any news on the new oxycontin?

[OxyRush]

hey if this is true, the new drug will be muchhh cheaper on the street and the docs will be prescribing it for even a papercut since it's "un-abuseable". People will be taking more since 10mg IR is equal to like 100mg ER. And Purdue or whoever will be happy because theyll make much more money.

 

[thestranger]

Does anyone know the timeline of when these changes might occur?

I hope when I get off probation (April) their are still regular OC's around

 

[rebo]

Ok, Deep breath for me………..I understand the difference between an active and an inactive. The best comparison I can make is Mini-Thins brand; original formulation with active ingredient of ephedrine hcl. Subsequently, under a different patent, Mini-Thins brand (no ‘version two’, or ‘beta’-the name remained exactly the same) pill contain an active list of ephedrine hcl, AND GUAFENESIN. No change to the name. In this case, there would be much more leeway anyway, as these are the generics to which I was referring. Simply oxycodone sustained release on the label.
That being said, since there were only 4 of us who had identical bioassay results (each of us dosed 3@ 20mg each, crushed, and just swallowed with water. Absolutely no effect was felt by any of us. It wasn’t simply the high that was absent, but the reduction of pain, and even constriction of pupils were simply never experienced. Two nights later, the same 4 of us each dosed 3@20 mg, INTACT. They came from the same bottle the previous ones did (and obviously same manufacturer), and the intact delivery system actually behaved the way that a 60 mg dose should. Now taking your feedback into account, I am finding it far less plausible that any manufacturer could add an antagonist to the drug, and actually gain approval from the FDA to market & sell under the same name (even if they will allow manufacturers to leave the gaaks off of the inactive lists every day), and won’t argue that point with you. I am however, still left with absolutely no insight as to why 4 of us all experienced identical differences (identical differences?) with the two delivery systems. I do not believe for a second that the lack of effects were all imagined, especially when the physical characteristics (pupils) factor in, but after more thought, would agree with you that actual narcan in the tablets is not the answer.

Oh, and Rocklobster, trust me, I don’t post bullshit info simply to post & feel important. You can feel free to pm me anytime you’d like to compare who has a more thorough grasp of the subject matter on this site. Like I said, I’ve only posted a few, so I can understand that you really don’t have many posts to base that statement on, but one suggestion would be to read some other info posted by the member before you decide to run your mouth about ‘lying’ in posts.

 

[mepat1111]

I agree with Rocklobster on this one, I snort OCs many times a week and I get very high off it. I do believe what you experienced is either tolerance, or placebo.

While I cannot post a source, I do remember reading a study where patients in a hospital who were on IV opiates (I believe it was either morphine or hydromorphone) for post-op or other strong pain were split into 3 groups. Group 1 was given a placebo, group 2 was given naloxone, group 3 was the control and continued to be given their pain killers. While the patients who were given the placebo did not exibit any signs of change, the group who were given naloxone experienced opiate WDs, and of course, pain.

Now what does this prove? That if there was naloxone in our OCs, we would definitely notice. Also as Rocklobster said, the pharmaceutical company would most definitely have to change the name of a product if they were to add another active. At bare minimum they would have to list it on the box, and I'm looking at a box of OCs right now and it does not list naloxone as an active ingredient.

 

[ktx49]

Ok, Deep breath for me………..I understand the difference between an active and an inactive. The best comparison I can make is Mini-Thins brand; original formulation with active ingredient of ephedrine hcl. Subsequently, under a different patent, Mini-Thins brand (no ‘version two’, or ‘beta’-the name remained exactly the same) pill contain an active list of ephedrine hcl, AND GUAFENESIN. No change to the name. In this case, there would be much more leeway anyway, as these are the generics to which I was referring. Simply oxycodone sustained release on the label.
That being said, since there were only 4 of us who had identical bioassay results (each of us dosed 3@ 20mg each, crushed, and just swallowed with water. Absolutely no effect was felt by any of us. It wasn’t simply the high that was absent, but the reduction of pain, and even constriction of pupils were simply never experienced. Two nights later, the same 4 of us each dosed 3@20 mg, INTACT. They came from the same bottle the previous ones did (and obviously same manufacturer), and the intact delivery system actually behaved the way that a 60 mg dose should. Now taking your feedback into account, I am finding it far less plausible that any manufacturer could add an antagonist to the drug, and actually gain approval from the FDA to market & sell under the same name (even if they will allow manufacturers to leave the gaaks off of the inactive lists every day), and won’t argue that point with you. I am however, still left with absolutely no insight as to why 4 of us all experienced identical differences (identical differences?) with the two delivery systems. I do not believe for a second that the lack of effects were all imagined, especially when the physical characteristics (pupils) factor in, but after more thought, would agree with you that actual narcan in the tablets is not the answer.

Oh, and Rocklobster, trust me, I don’t post bullshit info simply to post & feel important. You can feel free to pm me anytime you’d like to compare who has a more thorough grasp of the subject matter on this site. Like I said, I’ve only posted a few, so I can understand that you really don’t have many posts to base that statement on, but one suggestion would be to read some other info posted by the member before you decide to run your mouth about ‘lying’ in posts.

ok first, your comparing apples to oranges with the ephedra thing...ephedra can(or used) to be sold WITHOUT FDA approval....you could by the shit from a health store!!! sorry but pharmaceuticals go through a much different set of rules and guidlines. i could understand how you would make this comparison, but just understand that when ephedra was not banned, it was sold OTC at gas stations, health and herbal stores, GNCs, fitness stores, etc, etc, etc...you didnt neeed a prescription or FDA approval to buy or produce it.
this is certainly NOT the case with oxycodone; the active ingredient in OxyContin.

