The Big & Dandy Methoxetamine(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) Thread
- Thread starter Treatderek
- Start date
- Status
Opiyumphile
Bluelighter
- Joined
- Jul 21, 2009
- Messages
- 61
It's now the day after my fifth time researching with MXE and this is the first time I noticed some kidney pains and stomach discomfort.
There has been at least three or four days in between each of the five doses and the same goes for this most recent time.
It's not overwhelming but it is annoying.
There has been at least three or four days in between each of the five doses and the same goes for this most recent time.
It's not overwhelming but it is annoying.
Same here. I've had 5 or 6 sessions over the past 3 weeks. Last one was on Sunday and I woke up an annoying ache in my lower stomach. It's not painful as such, I just know it's there constantly.
So does this normally stop when comparing it to Ket stomach "pains"?
I'd be slightly wary of this RC.
Last edited:
incognition
Bluelighter
I had a friend here over christmas for a few days and we did a fair bit of MXE, for two consecutive days. The day after our last journey we got sick from stomach flu in the house. We were 11 ppl here (8 got sick), but only me and the friend had done MXE. My friend developed severe stomach cramps after a few hours of plain stomach flu symptoms and had kidney pains, it got so bad i took him to the hospital on his request.
They did all sorts of tests but nothing came out unnormal, kidneys OK and all. They gave him spasmofen for the cramps and sugar/salts drip (he was dehydrated from the stomach flu) and he was ok in an hour or two and we drove back home.
I have no clue if it was related to MXE, but i could not stop thinking of ketamine cramps when i saw him. The doctors also found it strange with his sore kidneys and extreme pains. We didn't tell about the prior MXE-use since i have neighbor who works as a nurse there, and it seemed unnecessary.
I dont like to say this, but for the record - he's kind of a pussy when it comes to certain things. Sensitive would be the word i would use if i had to be polite.
Just wanted to let y'all know.
Last edited:
I've never had the pains stay around for long, but keep in mind i drink a hell of a lot of water anyway. The only 'annoying' side effect I've had from MXE is abit of like motion feelings in my face, aswell as having a totally numb head for a few days after. More distracting than annoying to be honest.
growit&smokeit
Bluelighter
About two weeks ago I did around 24mg over the space of three hours. The experience was nothing special to be honest and I would say I enjoyed it less than doing DXM.
I noticed for about a week after I experienced the lower back aches. They are in the vicinity of the kidneys but it seemed like it was a muscle ache as well. it wasn't too severe more anoying and worrying. It reminded me of the aches you get after a heavy night on the booze. I can remember reading I think from f&B that it was hepatoxic. So it could be a liver thing. Quite scary to be honest.
I noticed for about a week after I experienced the lower back aches. They are in the vicinity of the kidneys but it seemed like it was a muscle ache as well. it wasn't too severe more anoying and worrying. It reminded me of the aches you get after a heavy night on the booze. I can remember reading I think from f&B that it was hepatoxic. So it could be a liver thing. Quite scary to be honest.
I haven't read most of this thread, but have we come to any kind of consensus on ROAs?
Obviously pinning or insulfating are the way to go, but what if you don't do needles and your nose is blocked to fuck?
Seems that orals no good, but some peeps were saying sub lingual worked as well as earlier on in the thread.
What about plugging, this usually works well as an alternative for IM and insulfation, but haven't heard much talk about it. If it works but just not as well as up the nose, it might be worth trying. How does the dosage range compare to snorting?
Had this before, straight up the nose and had a really great time. Don't want tonight's experience to ruined by choosing the wrong roa.
I've always wondered to what extent the level of catarrh present ect. in the nasal cavity affects absorption rates. Anyone like to comment? If I can breath through it, is it good enough to snort through it?
Cheers
Obviously pinning or insulfating are the way to go, but what if you don't do needles and your nose is blocked to fuck?
Seems that orals no good, but some peeps were saying sub lingual worked as well as earlier on in the thread.
What about plugging, this usually works well as an alternative for IM and insulfation, but haven't heard much talk about it. If it works but just not as well as up the nose, it might be worth trying. How does the dosage range compare to snorting?
Had this before, straight up the nose and had a really great time. Don't want tonight's experience to ruined by choosing the wrong roa.
I've always wondered to what extent the level of catarrh present ect. in the nasal cavity affects absorption rates. Anyone like to comment? If I can breath through it, is it good enough to snort through it?
Cheers
killermunchies
Bluelighter
- Joined
- Jul 9, 2010
- Messages
- 552
incognition
Bluelighter
In your case it must be mental or related to something else. 24 mg? Come on. No surprice the experience was nothing special.
I've dosed doses between 100 and 200 mg several days in a row, and haven't noticed a thing. I guess it's irritating the bladder and kidneys just like ketamine. Some ppl are more sensitive than others.
No needles for me. What's the best way to get the powder under your tongue, tip it there using a folded piece of paper or just the good old fashioned licked finger?
