the toad
Bluelighter
I find that it has to be morethan coincidence that many peoples lives get that kickstart they need right after their brush with mxe 
The Big & Dandy Methoxetamine Thread - 5th Dose (you took too much, seriously)
- Thread starter any major dude
- Start date
- Status
boiledfruit
Bluelighter
I find that it has to be morethan coincidence that many peoples lives get that kickstart they need right after their brush with mxe
Quite. I find this compound more useful for this sort of thing than all of the synthetic psychedelics I have tried, albiet far stranger.
SpecialK_
Bluelighter
- Joined
- Mar 11, 2010
- Messages
- 3,531
Be VERY careful with this. This is exactly how many people who find themselves addicted to dissociatives begin to enjoy them at first, I have experienced that 'euphoric' feeling the day after taking MXE and to be honest I would still consider myself under the influence of it while I'm feeling these effects.
Limitbreaker
Bluelighter
- Joined
- May 13, 2011
- Messages
- 487
Wow. I can't wait to try it out. I've never really tried to go to a doctor to diagnose the depression, cause I'm afraid it could be my own imagination creating depression and binding it to me, as the reason to how I fail at life. I feel empty and lack motivation hard. Not many things seem enjoyable to me. This was long, long before I've started using drugs so it isn't the reason. I've recently bought 2 grams and wondering what doses are best for AD effect.
Please do not take off this topic and don't move it to Ketamine as AD discussion.
Thanks and good luck to you too!
Please do not take off this topic and don't move it to Ketamine as AD discussion.
Thanks and good luck to you too!
yucatanboy2
Bluelighter
If you are interested in continuing using MXE for depression, definitely read the thread that Jamshyd put together on Ketamine regimen for antidepressant use:
http://www.bluelight.ru/vb/threads/...2-10)?highlight=Ketamine+antidepressant+guide
Also, cut out the MDPV use, that's not gonna help you. Its just going to mess up your BP/seratonin/dopamine more, and you may just be feeling good because you are in an amphetamine-induced euphoric psychosis.
If you continue using MXE for antidepressant effects, definitely use well below the recreational use, I would cut it down to 5-10mg a few times a day TOPS. Again, see Jamshyd's work (I noticed one reply that said they used MXE successfully that way too).
NOTE: this is a very very very thin line to walk between medicinal use and abuse. You have to be very very very very very strong-willed to keep it in the proper regime.
http://www.bluelight.ru/vb/threads/...2-10)?highlight=Ketamine+antidepressant+guide
Also, cut out the MDPV use, that's not gonna help you. Its just going to mess up your BP/seratonin/dopamine more, and you may just be feeling good because you are in an amphetamine-induced euphoric psychosis.
If you continue using MXE for antidepressant effects, definitely use well below the recreational use, I would cut it down to 5-10mg a few times a day TOPS. Again, see Jamshyd's work (I noticed one reply that said they used MXE successfully that way too).
NOTE: this is a very very very thin line to walk between medicinal use and abuse. You have to be very very very very very strong-willed to keep it in the proper regime.
Limitbreaker
Bluelighter
- Joined
- May 13, 2011
- Messages
- 487
What about MXE' influence on kidneys?
the toad
Bluelighter
Were calling it K squared... (we = my friends and myself) the exponetial K...
incognition
Bluelighter
Personally i don't belive in this low dosing against depression. Thats just something temporary. No, what you need is ONE proper full blown reset and you'll be fine for 2-3 weeks. Deep, deep hole-dose. Repeated dosing can have opposite effect.
