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  • N&PD Moderators: Skorpio

Drug designs. (MedicinalUser SAR thread)

1-(3,4-dihydrophenyl)-1-hydroxy-2-methylaminopropane.png


1-(3,4-dihydrophenyl)-1-hydroxy-2-methylaminopropane

Meh
 
If you want a difficult one you can try drawing 25I-NBOMe with two Methylene dioxy's replacing the methoxy's.
 
The thing is when you have two hydroxyl's like dopamine you can't make an amphetamine out of it because it's neurotoxic. That's why you need the Ephedrine structure as a substitute.
 
I beg to differ that you can't make an amphetamine out of dopamine. Compare the structures of the following compouns.

1-(3,4-methylenedioxyphenyl)-2-aminopropane.png


MDA
1-(3,4-methylenedioxyphenyl)-2-aminopropane

1-(3,4-dihydroxyphenyl)-2-aminoethane.png


DOPAMINE aka DA
1-(3,4-dihydroxyphenyl)-2-aminoethane

There is only a difference of 2 carbons between them. The alpha methyl carbon makes the amine last longer, while the methylene C caps off those 2 aromatic hydroxyl groups making the molecule more lipophilic / hydrophobic so as to cross the blood brain barrier to the brain better.
 
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Those are not hydroxyl groups (R-OH's) but rather oxo (R-(C=O)-R') groups. Also, the dioxo meth compound is a metabolite of MDMA.
 
I wanted to design 3,4-DihydroxyMethamphetamine before, but skorpio told me that making it would be neurotoxic. So, I kind of trust what she said.
 
There is a way around that though. Instead you could make 3-Methoxy-4-Hydroxy-Methamphetamine. That would work.
 
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