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The Big & Dandy Methoxetamine(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) Thread

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Out of all the drugs ive tried, and ive tried almost all of em, ketamine was the most addictive.
I have a feeling MXE will be similar for me and many others.

It may be addictive in your mind, but thank God it's not addictive where you need it to function like pain pill addicts need pain pills just to be normal, and if they don't have them they feel like they are crawling out of thier skin. Could you imagine going into work and having ketamine withdraws and needing to IM 100mg of ketamine just to function at your job? Not possible..and never will happen.. I LOVE dissassociates!
 
^^^^ It is quite possible, and not all that unheard of. While it takes some serious, determined effort (;)) to develop a nasty physical addiction to ketamine or PCP or such, it does happen, and it is most unpleasant. I have read bona-fide reports of people needing upwards of 7 grams a day of ketamine to function. Strange but true.......There have been a lot of people on this site over the years who have battled terrible addictions to ketamine, both mental and physical.

And while the nature of the physical dependence isn't as straightforward and cut and dry as opioids, it is real, and addicts in withdrawal are show alot of the same symptoms as opioid withdrawal: tremors, goose bumps, horrible stomach problems, anxiety and malaise, etc etc. And has been stated, the mental addiction to disassociatives is the worst out of any drug I've been addicted to.....even blows the pleasure circuit rewiring of intravenous cocaine outta the water! It was not unheard of to storm into a veterinary clinic into the middle of the night in search of some ketamine..yikes.

For me, methoxetamine is a lot less hedonistic and compulsive than ketamine or PCP or such. In fact, I have yet to redose once after a session....whereas with K and friends I used to do it until it was gone. Guaranteed. It has been a few years since my epic bouts with arylcyclohexylamines, maybe I've grown a bit, but it seems more to me to be the nature of the substance. At least personally. I'm sure some will find it the bees knees and go nuts over it.....luckily it will be somewhat of cost-prohibitive venture. But some have spoken of an anti-addictive nature with MXE, and while I don't know it I would go that far, I would say for me it is self limiting, and the rewards it provides (especially in relation to self awareness, spiritual growth, and examining my addictive natures, the paths I have taken, mistakes and regrets, and interpersonal relationships....MXE really shines here for me! Beauty!) still outweigh the potential negatives by a long shot. Caution is advised, granted, but I hope it shines in others as it has in myself.

Have fun, be safe<3
 
(I've not been keeping up with this thread, but since I've posted the following review onto my trip report i figure its probably ok to post it here too)


Since that first report a few weeks back I've done a fair few experiments with this chemical.

As an old-skool ket-head, I've come to realise how very different this drug is. It's certainly its own thing and should be treated as independently as any other dissociative, irrespective of molecular similarities or marketing strategies.

Aside from the aforementioned opioid effects, there's what I can only really describe as a kind of headrush type effect at higher doses, comparable in some ways to higher dose DXM or Nitrous, yet still kinda different. In comparison to K, sensory distortions seem to be less pronounced but still significant, motor functions and instinctual actions seem to be far more impaired. With K I find I have a sort of autopilot that I can generally trust to function pretty much normally and even perform various mildly complicated tasks, this autopilot is not so good on this stuff, couple of times I've been unable to even make a roll-up at the peak of MXE effects.

By far and away, in my opinion though the greatest difference here is the mania-effect (due to higher levels of DRI antagonism I believe, correct me if I'm wrong). This mania seems to have a really significant, somewhat OCD-like effect which, in the wrong person or the wrong environment, may well prove frightening. For many, like myself, this mania can be quite exciting but may seem odd or irrational to onlookers.

The Mrs has decided quite definitively that she doesn't like this drug and has no wish to ever take it again, she can be a touch on the OCD side herself at the best of times and this mania really doesn't play well with her. Personally I find that provided you have something to focus the mania on then its fine (me and a friend spent well over an hour looking at photos of caves online in a bid to find the perfect party venue). Again, what works for me doesn't necessarily work for everyone.

As far as dosage is concerned, for someone like myself with a fair old K tolerance, 50-100mg lines seems to be a good bet, with a dosage of 200-250mg total in one session as a limit.

I've actually found that infrequent smaller lines (less than 50mg per hour) can be quite pleasant as a little background thing, mild dissociation but with little to no visual/sensory distortion, allowing me to surf the web, watch telly and generally do anything I would normally do (with the obvious exceptions)

I haven't properly mixed this with mephedrone (Mortal Kombat-style) as I get a feeling this one could be quite dangerous, however I have sniffed this coming down from mephedrone and I can confirm that even tiny little bumps of this can be just as effective at combating drone-fiending as regular K.

