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MDMA absorption rates by routes of administration

i'm over oral route of admin. i nearly always get nausea and sometimes some pretty nasty dry heaves on the come up - but afterwards i feel fking brilliant. sometimes absorbtion is not 100% complete when what little content is in my stomach comes back up.

so what i want to know, does plugging beat the unsettled stomach?
 
Yes kizinja it does stop nausea, you shouldn’t feel any at all, however you may feel a slight urge to defecate, just ignore that as best you can.

For all those who asked how far, I haven’t heard the second knuckle idea before, but if you know your body (and you should if your taking goodies) simply push it past your sphincter muscle, it wont be coming back out unless you ask.

And D J Wave, great research!!! I will crush it next time.




:) :)
 
^^^ cheers, tested, works :)

as for the original figures being fabrications, it's clearly well known supositories are a all round more effective method of absorbtion for a wide range of drugs.

i'm sure i've skimmed over it in a textbook... while there's no specific research on MDMA anyone could find, i'm sure there's tons of applicable research.
 
will here we go heres my input: ive been rolling for about a year now the only way that i havent taken a pill is by injecting it or smoking it. my experiences are that if i snort it, it will hit me in about five minutes but ill only peak for about an hour to a hour and a half. if i let it sit under my tongue it has a bad tasted and i roll for about two to three hours. if i swalllow it straight up(which i only did my first time) then i went for three hours. If i crush it up wrap it in a paper towel (parachuting) then swallow the whole thing ill go for about four to five hours. Now heres the best part by taking it rectally ive only put it in untill i felt i was past my sphincter and that was just to my first knuckle and every time ive done that ive always rolled my balls off for six to eight hours, garuntee!!! Now my girl has put it up her vagina three times and it only worked the first time but when it did work she rolled harder than me for the same time it was like a seven hour orgasm, it was awesome!!! so if you do put it up your vagina be real self conciouse on sitting down for about a half hour afterwards.

for me i always booty bump it now every time and im on tiger balm like its going out of style. i hope this helped and didnt make this discussion more confusing.:)
 
vagina is acidic

The pH balance of the vagina is acidic. So sticking things up there would be about as good as eating it. Lord knows whats in the binders so a possible Vaginal infection could incur.
I believe that tiger balm is an oil base, try using KY and see if that bumps ya up another notch.
When you do the booty bump do you crush your pills or leave solid? Im assuming you crush and jellcap.

One question is I belive pluggin Meth is bad. Burns like a mofo. So, if you got a pill with meth would it cause a good amount discomfort?
 
im sorry i meant that when i do roll i inhale tiger balm like its going out of style, sorry about that. when i do bump it i do use a water based lubricant. i leave the pill in solid form, ive never thought about crushing it, unless i snort it. yes it does burn it acuatlly burns to the point that i just want to sit down for about a half hour untill it stops, but the benefits that i do recieve from it are by far worth the slight bit of uncomfortablness without a doubt.=D =D =D =D
 
LOL plugging is more effective because 88% of all nutrients are absorbed in your intestines going the oral route to the intestines, so sticking E directly in the butt automatically absorbs 88% at 1 time thats why its more effective. Personally I like it yea it feels weird but when it hits it hits!!
 
Care to back those figures up? The whole point of this thread is that saying stuff like "Plugging is 90% efficent" doesn't seem to have any backup in any medical literature.
 
The rectal route is often used when vomiting precludes oral ingestion or when the subject is unconscious. It should be noted, however, that up to 83% of rectal medications such as lorazepam or diazepam will be absorbed within a 15 minutes from administration, but may often wear off quicker because of such a high absorption rate. Rectal absorption may often be irregular and incomplete and many drugs cause irritation of the rectal mucosa.

Brady Emergency Paramedic Care 8th edition
Micheal F. O'keefe 1998
Chapter 16 General Pharmacology page 305
 
I know this is talking about valium and ativan which is only given rectally for seizures but it was the closet thing I could find
 
Erm that thread talks about the time-rate of absorption... all benzodiazepines will be (essentially) completely absorbed no matter the route of administration -- its just how fast it gets there.

This topic is trying to dispel rumours that suggest you get a set percentage MORE by rectal administration.

i.e: There is a difference between the total fraction which is absorbed and the rate at which it is absorbed. Your references supports the latter, not the former.
 
Parachuting

Kinda of a newb - but responsible with intake etc

Hoping someone can enlighten me as to Parachuting - what this actually involves - any theory that may apply - and then some practical info - how much paper to use etc

Some info would certainly be appreciated
 
Absorption rate

Interesting discussion. I currently work within the Pharmaceutical industry and to the best of my knowledge, there have be no controlled scientific studies into the absorbtion rate of Ecstacy.

One of the problems is that there is such a wide variance in the content of the pills, that it is next to impossible to compare them.

As to plugging pills. I am aware that in certain medical conditions and emergencies the medical community advocates the rectal insertion of certain drugs. The reasons for this are 2 fold.

1. Drugs are absorbed much, much quicker through the rectal mucosa (lining). In some cases up to 10 times faster. So those that say a pill comes on quicker are absolutely right.

2. Some medications are far more effective as the directly into the blood supply without being altered by the gut (called the first pass effect). Whether this is true for pills I do not know.

I do know that the first time I plugged a pill I really needed to take a dump after. This is common with anything inserted anally.

Hope this information is useful.;)
 
Making it last

Forgot to mention in my last post that the use of a serotonin reuptake inhibitor such as Aurorix (Australian) will also help ensure that the effects of a pill lasts longer. This is due to the fact that it helps to prevent the reabsorbtion of seretonin by the body.

Basically Serotonin is the substance in your brain that helps make you fell happy and relaxed
 
MDA IS A LOVE DRUG

I used to shoot mda....it really is an enlightment to me....ringing like crack...mellow like smack...visions like scrooms....and empathy for you humans
 
Those of you who crush up pills and wrap them in paper towls might like to try a rizla instead,you can lick the sticky bit and fold it in half to make a neat little envelope into which i've found you can fit about 4 standard pills-easier to swallow too.
Also i was wondering if anyone know whether or not this method could also be applied to plugging?.i.e will the rizla break down sufficiently to release the contents?
Plus when i bosh pills,and i'm sure i'm not alone here,i always need a really big shit during the come up.Will this happen with plugging and how long before i can safely go without the fear of wasting my pill?
Thanx for any input.
 
Well i tried plugging half a pill last night,my mates gave me so much grief but i thought i'd try it anyway.It was a petrol pump,which are shit at the best of times,but wow it felt like i'd dropped a whole good quality pill.Gonna try it with a whole one tonight.Can't even get any of my friends to consider the idea though,they think its a bit gay!!
 
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