higher doses, there is an an unmistakable 5-HT activity, with visual disturbances, empathy, and other properties no found in MPH. I tried oral doses as well, and found it fairly bioavailable. I tried to use it therapeutically, for my ADHD, and i found it therapeutically useless. The need for self administration is slightly stronger than intranasal d-MPH. The comedown is not particularly bad, and is not as" peaky" as inhaled d-MPH.

The drug, when abused, made me more talkative and emotional than MPH. It also makes one" stupid", and do and say things that are foolish or illogical. While not quite as bad, it reminds me somewhat of 4-MMC, with alot of useless and scattered cns stimulation. It made composing music very difficult, and impaired memory and motor control. As i continued to use it, the effect took on a distinct element of toxic psychosis. Now i have abused meth, cocaine and its base, 4-MAR, tenuate, d-amp and MPH to an equal or greater extent then the MDPV trial, but never experienced toxic psychosis to the extent I did with the MDPV. The first 6 days or so were ok, but by day 7 (i slept every night, no sleep deprivation due to use of sleeping agents) i started feeling" shaky", confused, heard some vague auditory hallucinations (not voices, just hearing sounds or noises, like my doorbell sound like it rang but didn't). By day 8, things began getting strange. I experienced a symptom of toxic psychosis I have NEVER experienced before: I began feeling that people were" looking" at me, a sort of paranoia I have never felt. Finally, at day 9-10, i was overcome with dysphoria, and felt too shaky and frightened to safely drive or work, so I called in sick. It reminded me of a LSD trip i once had, where I was driving and attempting to make a right turn onto a surface street, but the cars appeared to be moving so fast that i had to wait for a greenlight to turn. At this point i decided i had enough, and discontinued immediately. The following day i felt off, the day after that, almost normal, and the third day, back to normal.

I believe that this drug, at high doses (80mg/day+) possesses serious risk for toxic psychosis, and for some, addiction. I have a large amount of self-control, so i was able to stop immediately and not redose. I believe this drug has little therapeutic value. Its toxicity is unknown; it does not appear to be extraordinarily "toxic", but it is a powerful psychotomimetic and is inherently neurotoxic. At the doses i was using the serotonergic properties are undeniable, and may contribute to the toxic psychosis. MPH can cause toxic psychosis, but even at heavier abuse, it is not as extreme as MDPV. I have smoked many grams of cocaine base straight, without sleep, and while the body load was heavier, I never felt like" everyone is staring you".

The drug is not a great recreational drug (more so than MPH due to SERT binding), cocaine is far superior. It also has almost zero value in a clinical setting, it only aggravates ADHD. Continual use of this compound will most definitely lead to toxic psychosis. It is the only intranasal stimulant I've come across that made me feel unsuitable to drive. While i am against scheduling of any compound, i wouldn't shed a tear if this was. The availability as "bath salts" to any moron at a headshop is a recipe for disaster. If someone not used to stims takes a cocaine sized line of this.........problems will occur. MDPV will not come up in blood toxicology reports, but most individuals will have other compounds in their system in the event of overdose. If a non-tolerant individual were to snort "only one bag" of the 250mg bath salts, this could easily lead to a fatality.

If you use it, do so in moderation. The NIDA and DEA are both reviewing this compound for scheduling. Id like to go after the distributors of the "bath salts", the blood is truly on their hands, and they don't give a fuck about scheduling. They just want to profit while they can.
 
Man, I never had anything like this but I also never dosed about 5mg except for once. I'm starting to wonder if the original 2006 sample of the drug I tried was even this same drug. I never had any visual disturbances or hallucinations and I tend to be very sensitive to these effects from 5HT ligands.
 
The 98.9% pure MDPv compound was bought not from an 'RC vendor' if tnat helps). It was white-eggshell in color, and again, not sold by an RC vendor. The bath salts were less pure but still felt pharmacologically 'similiar', although there were some differences. It was obvious that the bath salts contained significant amounts of MDPV, and was a light tan-off white color. But keep in mind, i was using 100mg + a day, but i do have moderate tolerance to MPH. The bath salts hada higher body load and likely contained compound. There were similarities in taste, although the pure compound had a sharper taste and was more painful on inhalation.

