Design your own Antidepressant Pill

[onlywant2nod]

everybody's body chemistry is as different from one to another just like there is no duplicate fingerprint found yet, everyone has different features, thats why to this day the pigs still use fingerprinting for evidence etc. What this all boils down to, is basically medications are not going to work exactly the same for everyone, however strangely people with treatment resistant depression(like me). For the most part, most of them will come to a time in their life where they will cling to opiates/opioids of some kind.

Its just too bad my depression was so bad for so many years before I found lovely vicodin 10/500, but that only last so long before you have to move up to something else due to tolerance, and speaking of tolerance this discussion has been about antidepressants as crap which they are but the one poster who was discussing tiny amounts of naltrexone or naloxone to lower tolerance or fool your brain into not downregulating your receptors seems strange to me.

I was put on a small amount of naltrexone in order to get out of rehab back when I first went into rehab just to ease the wd's of vicodin, well when I got out I felt 10x worse wd's than when I went in due to them having me on that crap twice a day, I quit taking that shit a day or two after I got home and my parents had wasted $400 on shit meds(no insurance) lamictal for depression and that crap naltrexone which I begged them not to fill at that price because I knew when I followed up with my psychiatrist that he would tell me to quit them both which I did and had to because one, the lamictal made me break out in bumps and rashes bigtime all over(a bad reaction to it) and he said to quit the naltrexone because even after 5 days of being on that crap I just could barely eat(no appetite) and was still in wd's bad.

2 weeks after I got outta rehab, I already had heard about naltrexone lowering your tolerance to opiates, well I got my hands on a ton of more hydro 10/500 thank god and my tolerance was not changed much, that was strange. However I was born with slight autisim and put in a special school and had a shitty childhood, but outgrew some of my disability but never all of it to this day. I think my body chemistry is just alot different than most because I am more sensitive to things than normal people and on and on. But what it all boils down to is opiates still remain the only thing keeping me hanging on, otherwise I would ended my life long ago.

 

[Tsukasa]

Wouldn't most of those be present in excess in a healthy or even moderately healthy diet?

Which 99% of depressed people don't have, and a lot of that stuff isn't found in a typical diet like D-phenylalanine (synthetic). I think that supplementing with large amounts of those nutrients would be the safest, healthiest, and most beneficial way to cure depression, especially when combined with moderate excercise, light exposure, positive thinking, etc. The carbohydrates wouldn't totally offset the other amino acids, but would allow more of the l-tryptophan to enter along with the others.

 

[grue]

FTR, generally speaking serotonergics (exceptions include MDMA) make me more depressed and apathetic.

(I think this is not an uncommon reaction at all for people with my particular flavor of anhedonic, demotivated depression with inattention and social phobia -- also a pretty common matrix of symptoms. Dopamine dopamine dopamine. Currently, I am doing tremendously well with memantine + d-amp.)

onlywant2nod, given what you say, have you considered long-term therapy with buprenorphine?

(as I've mentioned elsewhere, memantine as adjunct to buprenorphine would be even more interesting)

 

[serotonin-system]

Originally Posted by serotonin-system
Wouldn't most of those be present in excess in a healthy or even moderately healthy diet?

Which 99% of depressed people don't haveQUOTE]

Source?

I'd say the reality would be closer to the opposite. Even a pretty standard western diet likely provides far in excess of the amounts of amino acids, vitamins etc that we all need. The vast majority of which is excreated out unused.

 

[Tsukasa]

^ That's my observation. It's fairly unlikely that any the millions of people on anti-depressents have a healthy lifestyle, particularly diet. Most depressed people I know eat nothing but mcdonalds, pizza, soda, candy bars, and other junk food.

One acquantance of mine told me that kind of food makes him feel better short term, but looking back he says it ruined his life. Now he's fat, ugly, always tired, etc. I don't know if he's changed his diet yet, but it would serve him to eat healthier. Judging from his behavior and appearance he must have all kind of chemical deficiencies and clogged veins and arteries.

 

[haribo1]

I'm very interested in the protein Ziconotide. A lot of work still needs to be done, but I suspect that SSRIs & related won't be around as long as people generally think. Lets face it, an antidepressant that screws up your sex life is not... err... that clever...

 

[grue]

^I wasn't aware ziconotide was being researched in re: depression. From what I've read it seems pretty potentially toxic as the dose rises.

 

[haribo1]

^I wasn't aware ziconotide was being researched in re: depression. From what I've read it seems pretty potentially toxic as the dose rises.

So are the MAOI & tricyclic classes of antidepressants...

 

[morphiquet]

@tsukasa:

might be that people with an unhealthy diet don't get enough vitamins, but for this purpose there are craply cheap pills and the like available in every store.
considering the amino acids: what do you think does meat (or the patties in the burgers or any other meal we eat) consist of? -large amounts of proteins, which are cracked down by the intestines to every single amino acid you need.

therefore, i'd say that your supplementation is a pretty expensive nonsense.
please don't take this as an assault, it's just my opinion based on my very best knowledge

 

[Tsukasa]

^ Protein from meat is relatively difficult to digest. I would rather have whey protein from dairy sources to get my amino acids. However, protein isn't everything you need for healthy neurotransmitter levels. You also need carbs, fats, cholesterol, vitamins, and minerals. You can get all of those nutrients, but from a healthy nutrient-dense diet, unlike mcdonalds and other nasty unbalanced fast food. You want the most amount of nutrients, with the least amount of calories, because too much calories can make you feel tired and also satiated before you get enough neccesary nutrients.

A lot of the stuff I mentioned in my supplement cannot be acquired through a diet and must be supplemented, or they are only found naturally in insignifant amounts. I'm not proposing that it's some instant cure for any kind of depression. I believe that it's one part of wholeness. Why do you think they call it holistic therapy?

 

[serotonin-system]

^ That's my observation. It's fairly unlikely that any the millions of people on anti-depressents have a healthy lifestyle, particularly diet. Most depressed people I know eat nothing but mcdonalds, pizza, soda, candy bars, and other junk food.

One acquantance of mine told me that kind of food makes him feel better short term, but looking back he says it ruined his life. Now he's fat, ugly, always tired, etc. I don't know if he's changed his diet yet, but it would serve him to eat healthier. Judging from his behavior and appearance he must have all kind of chemical deficiencies and clogged veins and arteries.

Fair enough. I also think an important aspect of eating healthily is the psychological aspect of 'taking care of yourself'.ie for me if I go on a bit of a health trip I start to feel better psychologically but I think a lot of that might be to do with the fact that im trying to do something positive for me and look after myself, rather than as direct result the diet is having on my brain chemistry.

 

[serotonin-system]

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[serotonin-system]

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