as far as FOUR people experiencing the same thing...all i can do is guess? maybe you had food on your stomach? maybe you were confused about tolerance levels? maybe you did not take it correctly(such as SNORTING a generic OC that is KNOWN TO GEL-UP & HINDER THE RELEASE OF THE OXY WHEN ABUSED). just as others said, if it were ANYTHING like an opiate antagonist, you would have been put into WITHDRAWAL; not just a lack of opiate high/effects.

my best guess, is that you tried snorting one of the generic brands and it gelled up on you trapping most of the oxycodone inside.
then when you took it as directed, it did not do this.
that or you guys all took it on full stomachs.

lmk, and again, i am NOT saying your lieing, but please be thruthful in your next response....i have a very VERY funny feeling you did one of the things i mentioned above...and im not trying to be rude, so sorry if i offended you.

let us know what happened and please again, be honest in your response about the failed experiene. did u snort it?

 

[hfrs]

Rebo- that is an extremely odd experience. In a few of your posts, you mention a bioassay, did you actally test these alleged oxycodone pills? What brand/manufacturer do you think you were taking? What country were the pills from?

At this point, the only approved drug (in the US) to contain an antagonist is suboxone. There are quite a few in trials and animal testing, but NO other formulations have been approved at this stage.

The patent I was talking about, way back, was a bead formulation (similar to kadian). The antagonist beads are identical to the agonist beads, they will not be able to be seperated by appearance. The difference comes in the actual composition of the bead. The antagonist containing beads will not dissolve significantly in the GI tract, the agonist beads will. If crushed, the antag beads will deliver 4 times the effective agonist dose (specific to the rx'd drug- i.e. one equivalent would nullify the agonist effects, the other 3 "extra" equivalents will make ya rethink crushing pills for awhile). It will be able to be used for any agonist, doesn't depend on its structure at all.

There are also other formulations in trials that intentionally deliver a small antagonist dose. There have been many studies showing that tiny antagonist doses potentiate full agonists as well as possibly decrease or at least slow the development of tolerance.

 

[yummy22]

...................

 

[johanneschimpo]

these aren't even out yet, and people are (trying to) find ways around them already.
god bless bluelight ingenuity.

 

[hfrs]

If this is true, couldn't you just put all the beads in water and let the goodies dissolve? Or would that not work?

No, at least not from what is known about them at this time. The polymer that makes up the bead is not water soluble and was designed to dissolve in "artificial gastric contents". When you lower the pH in an attempt to solubilize you would also start dissolving the antagonist. I have a few ideas on getting around it, but it's pretty pointless trying anything until the final formulation is finalized.

 

[redeemer]

these aren't even out yet, and people are (trying to) find ways around them already.
god bless bluelight ingenuity.

LOL, my thoughts exactly.

I don't think they'll ever develop pills containing a recreational drug that can't be abused somehow, peiod.

 

[ktx49]

^ i agree,

like these FUCKING mylan fentanyl patches...im never ever going to fill my script again until i know for a fact that the place ONLY carries the brand name or SANDOZ brand which both contain gel.

see MYLAN, you are already losing a ton of business you assholes. make a real fucking patch you stupid fucks.

following this scenario, you can see why OC brands that GEL like crazy are getting much less sales, and may eventually stop making them.
theres no point, the people who want to abuse them, will only get the brands they can abuse, and the people who dont abuse them do not NEED a anti-abusable medication as it makes no difference for them. its a lose-lose situation for the Pharmaceutical Companies making these stupid meds.

 

[rocklobster]

see MYLAN, you are already losing a ton of business you assholes. make a real fucking patch you stupid fucks.

You sure showed them. I'm certain they're ordering an OUT OF BUSINESS sign as we speak.

 

[ktx49]

^actually, consumer word means a lot and spreads pretty fast...

just think of the nearly 1,000 people who have viewed and read this thread...they might have seen my comments and now they will more than likely stay away from Mylan patches themselves and if anyone they know happens to use fentanyl they may tell them the same thing...

see?

it does make a difference but of course, i was being somewhat sarcastic

anyways to further prove my point, either a kroger or a publix near my place use to carry the TEVA brand oxycontins, but after like 7-8 months they quit carrying them "because we had so many complaints and problems!!!" straight from the pharmacists mouth and both of those chain stores are fairly big companies that could have brought alot of sales and revenue to TEVA if they had been as good as the watson ABGs or brand name OxyContins.

 

[rocklobster]

Yeah, go ahead and bankrup Mylan, Mr. Consumer. You have the (consumer) power! Go go shitty junky.

 

[lyserg]

Rocklobster, just shut up. Quit all the mean, sarcastic comments. Honestly, if your not going to provide any useful imformation to this forum do not post.

 

[rocklobster]

I provide plenty of information.

 

[pokergooch]

Purdue WAS going to produce this "Smart pill" The program got shelved right after they started to produce it because of ill-effects. They said that they would have to start from scratch. I get the 80s from them every month and while my doc said that they were going to put nalaxolone in it a couple of years ago, theve decided against it..

PG

 

[johnnyb420]

in related news my pharmicist confirmed that generic versions of oxycontin will not be available any more because purdue won patent protection litigation finally

 

[sixpartseven]

^ i dont know if youre being serious or not. are you?

 

[the unknown]

in related news my pharmicist confirmed that generic versions of oxycontin will not be available any more because purdue won patent protection litigation finally

This IS true. I have the article.

Generic oxycontin will no longer be availiable and only Purdue Pharma will be offering the pill. They won. We lost.