I've also mixed this with K, I had some not-too-strong stuff that I decided to spice up with a little of this the other night and it sent me right off on one, simultaneously highly enjoyable and disturbingly wrong, definitely stronger than this on its own, but more like this than K. One to be careful with and, I would suggest, one for the more experienced ket-head.

As it stands myself, I feel like I have explored this one pretty thoroughly now, for all its nice quirks and shines, it just doesn't hold a candle to proper K. There is nowhere near as much depth to be found in here as can be found in a good K-hole, and once that initial novelty wears off this one seems very much like a one-trick-pony when compared to its adaptable, enlightening and multi-talented cousin. I can't really see me doing a great deal more of this, maybe the odd line now and then but that's about it.
 
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I doubt methoxetamine is anti-addictive, but I think it gives a very satisfying high. Hardly any drugs are satisfying. The drugs that feel like orgasms leave you craving for more (Like MDMA, and I'd imagine strong opiates). The drugs that feel like stimulants leave you chasing the high because you 'aren't quite there yet'.

Methoxetamine doesn't make me react like this at all though. I love it to pieces, I've nearly gotten through 2 grams since it launched, but if it had any sort of compulsive edge to it, trust me those 2 grams would have disappeared within 48 hours. MXE just leaves me satisfied...like a sunday roast.....Enough is as good as a feast.
 
well, I kinda stayed away from RCs after mephedrone got banned cause I had tried 2 of the *replacements* with quite horrible outcomes.
but I need to try this, this one sounds almost too good. so many happy people ;) i just hope the bit i ordered will be decent quality (well..what means decent actually). I just hope its not crap. I havnt been reading all the 54 pages of this thread but in what I read I dont seem to recall people telling they got crap... will keep my fingers crossed!
 
Did you find any decent caves? Are you able to post some links?


(I've not been keeping up with this thread, but since I've posted the following review onto my trip report i figure its probably ok to post it here too)


Since that first report a few weeks back I've done a fair few experiments with this chemical.

As an old-skool ket-head, I've come to realise how very different this drug is. It's certainly its own thing and should be treated as independently as any other dissociative, irrespective of molecular similarities or marketing strategies.

Aside from the aforementioned opioid effects, there's what I can only really describe as a kind of headrush type effect at higher doses, comparable in some ways to higher dose DXM or Nitrous, yet still kinda different. In comparison to K, sensory distortions seem to be less pronounced but still significant, motor functions and instinctual actions seem to be far more impaired. With K I find I have a sort of autopilot that I can generally trust to function pretty much normally and even perform various mildly complicated tasks, this autopilot is not so good on this stuff, couple of times I've been unable to even make a roll-up at the peak of MXE effects.

By far and away, in my opinion though the greatest difference here is the mania-effect (due to higher levels of DRI antagonism I believe, correct me if I'm wrong). This mania seems to have a really significant, somewhat OCD-like effect which, in the wrong person or the wrong environment, may well prove frightening. For many, like myself, this mania can be quite exciting but may seem odd or irrational to onlookers.

The Mrs has decided quite definitively that she doesn't like this drug and has no wish to ever take it again, she can be a touch on the OCD side herself at the best of times and this mania really doesn't play well with her. Personally I find that provided you have something to focus the mania on then its fine (me and a friend spent well over an hour looking at photos of caves online in a bid to find the perfect party venue). Again, what works for me doesn't necessarily work for everyone.

As far as dosage is concerned, for someone like myself with a fair old K tolerance, 50-100mg lines seems to be a good bet, with a dosage of 200-250mg total in one session as a limit.

I've actually found that infrequent smaller lines (less than 50mg per hour) can be quite pleasant as a little background thing, mild dissociation but with little to no visual/sensory distortion, allowing me to surf the web, watch telly and generally do anything I would normally do (with the obvious exceptions)

I haven't properly mixed this with mephedrone (Mortal Kombat-style) as I get a feeling this one could be quite dangerous, however I have sniffed this coming down from mephedrone and I can confirm that even tiny little bumps of this can be just as effective at combating drone-fiending as regular K.

I've also mixed this with K, I had some not-too-strong stuff that I decided to spice up with a little of this the other night and it sent me right off on one, simultaneously highly enjoyable and disturbingly wrong, definitely stronger than this on its own, but more like this than K. One to be careful with and, I would suggest, one for the more experienced ket-head.