My case is quite different, i am not extremely sensitive to mild 5-HT activation, but in this case it was crystal clear. Again I've taken most stimulants in this fashion ans not once felt" everyone is looking at you". That was a signal for me that the 'experiment' must end. I cannot speak for those at 5mg a day, i just wanted to mention the particular risk for toxic psychosis with extended usd at dose.


And like i said, i feel completely back to baseline now. Just a note of caution..........
 
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Excuse my total topic diversions, sleep dep does some crazy shit and so one who is insane but sane within ala me. I'm a fairly experienced in the world of psychoactive drugs. I've been doing the PV (Hot Rail Time Machine,The Secret, Gasm, Snow, Perv, Psycho Sister, Crackstasy, among many other names I call it..)" for 3 months in a somewhat excessive way.. Haha some might ask "are you Jesus or fucking retarded?". I might just be both oO Anyways I tried one of the bath salts at first and loved it a lot but ordering that gram was the turning point. I started out pretty good but shit changed by my 3rd order of 9g. It was all gone in 12 days... Don't worry I shared A LOT and departed with another ammount.. My prefered ROA is insufflating 5mg-30mg lines+ in one session lasting 3 days I could easily go through a gram maybe more most is probably 500mg in a day with another friend and have before (It's not really cool, after a while you get high for 10 minutes it seems and the rush is no where near that first satisfying line of the day) followed by minor fatigue for 2 days afterwards.. bleh no real depression mainly bored but interestingly the opposite depressing-wise.

I've tried smoking it with BS+drop of water and just pure and personally they both suck, unless you prefer the fucked up tweaky feeling the urge.. no sorry "pure compulsion" to talk with a british, arabian, hispanic, or austalian accent (comparable to my acid experience only not accents. No mental filter) and what hooks me is how the high is so diverse with this tool. I can eat and sleep on it now no problem.

I've gone maybe 7 days without it altogether since starting. 3 days was my longest but my efforts were thwarted. From the second I wake up on the comedowns, I have MASSIVE munchies, comparable to MJ if not more (wtf?). Those 3 days were really boring and lethargic too, I barely had the energy to roll a cigarette and step outside. I'm an upper person through and through. Opiates and Benzos were never really my thing since I'm a pretty chilled the fuck out person as it is. Stimulants just organize my thoughts really well and allow me to enjoy otherwise boring or unbearable tasks.

I don't get paranoid on it at all really but I see some of my friends go into mild psychosis loops with it and that brings paranoia to a whole new level for them. I just really ignore it well or something because I see how they could feel that and don't fully believe it when those things happen with me. I've gotten into it once and got myself out within 10 minutes. It's a really intense, weird, and strangely awesome feeling to me. Sleep Dep + Weed + PV and I mean a bowl of high grade greenery and obviously pv is a surefire way to up the sketch factor. It did NOT calm me down the first couple times trying it. Psychosis was definitely felt in a very minor sense (haha oxymoron?) pretty quickly when I was alone. I'm talking full blown visuals but not quite at the diphenhydramine level trip (don't do benadryl to get high) It was amazing. My spirit was like talking to me like I was it's son and it had these other beings with it talking about me. That might sound scary but it wasn't really bad.

The peev brings out my OCD 10 fold sometimes and trying to remember the 3, 4, or 5 genius ideas I just stumbled upon will sometimes just make me anxious and frustrated which is why I've started to write my thoughts, things to google/research whatever and ideas on paper. I've always gotten INSANELY distracted with any exterior stimulation. I can only describe it as my mind being pond and anyone talking over me is throwing a rock in my pond. Anyways I must be leaving. I'll maybe edit later peace. love. happiness.
 
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My spirit was like talking to me like I was it's son and it had these other beings with it talking about me

Does this not only emphasize my point? Visual disturbances and paranoia is one thing, but hearing voices from "spirits" or "entities" suggests a rather severe degree of toxic psychosis. Not all people suffering from organic psychosis have paranoia, and some find their "voices" amicable or friendly. Yes, MDPV made me "feel" as though I was saying unique and profound things.....but at the center I knew I was not. When one looses this distinction they the lines of reality can become so blurred that they are nearly invisible. I knew that my feeling of "everyone is looking at you" was a result of toxic psychosis, and that people were not looking at me, however, the sensation did not go away.

