Drug designs. (MedicinalUser SAR thread)

[MedicinalUser247]

That looks cool.

 

[MedicinalUser247]

Here's a real easy one. 3,4-Dihydroephedrine. It's dopamine mimic without being toxic.

 

[Rectify]

1-(3,4-dihydrophenyl)-1-hydroxy-2-methylaminopropane

Meh

 

[MedicinalUser247]

Well it actully looks more like dopamine than that.

 

[MedicinalUser247]

If you want a difficult one you can try drawing 25I-NBOMe with two Methylene dioxy's replacing the methoxy's.

 

[MedicinalUser247]

https://en.wikipedia.org/wiki/25I-NBOMe

 

[Rectify]

The name you gave me must be wrong then. Here I thought of an improvement.

Well it actully looks more like dopamine than that.

 

[Rectify]

So you're looking for dopamine?

1-(3,4-dioxophenyl)-2-methylaminopropane

 

[MedicinalUser247]

Yup, and then cross it with Ephedrine.

 

[MedicinalUser247]

The thing is when you have two hydroxyl's like dopamine you can't make an amphetamine out of it because it's neurotoxic. That's why you need the Ephedrine structure as a substitute.

 

[Rectify]

N-(2-(2,3-methylenedioxy-4-iodo-5,6-methylenedioxyphenyl)ethyl)-N-(2-methoxybenzyl)amine

 

[MedicinalUser247]

Now that's a powerful hallucinogen.

 

[MedicinalUser247]

This one looks kind of odd. It's 2,5-Dimethoxy-3,4-furazan-Phenylmethanamine.

 

[Rectify]

The thing is when you have two hydroxyl's like dopamine you can't make an amphetamine out of it because it's neurotoxic. That's why you need the Ephedrine structure as a substitute.

Is ephedrine stronger than meth?

 

[Rectify]

What do you think of this as a drug?

4-HT (4-HydroxyTryptamine)
1-(4-hydroxyindole-3-yl)-2-aminoethane

 

[Rectify]

I beg to differ that you can't make an amphetamine out of dopamine. Compare the structures of the following compouns.

MDA
1-(3,4-methylenedioxyphenyl)-2-aminopropane

DOPAMINE aka DA
1-(3,4-dihydroxyphenyl)-2-aminoethane

There is only a difference of 2 carbons between them. The alpha methyl carbon makes the amine last longer, while the methylene C caps off those 2 aromatic hydroxyl groups making the molecule more lipophilic / hydrophobic so as to cross the blood brain barrier to the brain better.

 

[MedicinalUser247]

Is ephedrine stronger than meth?

Of course meth is stonger, but adding two hydroxyl groups to meth makes it neurotoxic when you place them in the same position as dopamine.

 

[Rectify]

Those are not hydroxyl groups (R-OH's) but rather oxo (R-(C=O)-R') groups. Also, the dioxo meth compound is a metabolite of MDMA.

 

[MedicinalUser247]

I wanted to design 3,4-DihydroxyMethamphetamine before, but skorpio told me that making it would be neurotoxic. So, I kind of trust what she said.

 

[MedicinalUser247]

There is a way around that though. Instead you could make 3-Methoxy-4-Hydroxy-Methamphetamine. That would work.