the toad
Bluelighter
^ I agree
helium-4
Bluelight Crew
the problem with that is there are more side-effects from high dose dissociative use than low dose use (based on ketamine and other psychoactive NMDA antagonist studies). It would be better to use multiple low dose than large doses here and there to prevent negative effects on the creation of new behaviors, memories (spatial included), long term potentation of NMDA receptors etc. during and after use. For someone who has daily life obligations that could become an annoying consequence of using it as tool for therapy. Not to mention, the inherent problem with associating medication with recreational effects. Though an interesting fact, previous behaviors, memories, and LTP are not disturbed. If one can get rid of the disruptions, more benefits begin to show with NMDA antagonists, like the ability to decrease the decay of LTP after induced, longer retention of memories, etc. If there is a period where one does not create new memories actively very well, doesn't induce LTPs, and what not, the ability of the NMDA antagonist to prevent decay of LTP induction, and late phase LTP protein synthesis, as well as enhancing memory retention decreases.
Wouldn't someone want the benefits of daily, or few times a week use of low dose nmda-antagonism to help create better behaviors, reinforce memory functioning, and brain health during a period where a anti-depressant would play a legitimate therapeutic role?
Wouldn't someone want the benefits of daily, or few times a week use of low dose nmda-antagonism to help create better behaviors, reinforce memory functioning, and brain health during a period where a anti-depressant would play a legitimate therapeutic role?
Marauder
Bluelighter
THIS REPLY IS TO MY "MXE AS AN ANTIDEPRESSANT = VERY EFFECTIVE" ORIGINAL POST WHICH HAS BEEN MOVED:
SCROLL UP THIS THREAD TO SEE OP.
i was drafting a long reply esp addressing the MDPV and its devilish nature (no longer using) and addressing a lot of your concerns. instead of procrastinating on that and leaving you guys in the dark, I will post my personal notes from the weekend, as-is:
SCROLL UP THIS THREAD TO SEE OP.
i was drafting a long reply esp addressing the MDPV and its devilish nature (no longer using) and addressing a lot of your concerns. instead of procrastinating on that and leaving you guys in the dark, I will post my personal notes from the weekend, as-is:
Xamkou
Bluelighter
Great read that!! ^
-
A problem I have with this substance is that with high doses (100mg+ nasally) I tend to get up and search my house for a family member whom I proceed to sit with and babble on with my anesthetized lips. Needless to say, it doesn't make them happy. I have no recollection of this, ever.
-
A problem I have with this substance is that with high doses (100mg+ nasally) I tend to get up and search my house for a family member whom I proceed to sit with and babble on with my anesthetized lips. Needless to say, it doesn't make them happy. I have no recollection of this, ever.
cosmic._.ape
Bluelighter
|
Taking mxe is worthless if you don’t act on the visions or epiphanies that you might get from it. If I had not followed what those experiences suggested me to do, if I were living the same live that I was living before I had mxe, I would still be depressed right now. I would still feel like if I was wasting my life and, sooner of later, mxe would stop giving me any kind of satisfaction.
and that’s the hard part of it. To act your dreams
It’s, of course, obviously, very easy to have some mxe and receive fantastic visions and epiphanies about how to live your live. But to turn those visions into a real life mission is harder and more difficult. it includes the most obvious basic stuff of taking care of yourself (good diet, exercise (including some sort of “mental” exercise, i.e. a type of yoga, meditation, tai chi whatever, something like that –it can simply be to focus your attention in what you perceive instead of what you think (that’s my favourite type of "mental training", as it’s simple and I’m lazy), enough sleep, doing something that is useful to others to give some meaning to your life…) plus lots of research to find a practical way to turn your dreams into your actual life. The *how to*. Nothing new I know.
But I don’t think it could be done otherwise. To wish it is nothing more than the first step.
Imo, if you are lucky, mxe can work as kind of alchemical personal life-trainer. the most valuable trait of mxe could be that it can give you the necessary confidence to try to achieve your dreams.
