N&PD Moderators: Skorpio
Design your own Antidepressant Pill
serotonin-system
Ex-Bluelighter
rickolasnice said:
That's a good way of putting it. There are so many aspects to being on an SSRI, and it's different for everyone. For me, I dont feel (so) afraid anymore, of everything. I also used to get what I'd call a 'negative buzz' in my head while depressed. This was a physical feeling of pain/negativity inside by brain which got worse when I tried to think/concentrate. Citalopram took that away.
Anyway, back on topic.....
thisusername
Bluelighter
10 mg extended release dextroamphetamine
30 mg extended release tianeptine
15 mg extended release selegiline
small dose of an extended release glutamate blocker
and a full and complete multivitaman, epa and dha, 12 mg of inositol, and half the reccomended daily dose of amino acid protiens
and perhaps 50 micrograms of lsd to enhance creativity, thoughts, quality of life, and to counter the ego enhancing effects of the dextroamphetamine
at night gbl could be taken along with 20 mg diazepam
we could also throw some resveratrol in there just for the fuck of it
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serotonin-system
Ex-Bluelighter
^Is that a daily regime?
thisusername
Bluelighter
serotonin-system said:
everything but the lsd which could be taken every 3 days.
serotonin-system
Ex-Bluelighter
thisusername said:
Cool. That was my concern about the LSD. I sill need to try this stff, but I consider set and setting so important I just haven't beel presented with the right oppourtunity yet.
Guess it'll happen, some day![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
Low dose LSD dosing seems to take longer to acquire tolerance anyway. A few posters here, like Church, seem to have had good results with daily dosing of "threshold" doses, Church having done it for 6 months iirc.
I think it could be a great capstone on d-amph+memantine+buprenorphine ...
Jamshyd
Bluelight Crew
50mics of LSD will not "counter" the egotistic effects of amphetamine, it will simply synergize with it and enhance those effects.
The low-dose LSD as antidepressant thing is not what most people think. The dose is sub-threshold, meaning that you must not feel the effects you normally associate with LSD with any intensity. At that level, LSD actually has a different mechanism of action that is lost at psychedelic doses.
Riemann Zeta
Bluelighter
^^Exactly. So, if this were something that I was expecting to take on a daily basis, I'd throw in:
60mg dextroamphetamine (Extended Release)
30ug LSD or 1mg ergometrine or 7mg dihydroergotoxine
750mg aniracetam
350mg trans-resveratrol or SRT-501
200mg dimethyltryptamine
Clearly, the DMT is not particularly orally active, but for light antidepressant purposes, we don't need a full-on trip-worthy dose, just a itty-bitty little amount to enter the brain and hit TAAR1 receptors. Also, obviously the daily ergoloid would ablate one's ability to trip.
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morphiquet
Bluelighter
60mg of amfetamine on a daily basis? don't you think you're a bit starry-eyed?
also, dimetyltryptamine and resveratrol would be completely useless for any antidepressant effects.
the former one, btw, wouldn't even touch ta-receptors, but i admit, that in the view of long term-effectiveness, one could at least argue about it.
Riemann Zeta
Bluelighter
^^I'm actually on 60mg of dextroamphetamine a day right now and have been for years. Works great and I've never accrued a tolerance to the beneficial focusing and stimulant effects, nor have I experienced any significant side effects. I guess I tolerate amphetamines extraordinarily well.
I'm not so sure about the DMT not even hitting the TA receptor--it only needs to be present in extremely minute doses to exert an effect there. Even if MAO-A destroys 99% of the active dose, it would still be enough (in theory, in practice, it is highly questionable if there would be any detectable psychical response). The resveratrol was thrown in solely for neuroprotective purposes, not antidepressant effects. Oxidative stress is bad shit, man--I want no part of it, keep those damn radicals away from me 
.
I'm not sure you're right. We shall see. I understand that the effects of low-dose LSD have been reported as mostly stimulating but I have also heard reports of some minor effects, which I relate to psychedelic effects, occurring and lingering on a daily low-dose LSD regimen: a stimulation of the associative and conceptualizing abilities, a sort of creative edginess.
If I can maintain those effects, I think they could significantly augment my experience of memantine + dextroamphetamine, which at the moment (6 weeks in) seems to have been working fairly well for offsetting tolerance to the motivating/mood effects of the d-amph, these effects typically fading after 2-3 days for me and which I feel to be actually more therapeutic for me than the duller concentrative effect, which lingers.
