FYI, Methoxetamine
I'd like to report some odd experiences, regarding the apparent bio-availability of methoxetamine. Some threads I tried to start, in another section of the forums, about how to make it into gel tabs, were closed; but, in case any non-fascists want to know how trials went, I'd like to relay observations.
Approximately 500mg of methoxetamine was administered over the course of 24 hours, in the form of bulky, pectin-based gel. Results were similar to prior experiences with roughly 200mg, administered over the course of a day, by repeatedly placing small doses of powder under the tongue.
I have two conjectures about this lack of effects. Sub-lingual administration may impart far greater bio-availability than swallowing (which likely occurred, by accident, because the gel was very bulky), due to interference of gastric enzymes. Alternatively, enzymatic levels may have changed rapidly, and caused accelerated excretion from the body. Prior trials, for years, of frequently administering small doses of DXM, convince me that the tolerance (assuming that bio-availability was irrelevant) was not due to regulation of receptor density; because chronic use of DXM did not impart comparable tolerance.