Don't be sorry to ask questions
I don't really trust them because:
- I had two experiences with 25X-NBOMe compounds namely the 25C and 25D, at low doses (around 300 ug) and got extremely cold feet with the 25D that prevented me from relaxing and enjoying the effects. I was not really worried but it preoccupied me. Generally I found the effects of both interesting and worthwhile but vasoconstriction puts me off and I would want to go higher to experience the trip better and that might not be possible if this keeps happening to my feet.
- Some people are tolerant of much higher doses than others, sensitive people can suffer dangerous complications if they take too much. DOX compounds for example which can also be dangerous, are also potent, but they don't seem as unpredictable and getting a dose absorbed reliably is not such a hassle with them.
Some people experience little or no side effects while others get weird stuff like sweating buckets, overheating or fluctuation body temperature, jitters, and I'm sure I read of quite a few more that make me wonder what is up with that (though involvement of serotonin mediated brain functions seems somewhat evident)... and I don't appreciate not understanding that better.
- A number of them are full agonists at the 5-HT2A receptor. While I don't avoid all full agonists like the plague in practice (I have taken AM-2201 now and then, but discontinued), I'd like to use them as little as possible. Just like with cannabinoids full agonists appear to be able to cause long-term effects much more quickly than partial agonists. For cannabinoids this means it seems easier to get tolerance and withdrawals with relatively less use. Now some threads are popping up with people getting tolerance and even withdrawal symptoms with these serotonergics the latter of which is quite unheard of with this class of drugs.
IMO clearly the ultra potent nature of these compounds make their potential consequences more severe, at least there are indications for this. History of use is so short that there can be problems with NBOMe's that we have yet to fully realize.
I don't mean to make premature claims and I don't want to get the whole forum in an uproar because of my own concerns based on speculation, but deciding for myself I find all of this pretty disturbing.
I might sample NBOMe compounds again with apprehension, probably 25I which sounds like one of the most popular ones, to see if I keep having the vasoconstriction effects or if there are signs that it is mostly messing with bodily sensations... and I will not take them intranasally again, maybe that helps too.