Again if you are saying "my spirit was like talking to me like I was it's son and it had these other beings with it talking about me", and think that the toxic psychosis, as you put it, "was definitely felt in a very minor sense", then I would re-evaluate your use of this drug.

I have the ENTIRE gambit of psychedelics, of all classes etc, and only THREE times have I actually had auditory hallucinations vivid enough where "voices" spoke clearly to me in long conversations (sure, I have had auditory hallucinations from many psychedelics, but generally a sound, or a word). The first time it occurred with a single large dose of potent psilocybin mushrooms (had tried 6 grams of the same batch with strong effects, assumed that 14 grams would be proportionally stronger.....I was wrong, it was exponentially stronger, true horror). The second time was with a large vaporized dose of N,N-DMT, which was much less "negative", but more unearthly (the room I was sitting in suddenly had tropical vines growing up the walls and an "alien" appeared playing some other-worldy music on a strange instrument). The final time was with datura seeds......I'll leave it at that, I don't like to think about it (I remember bits and pieces). Sure I have taken drugs that have made me "talk to myself" so to speak, but only 3 times have I heard voices other than my own, telling or instructing me to do things. IM ketamine or sub-anesthetic nitrous will make me "talk to myself" in a weird head-space, but only in my own voice and only to myself. And yes I have done it all (virtually), 5-meo-dmt was so overpowering that I had no auditory shit, purely visual and even loss of consciousness. Large doses of LSD, though highly visual, never made me hear voices. Even 5-meo-dipt or DPT only "altered" my hearing, but again, no voices.

The bottom line is, aside from long-term possible neurotoxicity, any sustained MDPV use possesses a HIGH risk for acute TOXIC PSYCHOSIS. Again, I have used many, many stimulants, and never had I experienced as rapid or acute toxic psychosis. It was bordering on the edge of me believing it....which is a very dangerous place to be. I was honestly surprised. Why is this the case, when MPH does not induce this? It must be 5-HT mediated, I am almost certain of it......

Take caution with this substance. It will be banned in the coming future, partially because of the profiteering, and partially due to toxic psychosis requiring hospitalization. If you can't handle your RC's, do not squeal at the hospital because that information IS reported. You are unlikely to run into a physician like me who will not report it. But i'm no longer in rotation so I don't encounter these individuals frequently......

I myself OD'ed on a legal qualone, and kept my mouth fucking shut.....Obviously if its medically relevant than yes, but in my case, I had already been intubated and most fluids had been removed from my lungs when I eventually woke-up in the ICU. The tox did not pick it up. This is the only drug upon which I have overdosed, and it was near fatal. While I weigh all things and test for purity, I did not respond to lower doses, and when I bumped it up, that narrow therapeutic closed down on me.
 
I wonder how many people post here while stuffed to the tits on mdpv?
Having said that,although I like the minor amount of energy I get from mdpv,I rank it pretty crappy next to amphetamines and Ritalin. For me there isn`t much euphoria before the side effects kick in. But I do like the low dose and availability of it.
 
Nuke, as to the product you received, it easily could have been a different compound.......I still have an unknown number of grams left of the "pure" white lab grade stuff (I was sent some.....for free, by someone at a university who owed me a favour). Do not believe any RC vendor claiming 99% purity because that is bullshit, even this lab grade stuff is not 99% according to my MPA. Also understand that these bath salts HAVE been found to contain neurotoxins like 4-fluoromethcathinone, 3-fluoromethcathinone and other sub-cathinones/stimulants. The sale of these salts have apparently been restricted in Florida, and will eventually be banned on a federal level. The DEA, NIDA, ACMD etc are well aware of its existence and wide-spread abuse already looking to schedule it.....

Check out:

http://www.namsdl.org/documents/ACMDCathinonesReport.pdf

http://www.deadiversion.usdoj.gov/drugs_concern/mdpv.pdf
 
thanks for the links negrogesic. It`s a bummer that the cathinones will be banned soon(ish). I find methylone to be the best of them. It`s too bad that greed heads have thrust these chemicals into the public spot light and ruined what many consider to be a good thing.
 