<edit> how long should it take to fully absorb into the bloodstream?
growit&smokeit
Bluelighter
^
Yeah it had occurred to me it was pychosomatic. I had read of others experiencing lower back pains before taking it. I have only my subjective view of the pain so it is hard to tell. I did a lot of nitrous (56) and weed as well so it might of been that ;-)
It was my first time taking it so I was very conservative with dosing. I may do it again in future but as it was, for me, less fun than 150mg DXM with the unknown risk associated with being a RC it may be some time.
Yeah it had occurred to me it was pychosomatic. I had read of others experiencing lower back pains before taking it. I have only my subjective view of the pain so it is hard to tell. I did a lot of nitrous (56) and weed as well so it might of been that ;-)
It was my first time taking it so I was very conservative with dosing. I may do it again in future but as it was, for me, less fun than 150mg DXM with the unknown risk associated with being a RC it may be some time.
having been following this thread for some time... I think there is a growing acknowledgement of lower back pain/muscle spasms/kidneys/bladder related something along those lines. I myself have experienced it for over 2 weeks after MXE dosing... I'm still getting it actually, but it's manageable now, it is clearly related to it's use... it is hard to say how severe the problem is, I had a simple kidney urine test and it was fine, also the pains do die down over time... they also come back if you do MXE again.. they come back if you do other drugs again, MDAI caused the sensation, even a modafinil brought it back, I don't want to give the impression that I'm taking chemicals all the time, my usage has been conservative, but I have had some MXE sessions which high doses... I believe we're dealing with a kind of lasting irritation or perhaps as others have said, a metabolite lingering around, hopefully not permanent harm... I'm not sure if this is dose related, purity related (I got it from both batches), perhaps it's something related to physical hallucinations that you get on high MXE doses, because sometimes it feels more like a muscle spasm than an internal issue. Whatever, people do need to acknowledge it as a real problem because the aches are quite severe, seem to last a long time... I've taken 2 week gaps and the pains came back unfortunately which sucks.. kratom helped actually as a pain killer, gonna have to stay away from MXE for much longer tho, I won't touch it again until I'm 100% as it seems to aggravate the problem, it's been 2 weeks and I have an ache still.
growit&smokeit
Bluelighter
It is interesting you mention the muscle spasm thing as it most resembles a muscle ache usually. I too am not going to do it again untill it is more established, to be honest I doubt I will do it again. I wonder if there is an age component to it, if it is a liver issue it could be the older you are the more supcetible you are to having problems due to damage caused by drinking.
Last edited:
incognition
Bluelighter
What's a high dose for you? How frequently did you use? Do you drink plenty of water?
I find it so strange i can use it so heavily without noticing anything. But i do drink a lot of water. Always a litre or two during a session.
amanitadine
Bluelighter
It is likely methoxetamine is N-dealkylated and produces a metabolite structurally similar to "norketamine". This is what is speculated to be the culprit in the ulcerative cystitis of the bladder that has popped up in heavy ketamine users. It is still a relatively rare phenomenon (chronic use of a gram or so a day common but not required), but is indeed measurable, with a thickening of the bladder wall, and irritation of the lining and such. Cessation of ketamine, de-acidification of the urine, and drinking lots of water usually clears it up but often more treatment is required and there has been permanent damage I believe.
However, I think a lot of this is probably psychosomatic, esp in regards to methoxetamine. Not saying it ain't happening, but i would be really surprised if a dose or two of MXE would cause notable irritation and pains, seeing as how it is likely metabolized in a similar fashion to ketamine, the dose is much smaller, and how (usually) it takes daily long term use of mammoth doses of ketamine to get there.
I would suggest drinking lots of water. ( a good habit to get into regardless! I would feel like ass without at least +3000ml a day) I have noticed methoxetamine is a bit of a diuretic, but I haven't gotten any bladder or kidney pains. But I didn't from ketamine either, and I was a very heavy user for a long time.
Cheers
However, I think a lot of this is probably psychosomatic, esp in regards to methoxetamine. Not saying it ain't happening, but i would be really surprised if a dose or two of MXE would cause notable irritation and pains, seeing as how it is likely metabolized in a similar fashion to ketamine, the dose is much smaller, and how (usually) it takes daily long term use of mammoth doses of ketamine to get there.
I would suggest drinking lots of water. ( a good habit to get into regardless! I would feel like ass without at least +3000ml a day) I have noticed methoxetamine is a bit of a diuretic, but I haven't gotten any bladder or kidney pains. But I didn't from ketamine either, and I was a very heavy user for a long time.