But it can't do it for you
Taking mxe is worthless if you don’t act on the visions or epiphanies that you might get from it. If I had not followed what those experiences suggested me to do, if I were living the same live that I was living before I had mxe, I would still be depressed right now. I would still feel like if I was wasting my life and, sooner of later, mxe would stop giving me any kind of satisfaction.
and that’s the hard part of it. To act your dreams
It’s, of course, obviously, very easy to have some mxe and receive fantastic visions and epiphanies about how to live your live. But to turn those visions into a real life mission is harder and more difficult. it includes the most obvious basic stuff of taking care of yourself (good diet, exercise (including some sort of “mental” exercise, i.e. a type of yoga, meditation, tai chi whatever, something like that –it can simply be to focus your attention in what you perceive instead of what you think (that’s my favourite type of "mental training", as it’s simple and I’m lazy), enough sleep, doing something that is useful to others to give some meaning to your life…) plus lots of research to find a practical way to turn your dreams into your actual life. The *how to*. Nothing new I know.
But I don’t think it could be done otherwise. To wish it is nothing more than the first step.
Imo, if you are lucky, mxe can work as kind of alchemical personal life-trainer. the most valuable trait of mxe could be that it can give you the necessary confidence to try to achieve your dreams.
But it can't do it for you
the toad
Bluelighter
^ very well said...
helium-4
Bluelight Crew
You gotta be careful with the use/interpretation of dissociated (or any psychedelic) visions or epiphanies. Of course psychotherapy aided with psychoactive substances has it's place, but the resulting mind states can skew peoples lives negatively. Dissociatives can lead people to delusional, dissociated behaviors/states of mind, and anti-social behavior, which isn't as easily resolved like the cognitive impairments seen with dissociative drugs (cognitive impairments disappear after use, but dosage and duration of use alters the period of recovery from these issue). Even extremely intellectual minds like John Lilly and many graduates from prestigious universities can fall victim to the psychological changes resulting from use of these substances. It is easy to get drawn into the world created and the visions/epiphanies associated with the experience, potentially resulting in a psychological addiction that can be transparent to the user. Dissociative are generally seen to be with out physical signs of addiction, making it hard to see the psychological addiction forming for them. People with underlying issues, or psychological problems in general are more prone to the potential of addiction, especially when they are using a substance to self medicate. The philosophies extrapolated from these dissociative experiences must be approached with care, as there can be a risk of collusion with the maladaptive beliefs of persons suffering of mental illnesses. With chronic use, levels/frequency of depression with in users can actually increase compared to non-dissociative user as well (studies did note that these users were more likely to be using other drugs in addition to the chronic ketamine use, and drug abuse isn't beneficial for depression).
It is easy to deny the potential of one self to fall into such issues, but dissociatives are not like your traditional psychedelics. They don't have that self-limiting aspect, and with the therapeutic potentials for relief from anxiety, depression, etc. it can be easy for one to fall into such issues. I'll admit I had a naive view of the potential psychological and cognitive impairments that can result from dissociative use for a while, but like you I would like to benefit from the potential therapeutic aspects of dissociatives, so I like to understand the risks.
I'm not saying large dose dissociatives wouldn't be beneficial as there are studies finding them to be very helpful for different therapies, but if the intent is to use them for therapeutic purposes generally one would want minimal impairments in other areas during the period of treatment. Cellular changes within the brain accompany behavior modification, memory formation, retention, and recall, and alteration in learning. Mass antagonism of NDMAr's can alter the cellular changes during and post use, causing latent inhibition. When one is trying to learn new behaviors to overcome the psychological problem, it wouldn't be in the best there best interest to reduce their capability for such formation. Also seen with ketamine, cellular changes can become altered to have benefits on memory formation, retention, and recall by preventing the decay of early and late phase decay of LTP, which require antagonism at different points in time after initiation of the LTP.
I don't really know the whole mechanism behind the resulting anti-depressent effects of the activation of mTOR, but through the cascade of effects, and multiple stages of the mechanism to produce enough products of transcription factors to alter phenotypes of the cells, prolonged antagonism of NDMAr's helps create an improved stable neural homeostasis. Theoretically this should create a longer lasting period of anti-depressant effects, rather than that created by short bursts of the cascade resulting in the mTOR.