Hey guys - i started an account hear for this reason alone and for this forum which i thread that i have been reading a lot- very helpful and entertaining by the way. I recently - last three weeks - bought two bags of MDPV - 1 g and 10g - seemed all good til a few weeks ago i started smoking it. i am smoking it al the time and the parinoia was an issue then i took some of my GF olanzipine and it curbs that. First few time s i took the olanzipine it helped alot and it doesn't seem to anymore. I have read alot of info on this drugs pretty weel destrotying some people and i think some is true but alot is bullshi. Anyway - i have been smoking alot and i cant stop myself even thoough i really dont get high anymore - just m,ore and more anxious. I have trie to give it away and i got it back by lying - had my GF hide it but i found it and hide a secret stash - ihave miss ed work twice - thought i was dying a bunch - until the olanzipine. I understand addiction since i used to have coke issue that i was able to clear up by staying away from the drug and the crowd. what can i do or what can i do to help myself stay away aside from flushing it? my heart rateand blood pressure are always way up - like 140 beats. I want to get away for a but i do enjoy it or i did - with coke i could deal as long as i moderated it but i never had 10g of coke arond me at all times. you guys seem to know whats going on and without preaching and all that shit. Do you have any advice from me. I can stop for awhile but i always come back to it and im worrying im gonna do some serious \my herart and lungs. Plus i don't wanna end up with a psychotic episode like some reports i read - although i have done a shitload of it - easy 6 grams or more in maybe a little over a week all smoking. orry about the spelling but my keyboard is tiny my pother one is facked from some pop i spilled I'm gonna be sitting here vaping away til around 7 am when my GF comes home then im facked for checking this \thread here. OH and i work from home so i smoke it constantly. Please give me some advice or i think im gonna end up im some serious trouble. I do realize 10 g is alot but at the time i orderd it i had no idea what it was - should have done research first. one last thinng - i have long soincer stopped measuring this and just dump small mountains on the foil at this point. tolerance is high ----wanted to add i am sure it is mdpv the supplier is legit and respected. I haven't heard reports of anyone dying but i mean - someone has to go first right? and if ihave to toss this stuff i truly dont think i can - aklso have little tingles and strange pains all of\ver e\weird places - heart rate is still fast too but not as hard s it used to be on this. praying for someone to reply soon
 
Hey guys - i started an account hear for this reason alone and for this forum which i thread that i have been reading a lot- very helpful and entertaining by the way. I recently - last three weeks - bought two bags of MDPV - 1 g and 10g - seemed all good til a few weeks ago i started smoking it. i am smoking it al the time and the parinoia was an issue then i took some of my GF olanzipine and it curbs that. First few time s i took the olanzipine it helped alot and it doesn't seem to anymore. I have read alot of info on this drugs pretty weel destrotying some people and i think some is true but alot is bullshi. Anyway - i have been smoking alot and i cant stop myself even thoough i really dont get high anymore - just m,ore and more anxious. I have trie to give it away and i got it back by lying - had my GF hide it but i found it and hide a secret stash - ihave miss ed work twice - thought i was dying a bunch - until the olanzipine. I understand addiction since i used to have coke issue that i was able to clear up by staying away from the drug and the crowd. what can i do or what can i do to help myself stay away aside from flushing it? my heart rateand blood pressure are always way up - like 140 beats. I want to get away for a but i do enjoy it or i did - with coke i could deal as long as i moderated it but i never had 10g of coke arond me at all times. you guys seem to know whats going on and without preaching and all that shit. Do you have any advice from me. I can stop for awhile but i always come back to it and im worrying im gonna do some serious \my herart and lungs. Plus i don't wanna end up with a psychotic episode like some reports i read - although i have done a shitload of it - easy 6 grams or more in maybe a little over a week all smoking. orry about the spelling but my keyboard is tiny my pother one is facked from some pop i spilled I'm gonna be sitting here vaping away til around 7 am when my GF comes home then im facked for checking this \thread here. OH and i work from home so i smoke it constantly. Please give me some advice or i think im gonna end up im some serious trouble. I do realize 10 g is alot but at the time i orderd it i had no idea what it was - should have done research first. one last thinng - i have long soincer stopped measuring this and just dump small mountains on the foil at this point. tolerance is high ----wanted to add i am sure it is mdpv the supplier is legit and respected. I haven't heard reports of anyone dying but i mean - someone has to go first right? and if ihave to toss this stuff i truly dont think i can - aklso have little tingles and strange pains all of\ver e\weird places - heart rate is still fast too but not as hard s it used to be on this. praying for someone to reply soon
 
Nuke, as to the product you received, it easily could have been a different compound.......I still have an unknown number of grams left of the "pure" white lab grade stuff (I was sent some.....for free, by someone at a university who owed me a favour). Do not believe any RC vendor claiming 99% purity because that is bullshit, even this lab grade stuff is not 99% according to my MPA.