Cheers
Treatderek
Bluelighter
- Joined
- Feb 12, 2010
- Messages
- 59
OP here 
my this thread has grown! Finally bought some methoxetamine and plan to sample this weekend, looks like a good'n :D
my this thread has grown! Finally bought some methoxetamine and plan to sample this weekend, looks like a good'n :DNever went over 150mg in an evening...I've been posting in this thread since early days, and I was a big advocate, there were weekends when I did it twice, but I doubt I did more than 250mg in a weekend... once every 2 weeks... first week did it about 4 times but that was a long time ago... I hardly drink alcohol and I was drinking loads of water... I drink loads of water+ I'm very sensible in general... this doesn't really seem to make a difference.
amanitadine - is it possible that methoxetamine is creating more of the metabolite? to me it's more likely that it is something else entirely, because it is happening and it's obviously been happening to a few people on this thread. There is not a chance of it being psychosomatic because I had these problems long before I read any other accounts of it (all the way back to the first week of batch1) and I didn't even know about ketamine ulcerative cystitis. Plus I'm just not that way inclined, and I'm as surprised as anyone by the problem. I obviously have not done huge amounts of it, like you'd need to do damage with ketamine and I believe the guy who got the pains from 25mg, I would reconsider what is happening.
I think people want MXE to be completely safe, but I think people would be foolish to disregard these accounts. It feels like muscle spasms going up and down the spine and moving around the back, I believe this can be caused by internal organ damage... I have an ultrasound coming up, I will let you know the results... but if you too get kidney/lower back pain a day or two after using MXE, post of this thread to let others know + I would discontinue use until you are sure MXE is not involved.
Last edited:
I will say another thing too.. don't forget I was one of the nutters doing spontaneous body movements on MXE... I want these problems to be muscle related rather than organ related, but MXE is still the cause, and this may still be the case, but they are pretty serious spasms and sometimes my guts just feel strange, but as I said, better as time goes on... doesn't hurt much lying down.
amanitadine
Bluelighter
^^^^ I agree with you in that people want methoxetamine to be completely safe, and the truth is we don't know. But we can compare it to substances which are very structurally similar and have a long history of use, and have been studied through and through. Obviously this isn't enough to give us a thorough understanding, but it is a start. The ulcerative cystitis/ketamine connection wasn't even really correlated until 2006/7, and I believe this to be because it seems to effect only some (some have no pains from grams a day for years) and it requires (usually) mammoth doses chronically. Cheap, widespread ketamine is a phenom of the 21st century, and that is why these issues were not widely encountered in the decades of its use earlier.
I am not saying what you are describing is psychosomatic, I hope you understand I've just read several other reports that do sound such. And after the papers on ulcerative cystitis and ketamine were published, reports of bladder and kidney pain went through the roof, even with one time use! The power of suggestion I guess.
What you are describing sounds like something else entirely. It sounds like radiating nerve pain, and the fact that you mention spasms make me think of the incidents of gall bladder spasms resulting from heavy ketamine use. This too is terribly painful, and even less reported and understood than the bladder issues. This I have experienced, and is often the "stomach" pains that heavy ketamine users complain of. Usually localized in the upper left quadrant of the abdomen, but can radiate out along nerve lines, and up and down the spinal column. For me it was remedied by either more ketamine, or stopping ketamine. Win Win? Lose Lose? It was episodic, and felt similarly to gallstone pain, but not quite as centralized. Are you familiar with gall bladder pain?
I agree with you that caution is advised, of course. Listen to your body, it tells you what it needs, and what it doesn't.
Cheers
I am not saying what you are describing is psychosomatic, I hope you understand
I've just read several other reports that do sound such. And after the papers on ulcerative cystitis and ketamine were published, reports of bladder and kidney pain went through the roof, even with one time use! The power of suggestion I guess.What you are describing sounds like something else entirely. It sounds like radiating nerve pain, and the fact that you mention spasms make me think of the incidents of gall bladder spasms resulting from heavy ketamine use. This too is terribly painful, and even less reported and understood than the bladder issues. This I have experienced, and is often the "stomach" pains that heavy ketamine users complain of. Usually localized in the upper left quadrant of the abdomen, but can radiate out along nerve lines, and up and down the spinal column. For me it was remedied by either more ketamine, or stopping ketamine. Win Win? Lose Lose? It was episodic, and felt similarly to gallstone pain, but not quite as centralized. Are you familiar with gall bladder pain?
I agree with you that caution is advised, of course. Listen to your body, it tells you what it needs, and what it doesn't.
Cheers
^^^ psychosomatic responses are so common with drugs, I totally understand, it's like if you use drugs then you get a health problem, it's your most obvious link due to the illicit nature of the thing... but I've got a good scientific mind and I think I've already crossed this line of thinking... I appreciate your views on this, thanks for discussing. Your accounts of gallstone pain resonate much more with me than the bladder cystisis, but I'm unfortunately not familiar with gallstone pain...it's not painful really at all, it's more uncomfortable, it's an odd sensation running around the back and sometimes internally.. often I get odd stitch like feelings in the sides, there have been days where it feels like I can feel my abdomen touching my lungs, freaky but not painful...I have to sit up right to stop it... it's funny what you said about taking more ketamine as a remedy, because MXE's effect on the problem is what brought my attention to it.... there was one time when it seemed like MXE cured the problem, but the next week, it brought it back... I thought that was psychosomatic, haha.... I've got to say again, kratom really helped, it actually surprised me because I assumed kratom may make it worse....
- Status