As it stands myself, I feel like I have explored this one pretty thoroughly now, for all its nice quirks and shines, it just doesn't hold a candle to proper K. There is nowhere near as much depth to be found in here as can be found in a good K-hole, and once that initial novelty wears off this one seems very much like a one-trick-pony when compared to its adaptable, enlightening and multi-talented cousin. I can't really see me doing a great deal more of this, maybe the odd line now and then but that's about it.
 
Just a quick note, there is much discussion about how the 3-methoxylated arylcyclohexlamines produce opioid effects, but there is little scientific evidence to support this. A friend recently had 3-MeO-PCP screened at the µ-opioid receptor and found its affinity to be totally insignificant. This is not to say that MXE is not euphoric or habituating, but that it's probably producing said effects through NMDA-antagonism.

Well, I'm far from an expert but levomethorphan a structurally similar compound has very minimal MOR activity also, but its metabolite levorphanol is a fairly potent opioid. In the case of methoxetamine or the methoxylated phencyclidine analogs, an O-desmethyl metabolite may explain some of the opioid activity although no opioid agonism would surprise. One possible way to gauge this would be to see if there's an increase in the number of people who report opioid effects, or increase in opioid tolerance after oral or intrarectal use when compared to parenteral use. It would also be interesting to see the 2-ethylamino group replaced with a dimethylaminoethyl group.
 
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This and 6-APB, good idea or bad idea? Just had 50mg of MXE and have some Benzo Fury left over.
 
In the case of methoxetamine or the methoxylated phencyclidine analogs, an O-desmethyl metabolite may explain some of the opioid activity

Possible, though it is equally likely that the 3-hydroxylated metabolite (if it is indeed produced) would behave as an antagonist at the MOR:

On the opioid nature of phencyclidine and its 3-hydroxy derivative

Phencyclidine (PCP) and its 3-hydroxy derivative (PCP-3-OH) caused a dose-dependent, naloxone reversible inhibition of the response of the guinea pig ileum to electrical stimulation. Unlike PCP, PCP-3-OH exerted an opioid antagonistic effect in the mouse vas deferens bioassay. Whereas both compounds displayed a high affinity in displacing [3H]SKF-10047 binding to rat brain membranes, PCP-3-OH displayed a high affinity to [3H]morphine receptors also. The mediation of σ- and μ-receptors in the opioid effects of these drugs is discussed.
 
^^^^ Well this is interesting. Several of the old classic refs on phencyclidine make mention that an added 3-HO group increases the affinity for the MOR by 4-500x. But I have never seen actual ki values and more importantly never any IC50 data. I suppose high affinity no efficacy makes sense as well with what I've seen. There is a lot of conflicting data on the opioid effects of phencyclidine and its analogs! There aint much to go on with what you listed above, not clear exactly with the scant info. What's the source, I'm curious?
 
Err, the source is "On the opioid nature of phencyclidine and its 3-hydroxy derivative"

I will have the opportunity to chemically analyze and taste a bit of the official MXE batch within the next two weeks, will keep everyone posted.
 
If it is an antagonist it is probably an unusually weak one. I've seen a few reports of opiate addicts taking this compound with no report of precipitated withdrawal. Aside from that paper, does anything else make you think it is just as likely to be an MOR antagonist? I don't know of any N-ethylated MOR antagonists personally. What are your thoughts of sigma receptors producing the effects ascribed to MOR agonism? A lot of what I'm seeing in the reports for this one seem to point in that direction to me.
 
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There are also drugs that bind at a given receptor as a silent antagonist. Whatever the case may be with MXE, I think MOR affinity does not play a significant role, though I could be totally wrong. Also, thought it was once classified as such - the sigma receptor is not an opioid receptor - I have no idea how it contributes to the experience because I have never tried a selective sigma agonist.
 
ham, I'm having a hard time understanding what makes a silent antagonist special. I understand that it doesn't have any intrinsic activity at the receptor it binds to, just like any other antagonist. I also grasp the concepts of the various types of antagonists (competitive, non-competitive, etc.), so is it plainly that the silent antagonist binds to the same binding site at the receptors that agonist ligands bind to, but doesn't prevent the binding action of the said agonist ligand? So under conditions that no agonist ligands are in the synaptic cleft, or there aren't enough ligands to bind to all the of the available receptors, the silent antagonist remains blockading some or all of the receptor sites, but not causing any changes in activity of a neuron (not preventing an action potential from taking place as no agonist is trying to induce a response). However, when the agonist ligands flood the synaptic cleft the silent antagonists make way with out preventing the agonist from initiating their biological response, as well as not change the conformation of the receptor, and doesn't alter the response of an neuron from the agonists binding in any way. So in a sense they don't do anything? If I am correct, I'm assuming there is no value in investigated silent antagonists/their activity as a silent antagonist at receptor, as there should be none.
 
