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MDPV - So how dangerous is it?

Scheduling another compound is the last thing we need. Yes, it is largely the profiteers of these mass produced formulations who are responsible for getting it into the hands of people who probably are not fit to be drinking coffee.

And yes while technically speaking, compared to cocaine, MDPV has a lower Ki value at the DAT (i.e. it has higher affinity), which explains the desire to self-administer, but it has nowhere near the affinity for the SERT. It does have some however, but in very disproportionate ratio to the DAT/NET, whereas cocaine is a very "balanced" reuptake inhibitor of the DA/NE/5-HT. I believe in self-administration studies, blockade of the cocaine's 5-HT reuptake inhibition DID reduce self-administration. But certainly, (as we can see with d-methylphenidate, a potent DA/NE reuptake inhibitor with no affinity for the SERT), that compounds like MDPV can elicit great desire to re-dose.....but it does not beat cocaine in self-administration/reinforcing properties. And qualitatively, in humans, cocaine will be chosen over a compound like d-MPH. However, d-MPH can pretty effectively substitute for cocaine in cocaine-trained laboratory animals, but then again, i believe cocaine-trained rats will self-administer magnesium chloride in the presence of cocaine, but is a poor substitute (don't try snorting magnesium chloride......i bet it hurts)......

Point is, just because you feel the need to reuse it doesn't truly make it more "addictive".......D-MPH when inhaled will provoke the need to reuse, but in humans does not have the same abuse potential as cocaine. Same as the case of MDPV......if you try to substitute MDPV to cocaine-trained humans (colloquially, "crack-heads") you will probably get stabbed.....
 
negrogesic said:
Point is, just because you feel the need to reuse it doesn't truly make it more "addictive".......D-MPH when inhaled will provoke the need to reuse, but in humans does not have the same abuse potential as cocaine. Same as the case of MDPV......if you try to substitute MDPV to cocaine-trained humans (colloquially, "crack-heads") you will probably get stabbed.....
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Let's not overlook cocaine's short duration of effects as well, which adds to its compulsiveness. Dosing MDPV (with a 4 hour halflife) as frequently as coke will screw you up bigtime.
 
ektamine said:
Quite simply, 'cause of sensationalist soccer moms and the DEA ;)
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Yeah... That will be by far the best RC to be made. And Ive tried all of 018s brothers and sisters.... nothing is the same. And then I was introduced to PV/Meph.... good God. Its def a Love/Hate relationship.
 
BigMoMo123 said:
Yeah... That will be by far the best RC to be made. And Ive tried all of 018s brothers and sisters.... nothing is the same. And then I was introduced to PV/Meph.... good God. Its def a Love/Hate relationship.
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IME, the amount of rest you've had has when doing it has a lot to do with how much love, and how much hate... you can't get blood out of a stone.
 
Tramadol M1 is the all-star of RCs.............MDPV is, as once referred to here.......as mere'vagrant'...........that cryptic reference should be clear to those whom haved been here a decade.....

On a personal note of great irrelevance MBDB was a much" nicer" and friendy compound............
 
negrogesic said:
Tramadol M1 is the all-star of RCs.............MDPV is, as once referred to here.......as mere'vagrant'...........that cryptic reference should be clear to those whom haved been here a decade.....

On a personal note of great irrelevance MBDB was a much" nicer" and friendy compound............
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Thats a metabolite of tramadol right? Are there qualitative differences between taking tramadol or taking exclusively the M1 metabolite?

If it feels the same a tramadol, I'd prefer MDPV actually. But I guess thats just a matter of stimulant vs. opiate preference.

negrogesic said:
.MDPV is, as once referred to here.......as mere'vagrant'
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Heh, are you referring to MDPVagrant?
 
okkk then

well me and my mates were sold something that was labelled as bubble but the effects are slightly different to mcat... it gives you the typical buzzing characteristics but makes you more spaced out... in a world of your own... we started off on 0.2g and that lasted 3hours i've done 1.5g in 11 hours... the lasting effect is immense about twice as long as bubble... i wonder what this is??? also it makes your heart race we were getting heart rates of between 100-160 and blood pressures raging from 120/70 to 190/100
 
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Dedbeet said:
Say whaa? Tramadol isn't a RC, it's a prescription drug.
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"M1" is a metabolite of tramadol (in addition to being a stupid name for Methylone), and I think I've heard talk of RC vendors stocking it in the past, on another major drug forum.
 