I think me and solipsis received samples of the same compound and he will have his analyzed shortly... The only thing that ever happened when I took my MDPV was me becoming more chatty and unable to sleep or solving advanced mathematics problems at breakneck speed. Nanobrain had noted serotonergic effects with the same sample, though. We'll have to see what the results are I guess!
 
I know someone who is addicted to mdpv the way you would be addicted to methamph...



I would think even though it is an MDXX, FAB is right about the probably insignificant effect on SERT (although im sure there is some), but i do think its probably neurotoxic (no evidence, of course) in the same way as amphetamine is, assuming use is frequent... plus, who knows, an MDXX-series chemical used daily definitely sounds like bad news to me.

Anyway, this friend had partial amnesia from MDPV after 3 days of use and an amphetamine-like psychosis. I dunno whether this was a 3 day full-on tweekend or just 3 doses spaced 24hrs apart but either way, I would definitely use with caution and id THINK its about the same as using methamph or methcathinone.

Of course, there is no KNOWN neurotoxicity, but do you guys think its safer than amphetamine and/or meth? How bout addiction potential?
that shit it baddd.. ive been doing it like a week straight... i have alot of experience with many different drugs .. ive done alot of coke and e pills... i ended up shooting dope ... but that shit is no joke ... the only reason im not in a phyc ward is for the fact that i have experience with drugs and know how to control the phycosis but i barely can and i did IVORY WAVE and i think each package is 500mg and a package lasts me like at least 3 days ... i was snorting very little lines and only a coulple a day... the first time i did it .. i think 2 very very very tiny lines lasted me all day... but its not a good idea to do unless you can control your brain ... if you cant you will get phycosis and theres alot of other things that can happpen... like it makes ur heart rate increase so if u freak out and make it increase even more you can end up killing urself
 
"How dangerous is MDPV"...

IME, MDPV is as dangerous as I am, in my belief that I have control over the compulsiveness of dopamine and "can stop any time I want" when it's lying around and available. So it's dangerous if I think I can buy it in large amounts, stash it away and choose when to use it and when not to. Otherwise, it's not that dangerous.

P.S. like all dopaminergics, MDPV is quite capable of causing full blown (temporary) psychosis in high doses/over long periods... don't know why this would surprise anyone. It's a damn good teacher in terms of knowing/setting your limits before you start messing with it.

The freakiest thing about psychosis is the questions it raises about what's real and what isn't, because you were *so damn sure* that what you were experiencing was real. But in the end, you were just under the influence of a drug.

but i do think its probably neurotoxic (no evidence, of course) in the same way as amphetamine is, assuming use is frequent...
Actually, it's probably not, as amphetamine is neurotoxic due to being a dopamine releaser (rather than a reuptake inhibitor like MDPV). But I don't know for sure. I always seem to recover from it surprisingly quickly/completely, fwiw, simply by stopping its use.
 
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any one know what a "safe" dose of MDPV would be? i tried it to day i don't have any thing to weigh it so i cut the 200mg in half in to 100mg and cut it a little less then a 4th and did it that way. i redosed as i felt like it over the day im guessing and going to say i did a little over or under 100mg and im not feeling anything negative so what would the most that should be done over the day? and what would be the best way of doing it?
 
well its 185mgs down since 3pmish to now 4:55am i think ill save the rest for tomorrow/well is today but later =] id say this stuffs is pretty good i know i like i really debt sleep will happen to night but no biggy thats kinda norm for me at times =] still no negatives so far my back kinda hurts but thats due to sitting at the computer for hours watching anime =] !!! it kinda feels like the first time i downed a Red line Xtreme =]
 
i just got up no problems had gotting around 5 1/2 hours of sleep no weird heart crap. Now a day after drinking my heart beat would literally make my bed shake! and it would be like that all day long /my mom told me that she would get like that and thats why she stopped drinking something about her high blood presser and that i my have it as well/ that being said i really thought this would do the same but lucky me =]
 
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