Err, the source is "On the opioid nature of phencyclidine and its 3-hydroxy derivative"
.

Err, I did gather that much, was more looking for an author. Couldn't find it by title alone, and it is hard to make much sense out of context and details. ;)

Thanks!

*edit* Err...Derrr....Funny how specialized journal ref search engines can bring up nothing and then overlooked google brings it up on the first hit...

Without paying for the full article I still don't know what to conclude. The synopsis confuses me, and seems to highlight more the differences depending on the substrate used for the assay. The author has done some more work that seems to only blur the line between whether it is an agonist or an antagonist more. (at least for me...but I'm a bit out of my realm here ;)) I could conclude either?

Interaction of two phencyclidine opiate-like derivatives with 3H-opioid binding sites
Nicole Johnson, Yossef Itzhak, and Gavril W. Pasternak

Small modifications of the basic structure of phencyclidine have produced compounds with potent opioid analgesic actions. Detailed competition studies show that two of these phencyclidine derivatives, the 3′-hydroxy and the 4-phenyl-4-hydroxy analogs, displace 3H-opioid binding in a multiphasic manner. Approximately 25% of the total specific binding of all the radiolabeled opioids is displaced by low concentrations of the derivatives while the remainder of the binding is far less sensitive. The inclusion of these derivatives in saturation studies with [3H]dihydromorphine indicate that both compounds interact with highest affinity with μ1 sites. Furthermore, the prior in vivo administration of naloxonazine 24 h earlier reduces the analgesic potency of the 4-phenyl-4-hydroxy compound by 63% supporting a μ1 mechanism of action.

So who knows what this means for methoxetamine. We don't know if it is o-demethylated, or how it is metabolized (save for the speculated N-dealkylation). I know PCP is hydroxylated at the 4-position (cyclo ring..well, pip ring too but not relevant here..) during its metabolism (as is ketamine) and then conjugated with gluconorate and such. I believe ketamine has been shown to undergo slightly differing metabolic rates and processes for each stereoisomer as well, so we could assume methoxetamine might behave similarly....

Subjectively, I feel no MOR action....and after as many years as I spent addicted to opioids, my system is pretty gosh darned sensitive. Emphasis on subjectively...;)

Interesting. Let us know what yr analysis of the "official" methoxetamine turns out. I got a single spot on TLC but that is about where my technology ends. What method did your friend use to screen 3-MeO PCP for MOR activity? Will you repeat this with methoxetamine?

Cheers
 
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This and 6-APB, good idea or bad idea? Just had 50mg of MXE and have some Benzo Fury left over.

Under any circumstances, do. Not. Do. This.

I did 60mg of MXE (with a bit of a tolerance, did it the day earlier as well) when I was just coming down off of a moderate dose of 6-APB. I felt like I was doing permanent damage to myself. I could feel my brain degrading, I thought I'd be mentally impaired for the rest of my life. I've no idea what it was but I just knew something was very wrong with me. I was fine after a night's sleep but this was the first time I thought I was being fatally idiotic with drugs.
 
I didn't take any 6-APB eventually, thank god.

I have been suffering from a dull aching in my stomach for the past few days though.

Anybody else had any possible side effects from MXE use?
 
Woo, its been big and dandied!. Sacho some people have noticed aching stomach and kidneys when using mxe/ketamine etc, i for one don't know why but i think it might just be part and parcel. Were you taking mxe orally or intranasally?
 
Woo, its been big and dandied!. Sacho some people have noticed aching stomach and kidneys when using mxe/ketamine etc, i for one don't know why but i think it might just be part and parcel. Were you taking mxe orally or intranasally?

Intranasally. I thought that was just with long-term users. Never touched either before. Does the pain diminish and go eventually?
 
new user here ;)
i´ve just ordered myself 2g of this stuff, does anyone have thoughts on combining this with venlafaxine?
according to the antidepressant+drugs faq combining an srni with k issnt any problem, but does this also apply to methoxetamine?
 
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