I thought i'd post here as it's really an ADD question but to all the more scientifically inclined out there.. Has anyone attempted any characterization of PV with DSC?

The reason i ask is that one of the most interesting properties of PV, to me anyway, are it's very different effects depending on smoking ROA. On foil i have observed a very stimmy, not very pleasant effect, lots on the physical side etc. When heated carefully indirectly and allowed to pass through the air not at room temp but surrounded by very hot air, ie in a heated pipe i have noticed a massive reduction in physical stimulation and also a very I want to lie down much more euphoric effect.

Basically the thermal decomposition products at very specific temperatures seem different to PV completely. Before i get accused by ignorant peeps of being stuffmonger or similar, be interested to hear scientifically sound suggestions.

There are a range of melting points, typically where the first to come off is generally quite stimulating, perhaps this could just be impurities, but nevertheless I find it's thermal history when heating a cooling worth hearing about.
 
negrogesic said:
And yes while technically speaking, compared to cocaine, MDPV has a lower Ki value at the DAT (i.e. it has higher affinity), which explains the desire to self-administer, but it has nowhere near the affinity for the SERT. It does have some however, but in very disproportionate ratio to the DAT/NET. . .
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Do you happen to have any of the relevant binding affinity data handy? I wasn't able to find much with a cursory search of google scholar.

ebola
 
Pralus said:
Before i get accused by ignorant peeps of being stuffmonger or similar
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lol, I think we're gonna have to coin a term for that.

stuff·mon·ger phe·nom·e·non –

The mysterious law dictating that whenever a bluelight user mentions that MDPV may degrade into other chemical(s), he/she will be shunned by the masses and labeled as a 'stuffmonger', simply trying to advertise his/her shitty product from the middle of the jungles in belize, thereby preventing further intelligible discussion.​
 
Again, that was from memory. My assertion that MDPV has very weak (but greater than D-MPH) affinity for the SERT is subjective, real the following following full-text for the break-down.

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors, Full-Text

In regards to D-MPH, i know from memory that its Ki for the SERT is >5,000nM. This may be a bit off, but I also believe the of uptake inhibition of DA/NE/5-HT for cocaine is roughly something like ~500nM/800nM/300nM (obviously, Ki values). That is a pretty nice ratio. Notice that DAT and SERT affinities exceed that of NE (again, subjectively, what makes it enjoyable). I believe those numbers are from the Baumann/Rothman data.....it was in an old MCB "drugs of abuse" companion text....
 
Thanks for the link. They used cocaine as a contrast compound, it it roughly corroborates your description.

It looks, though, that the ratios of SERT activity to DAT or NET Kis for MDPV are rather similar to d-amphetamine's, suggesting that activity at SERT shouldn't play much of a role in its effects except in cases of massive doses (which people take with MDPV :P).

ebola
 
Again, the 5-HT activity seemed very low, but at higher doses, pharmacologically active. My perceptions do not substitute for a radiolabelled assay, but I've taken enough compounds to 'get a feel' for this (the human body, though biased, is a rather sensitive instrument). D-MPH, is devoid of 5-HT activity, even at large doses. But, the bottom line, MDPV has a terrible ratio of DA/NE to 5-HT reuptake inhibition relative to cocaine.......which again, is king among "common" stimulants (sure methamphetamine has impressive numbers.....but sujectively....). Either will ruin ones life is abused extensively, but the cocaine addict will have more fun along the way................

So how toxic is MDPV.....probably more so than d-MPH............the moral of the story, stimulant addiction is unsustainable and a recipe for irreversible cognitive defecits......
 
Just ordered a gram for my upcoming birthday. Never tried it before and am pretty nervous based on what you've all said. Does anyone have anything positive to report about MDPV?
 
Lady Codone said:
Just ordered a gram for my upcoming birthday. Never tried it before and am pretty nervous based on what you've all said. Does anyone have anything positive to report about MDPV?
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If you like the darker, tweaker, more animalistic and sexual euphoria of dopaminergics, you'll like MDPV. It can get too tweaky if you overdo, though... just be cautious and you should be fine. People tend to either underestimate its capability to tweak you out, or chase the euphoria straight into tweaksville. Watch out for this tendency from the start, and you should have a better experience.
 
THANK YOU for the reassurance! I'm ridiculously conservative with my doses of all drugs, and plan to start with literally a few grains (powder, whatever) of MDPV and work my way up just to be safe.

I'm seeing a lot of reports of auditory hallucinations. Is that caused by large doses and sleep deprivation or is it inherent in the compound itself?
 
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