Just a note on vasoconstriction, I will note that I have certainly experienced slight vasoconstriction from both 25i and 25c NBOMe in many experiences with both. It doesn't always happen, or rather not in a noticeable way, but if you feel it once in your life you know what to look for if it happens again. (BTW my usual dose for both is 1mg and 800ug for the 25i and 25c respectively, although I have dipped into dosages as high as 2mg and 1.2mg respectively.)
With both instances of the higher doses, there was little noticeable vasoconstriction, however with many of my lower-dosed trips there was certainly vasoconstriction which, for me, is most commonly felt in my legs. However, there's only been one instance (In which I combined 800ugof 25c-NBOMe and 1mg of 25i-NBOMe) where it has gotten to the point where it was so uncomfortable that I needed to relieve it by smoking weed (vasodilator) and by soaking my legs in a hot-tub.
This proved effective, but the sensation returned an hour later in a much lighter, and less uncomfortable fashion and then receded after about 45min. I'm not sure the exact reason for why the vasoconstriction was so exadgerated in this experiment, but I have sort of attributed it to drug synergy.
I would caution that combo though. While it was a great experience overall, the vasoconstriciton is always a scary thing when you know whats happening to you and you're really really high. It never reached the point of being "painful" per say, but it was most deffinatly uncomfortable and certainly affected the trip, which had been a bike ride that had to come short due to my discomfort in my legs and knowing that the spa at home would relieve it.
I havent tried the combo since due to this encounter with vasoconstriction, but will eventually at a lower dosage. Just thought id give that 2 cents. Its a great combo and worthwhile, but dose low, and be sure to be WELL experienced with both 25i and 25c in their own right before hand, meaning both their highs and their physical effects on your body. The combo will kick your ass relelntlessly otherwise lol, both physically and mentally.
EDIT: (BTW all doses are sublingual ROA)
With both instances of the higher doses, there was little noticeable vasoconstriction, however with many of my lower-dosed trips there was certainly vasoconstriction which, for me, is most commonly felt in my legs. However, there's only been one instance (In which I combined 800ugof 25c-NBOMe and 1mg of 25i-NBOMe) where it has gotten to the point where it was so uncomfortable that I needed to relieve it by smoking weed (vasodilator) and by soaking my legs in a hot-tub.
This proved effective, but the sensation returned an hour later in a much lighter, and less uncomfortable fashion and then receded after about 45min. I'm not sure the exact reason for why the vasoconstriction was so exadgerated in this experiment, but I have sort of attributed it to drug synergy.
I would caution that combo though. While it was a great experience overall, the vasoconstriciton is always a scary thing when you know whats happening to you and you're really really high. It never reached the point of being "painful" per say, but it was most deffinatly uncomfortable and certainly affected the trip, which had been a bike ride that had to come short due to my discomfort in my legs and knowing that the spa at home would relieve it.
I havent tried the combo since due to this encounter with vasoconstriction, but will eventually at a lower dosage. Just thought id give that 2 cents. Its a great combo and worthwhile, but dose low, and be sure to be WELL experienced with both 25i and 25c in their own right before hand, meaning both their highs and their physical effects on your body. The combo will kick your ass relelntlessly otherwise lol, both physically and mentally.
EDIT: (BTW all doses are sublingual ROA)
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