(I've not been keeping up with this thread, but since I've posted the following review onto my
trip report i figure its probably ok to post it here too)
Since that first report a few weeks back I've done a fair few experiments with this chemical.
As an old-skool ket-head, I've come to realise how very different this drug is. It's certainly its own thing and should be treated as independently as any other dissociative, irrespective of molecular similarities or marketing strategies.
Aside from the aforementioned opioid effects, there's what I can only really describe as a kind of headrush type effect at higher doses, comparable in some ways to higher dose DXM or Nitrous, yet still kinda different. In comparison to K, sensory distortions seem to be less pronounced but still significant, motor functions and instinctual actions seem to be far more impaired. With K I find I have a sort of autopilot that I can generally trust to function pretty much normally and even perform various mildly complicated tasks, this autopilot is not so good on this stuff, couple of times I've been unable to even make a roll-up at the peak of MXE effects.
By far and away, in my opinion though the greatest difference here is the mania-effect (due to higher levels of DRI antagonism I believe, correct me if I'm wrong). This mania seems to have a really significant, somewhat OCD-like effect which, in the wrong person or the wrong environment, may well prove frightening. For many, like myself, this mania can be quite exciting but may seem odd or irrational to onlookers.
The Mrs has decided quite definitively that she doesn't like this drug and has no wish to ever take it again, she can be a touch on the OCD side herself at the best of times and this mania really doesn't play well with her. Personally I find that provided you have something to focus the mania on then its fine (me and a friend spent well over an hour looking at photos of caves online in a bid to find the perfect party venue). Again, what works for me doesn't necessarily work for everyone.
As far as dosage is concerned, for someone like myself with a fair old K tolerance, 50-100mg lines seems to be a good bet, with a dosage of 200-250mg total in one session as a limit.
I've actually found that infrequent smaller lines (less than 50mg per hour) can be quite pleasant as a little background thing, mild dissociation but with little to no visual/sensory distortion, allowing me to surf the web, watch telly and generally do anything I would normally do (with the obvious exceptions)
I haven't properly mixed this with mephedrone (Mortal Kombat-style) as I get a feeling this one could be quite dangerous, however I have sniffed this coming down from mephedrone and I can confirm that even tiny little bumps of this can be just as effective at combating drone-fiending as regular K.
I've also mixed this with K, I had some not-too-strong stuff that I decided to spice up with a little of this the other night and it sent me right off on one, simultaneously highly enjoyable and disturbingly wrong, definitely stronger than this on its own, but more like this than K. One to be careful with and, I would suggest, one for the more experienced ket-head.
As it stands myself, I feel like I have explored this one pretty thoroughly now, for all its nice quirks and shines, it just doesn't hold a candle to proper K. There is nowhere near as much depth to be found in here as can be found in a good K-hole, and once that initial novelty wears off this one seems very much like a one-trick-pony when compared to its adaptable, enlightening and multi-talented cousin. I can't really see me doing a great deal more of this, maybe the odd line now and then but that's about it.