I dunno, based on what I've read, it seems like smaller doses, taken frequently can reduce psychotropic effects that can interfere with daily functioning and cause cognitive defects, produce cognitive enhancing effects and stable neural homeostasis through alteration of cellular processes in a positive way. Some studies with ketamine I've recently looked at have even shown minor amounts of impairments of working memory (but really isolated to ketamines duration when the minor impairment was seen, in the studies that showed enough to report it), so timing of the dose could be important to also minimize any impairment even for small doses. Maybe taken first thing in the morning at least an hour to an hour and a half before your daily routine (job, school, studying, etc.), or at night would be the most beneficial time to dose. Any memories created before ingestion of ketamine still remains unaltered even with working memory impairment (seen with low dose and high doses of recreational levels), with the potential for an increase in retention and recall. Translating this to MXE, it may have a longer period of slight impairment at low doses due to its duration, so maybe wise to dose at night.
Acute administration of recreational levels of ketamine has showed impairment of working memory during the experience, declining till roughly 24 hours or so, with three days post ingestion to be sufficient enough time to show no impairment of working memory. The more frequently the administration the longer lasting the impairment becomes, but upon cessation of near chronic or chronic use the impairment disappears over time. Psychological effects like delusional ideation and dissociative symptoms were slower to disappear. So care should be taken when dosing higher to not interfer with important tasks post use, like tests for school, important tasks at work.
It is easy to deny the potential of one self to fall into such issues, but dissociatives are not like your traditional psychedelics. They don't have that self-limiting aspect, and with the therapeutic potentials for relief from anxiety, depression, etc. it can be easy for one to fall into such issues. I'll admit I had a naive view of the potential psychological and cognitive impairments that can result from dissociative use for a while, but like you I would like to benefit from the potential therapeutic aspects of dissociatives, so I like to understand the risks.
I'm not saying large dose dissociatives wouldn't be beneficial as there are studies finding them to be very helpful for different therapies, but if the intent is to use them for therapeutic purposes generally one would want minimal impairments in other areas during the period of treatment. Cellular changes within the brain accompany behavior modification, memory formation, retention, and recall, and alteration in learning. Mass antagonism of NDMAr's can alter the cellular changes during and post use, causing latent inhibition. When one is trying to learn new behaviors to overcome the psychological problem, it wouldn't be in the best there best interest to reduce their capability for such formation. Also seen with ketamine, cellular changes can become altered to have benefits on memory formation, retention, and recall by preventing the decay of early and late phase decay of LTP, which require antagonism at different points in time after initiation of the LTP.
I don't really know the whole mechanism behind the resulting anti-depressent effects of the activation of mTOR, but through the cascade of effects, and multiple stages of the mechanism to produce enough products of transcription factors to alter phenotypes of the cells, prolonged antagonism of NDMAr's helps create an improved stable neural homeostasis. Theoretically this should create a longer lasting period of anti-depressant effects, rather than that created by short bursts of the cascade resulting in the mTOR.
I dunno, based on what I've read, it seems like smaller doses, taken frequently can reduce psychotropic effects that can interfere with daily functioning and cause cognitive defects, produce cognitive enhancing effects and stable neural homeostasis through alteration of cellular processes in a positive way. Some studies with ketamine I've recently looked at have even shown minor amounts of impairments of working memory (but really isolated to ketamines duration when the minor impairment was seen, in the studies that showed enough to report it), so timing of the dose could be important to also minimize any impairment even for small doses. Maybe taken first thing in the morning at least an hour to an hour and a half before your daily routine (job, school, studying, etc.), or at night would be the most beneficial time to dose. Any memories created before ingestion of ketamine still remains unaltered even with working memory impairment (seen with low dose and high doses of recreational levels), with the potential for an increase in retention and recall. Translating this to MXE, it may have a longer period of slight impairment at low doses due to its duration, so maybe wise to dose at night.