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Ham-milton
Bluelighter
Has anyone used memantine with a powerful psychedelic like LSD?
I'd imagine it'd significantly potentiate the LSD, though at what dose, I have no idea.
^Yeah, I'm not sure, but I would be pretty surprised if memantine didn't do something to the effect. I haven't had a chance to take any "5HT2a" psychedelics with my memantine regimen (30-40mg daily) yet. The current regimen has invoked a rise from a pretty long, awful spell of depression for me, and I've been afraid of the deeper recesses of my mind for a while. Still, pretty soon I should be able to make a report.
Warning: high theory ahead (my preferred waters) -- The reason I'm interested in low-dose LSD, specifically the effects I mentioned if I can maintain them, is I want to retain my creative edge. It's very important to me, as I want to work in a creative field. I don't think d-amp has suppressed my creativity overall -- especially with, apparently, nucleus accumbens dopaminergic effects mostly preserved via memantine -- and I get more work done, but I do seem to spend less time "stopping to think" and more time zoned-in. From my past experiences, I know that when the mood/motivation effect disappeared, this functional loss of creativity seems to worsen, which is in line with the typical rapid desensitization of response to the psychostimulant in the limbic system in favor of prefrontal stimulation, which can work forever in some people and which probably can antagonize limbic systems to a degree. Hence the "focus but zombification" that some people report in their negative response to psychostimulant therapy for ADD/ADHD. Apollonian/Dionysian, eh? I do associate my current inhibition with amphetamine's adrenergic effect which (helpfully, though, for anyone with attention or executive function issues) preferentially stimulates prefrontal structures ...
http://www.sciencedirect.com/scienc...serid=10&md5=9a8e04b8ed067dc003062591aac06c36
Besides LSD, I wonder if adding a couple of small doses of guanfacine to my regimen (as has been done with some ADHD children to offset cardiovascular side effects) would improve cognitive flexibility, without sacrificing the positive effects like mood, motivation, confidence, focus.
Memantine's partial antagonism and "fast blocker/unblocker kinetics", which in theory at the right dose should help to suppress excess NMDA transmission without compromising normal levels of functioning involved in learning and cognition, supposedly make it a pretty unique thing among NMDA antagonists. I may make a thread about my experiences with the drug here, soon.
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NoExpert
Bluelighter
My Dream Antidepressant.......
I would design a pill that would contain an extended release synthetic opiate, mixed with extended release amphetamine, maybe the active ingredients in Adderall(which I've never tried, but can imagine would be effective).
I think that combo would invigorate the depressed masses(myself included), and make most people more productive as well as give them some peace of mind.
But it would have to be monitored, to prevent abuse, and the dosages adjusted for each individual. I'd Maybe even manufacture these pills with differing ratios of active ingredients, to custom fit each person.
...to ...to 
...to :D ...to 
morphiquet
Bluelighter
the active ingredient in adderall is amfetamine.
Tsukasa
Bluelighter
My instant powdered anti-depressant formula for optimal levels of neurotransmitters and such:
LD phenylalanine - for tyrosine production and endorphin/phenethylamine breakdown inhibition
L-tryptophan & 5-htp - serotonin, niacin, melatonin, and other tryptamines
L-tyrosine & levodopa - catecholamines
L-glutamine - GABA, glutamate, & NMDA(?)
L-arginine - NO, HGH, glutamate, creatine, glutamate and other stuff
L-carnitine - acetylcholine, dopamine, and others
DMAE, choline, lecithin - Acetylcholine, myelin
Omega 3-6-9 - endocannabinoids, eicosanoids, lipoxins, and others
L-histidine - histamine & carnosine
Fenugreek & red raspberry leaves - to increase oxytocin levels
All essential vitamins and minerals
DHEA - steroid hormones
Glucose and Honey - as sweeteners and for adenosine production
Ginseng
Gingko biloba
Grapeseed or pine bark extract
Taurine
Cocoa powder - as flavoring and for psychoactive effects
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Tsukasa
Bluelighter
^ The carbohydrates though stimulate release of insulin. When this occurs, some amino acids that compete with tryptophan leave the bloodstream and enter muscle cells. This causes an increase in the relative concentration of tryptophan in the bloodstream.
but maybe I should omit the whey protein.
serotonin-system
Ex-Bluelighter
Tsukasa said:
Wouldn't most of those be present in excess in a healthy or even moderately healthy diet?