Acute administration of recreational levels of ketamine has showed impairment of working memory during the experience, declining till roughly 24 hours or so, with three days post ingestion to be sufficient enough time to show no impairment of working memory. The more frequently the administration the longer lasting the impairment becomes, but upon cessation of near chronic or chronic use the impairment disappears over time. Psychological effects like delusional ideation and dissociative symptoms were slower to disappear. So care should be taken when dosing higher to not interfer with important tasks post use, like tests for school, important tasks at work.
Last edited:
the toad
Bluelighter
After putting some thought into it I want to say that mxe is like K's high strung supercharged cousin lol... sound about right?
Sorta off topic:
whilst on mxe i've come to conclusion, dissociatives are not the so-called "death" when contrasting against psychedelics ideology of "birth". Dissociatives are Pre-Birth.... you are in the womb. Man am i whacked out on mxe
And indian music (especially from the movie "The Guru") sounds awesome!
----
I will say that the rate at which delusions come into play with this substance is quite discomforting for me. I can see myself and many others losing their minds!
I wish to get rid of the delusional thoughts/mannerisms of this drug, but the only way to do that is to quit... so difficult. My only suggestion to others is limit your dosage and binging. Valium is only a band-aid
Also, remember the old saying "If it's too good to be true..." Don't fall prey to your own thoughts.
*on 80mg mxe*
whilst on mxe i've come to conclusion, dissociatives are not the so-called "death" when contrasting against psychedelics ideology of "birth". Dissociatives are Pre-Birth.... you are in the womb. Man am i whacked out on mxe
And indian music (especially from the movie "The Guru") sounds awesome!
----
I will say that the rate at which delusions come into play with this substance is quite discomforting for me. I can see myself and many others losing their minds!
I wish to get rid of the delusional thoughts/mannerisms of this drug, but the only way to do that is to quit... so difficult. My only suggestion to others is limit your dosage and binging. Valium is only a band-aid
Also, remember the old saying "If it's too good to be true..." Don't fall prey to your own thoughts.*on 80mg mxe*
Last edited:
Xamkou
Bluelighter
I haven't had an addictive streak like this since I first began using Mephedrone in 2009. I actually get giddy at college or work knowing that when I get home, I can rail about 120mg and I know I'm in for an amazing 6-7 hours (what I did about 20 mins ago). Intense euphoria is blossoming once again, what a magical substance. I love how amazing large LCD TVs are to watch in the dark when really fucked on Methoxetamine too, has anyone else noticed that?!
The scary thing about this substance is that there is no hangover. With Mephedrone, I feel like shit the next day and I wait a week or two in order to full the full force of the euphoria and empathy Mephedrone has to offer. With this, it's quite the opposite. I go into work and college with a massive smile on my face and get everybody in good moods only to come home and rail a line again. The start of mania?
Feeling like I'm running in circles. Though I did beat my Mephedrone addiction (I use it responsibly now), I reckon I'll be attempting to beat a Methoxetamine addiction before long. Weird thing is, the need for Methoxetamine doesn't feel at all sinister, whereas, at times, Mephedrone overuse can feel sinister.
And on that note, I'm off to play on clouds. Happy Mx'ing!
The scary thing about this substance is that there is no hangover. With Mephedrone, I feel like shit the next day and I wait a week or two in order to full the full force of the euphoria and empathy Mephedrone has to offer. With this, it's quite the opposite. I go into work and college with a massive smile on my face and get everybody in good moods only to come home and rail a line again. The start of mania?
Feeling like I'm running in circles. Though I did beat my Mephedrone addiction (I use it responsibly now), I reckon I'll be attempting to beat a Methoxetamine addiction before long. Weird thing is, the need for Methoxetamine doesn't feel at all sinister, whereas, at times, Mephedrone overuse can feel sinister.
And on that note, I'm off to play on clouds. Happy Mx'ing!
- Status