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The Big & Dandy Methoxetamine(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) Thread

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newworldorder said:
does anyone have any experiences of increased heart rate?.
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I've had this happen a few times, one time was mixed with a stimulant. I tried not to worry about it and I forgot about it pretty fast. The other times I simply took either asprin or paracetamol
 
This concept is supported by recent reports, which reveals that the i.v. anaesthetic, ketamine, inhibits nicotinic cholinergic excitation in cardiac preganglionic parasympathetic neurons of the nucleus ambiguus of the brainstem 8 . It has also been indicated that heart rate is modulated by the parasympathetic nervous system in a nicotinic cholinergic-dependent manner, suggesting an involvement of nicotinic acetylcholine receptor (nAChR) channels
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http://www.ispub.com/journal/the_in...ed_atrial_preparation_taken_from_the_rat.html




mr.mackey said:
I'm guessing this girl's heart concerns were primarily psychological rather than physiological. However that does not mean that caution should be thrown to the wind so to speak.

I'm guessing the stimulant properties have more to do with any dopamine reuptake inhibiting properties, because as far as I know, ACh (acetylcholine) doesn't have much to do with the stimulating properties of any drugs. I'd say thats usually attributed to norepinephrine and dopamine, and I as far as I have heard, methoxetamine is more likely to be a dopamine reuptake inhibitor than a norepinephrine reuptake inhibitor.

perhaps someone from ADD or more knowledge will correct me if Im wrong
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abore said:
I'm curious if anyone has any experience mixing this with nitrous?
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Yep, I recently bought 100 nitrous cannisters (obviously already have a charger and balloons). Then I recently bought some MXE, so have been taking nitrous pretty much every time I've taken MXE.

It was fun. Not mind-blowing, but it definitely added an interesting perspective to things. It's worth bearing in mind that MXE, for whatever reason, doesn't get me spangled beyond belief - I am incapable of space travel on this drug. Sometimes I get the opiate/sedated effects (mildly, though), my head usually gets fuggy and "outside of myself", and I slip wonderfully into confusion whilst being happy about the fact - but no space travel, not even after insufflating 90mg.

Anyway, back to my point :)

I found nitrous on MXE to be fun. I did a double-balloon once and proclaimed to my girlfriend (when returning to reality) that I felt as if I was trapped inside a glass chopping board.

I also found it kind of fiendish. When I took a lot of 2C-E and MXE I must have got through 5-10 cannisters, I lost count though (some were doublers).

In conclusion... yeah, it's fun. Not mind-expanding and nothing to write home about (not that I would write to my parents about my drug experiences) but it's worth doing. It's a giggle.

Then again, nitrous is fun on drugs in general, isn't it? :)
 
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newworldorder said:
does anyone have any experiences of increased heart rate?.
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The first few times on MXE I checked my pulse repeatedly. Not in a kill-joy "oh my God I need to check my heart-rate or I'm going to die" kind of way, just in a curiousity/safety-first kind of way. It was completely stable.

So, no. Sorry that I can't be of help. Just pointing out that my heart-rate was unchanged :)

JSPete said:
Was it your girlfriend's first time on MXE? The fear of the unknown, especially when the unknown feels confusing and overwhelming, is good reason for you to panic and thus have increased heart rate.
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This makes a lot of sense. Perhaps it was this?


incognition said:
One dead from heart attack after combining with MDAI, 2 guys snorting 400 mg to the hospital where one of them "almost had an heart attack". And now this girl.

I think it's a "good idea" to not combine this drug with stimulants.
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The MXE+MDAI guy did like 400mg MDAI (that's a lot) and IVed close to 100mg MXE. He was a fool. It's a damn shame and I feel sorry for the guy, but seriously, that was never going to be a safe thing to do.

Snorting 400mg of a New Thing? Come on. They're very lucky that they only "almost" had a heart attack.

Anyway, rant over. Question time regarding MXE+stimulants: how about sniffing a little bit of this whilst on MDMA? Sniffing ketamine and MDMA is a favourite pastime of mine, it adds a spangly tinge to the proceeding and softens the comedown. If I had no K but had MXE (I definitely have MXE by the way:) would this be a Very Foolish Thing? Or might it be okay? Pure speculation welcome.
 
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If yatzi isn't a troll that have something against "the original vendor", it's kind of worrying that he said they got dilated pupils. Could this drug have a strong anticholinergic action in high doses? Like tropanes - Atropine etc. Used medically to increase heart rate. They give dilated pupils. And a good dose of insanity..

Prolly just my imagination.. but where are the experts?
 
newworldorder said:
i should add that she did not have the beating heart till we tried to go to bed at about 9am
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I find this compound to be quite stimulating, moreso than ketamine. So much so that I would be concerned about combining with stimulants, especially in light of the reported death.
 
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just to be clear about my gf's heart prob ... we had been playing poker and having a few lines of cocaine and drinking... (cred out the window) then had the MXE which was an afterthought and admittedly a bit recklass. Anyway after the first very small line we werer noticeably excited and mildly stimulated and tried another then one more maybe 30 mins later... after that we went into timewarp and next thing we knew it was 7 am and we were all pretty shocked but all agreed we had had a good time. we went to bed had sex then afterwards her heart was beating really fast ( i would like to claim responsability for her raised heart rate but that doesn't ever happen even if we had had a heavy coke session which we had not)

Anyway maybe it was psychological or cocaine or sex related but that would not be normal, the only difference that night was the MXE which we/she really enjoyed but I think if this drug is going to be used by polydrug users these things should be explored and therefore users can know what to expect.

ALSO......

I gave a 0.5 gram to a friend and asked him to check it out and 'be careful'. Anyway he looked at the internet reports etc and then decided he would 'do the whole lot' in two lines....! This guy has a huge appetite for K.

I got a call at 12pm from my other friend saying what he had done and that other friend was on the floor... where he remained for the next 90 mins.. anyway i spoke to him briefly after that whereupon he sounded fine and mumbled something about him being a psychonaut. I asked him what he thought and whether he liked the experience where he said definately yes.. after that my other friend said he tried to go home... then returned as he couldn't find his way !
 
I gave a 0.5 gram to a friend and asked him to check it out and 'be careful'. Anyway he looked at the internet reports etc and then decided he would 'do the whole lot' in two lines....! This guy has a huge appetite for K.

I got a call at 12pm from my other friend saying what he had done and that other friend was on the floor... where he remained for the next 90 mins.. anyway i spoke to him briefly after that whereupon he sounded fine and mumbled something about him being a psychonaut. I asked him what he thought and whether he liked the experience where he said definately yes.. after that my other friend said he tried to go home... then returned as he couldn't find his way !
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Please either ask your friend to be more responsible or keep him the fuck away from this stuff until we know more about it's safety.
As has been said (repeatedly!), this is not ketamine!
 
I'm seeing a definite correlation between combining MXE with stimulants and dangerously high heart rates. Ewww.
 
I certainly agree his actions were reckless and people should NOT take that as MXE is safe to take large dosages. I merely relay this story as an accidental /reckless experiment which ,thankfully, had a happy outcome.
 
Might be worth noting that I also noticed a pronounced heartbeat on going to sleep a couple of nights ago. Had probably dosed 50mg in the night.

Symptoms/signs correlate with a slightly elevated systolic BP, which I also get when I have been drinking (sensible amounts of) alcohol.

Didn't take BP but HR was only very slightly above normal (65bpm at rest vs 55-60 normal).

Seems like a minor consequence at a recreational dose (I've found that 50mg is easily twice as much as the "sweet spot" dose; 25mg puts me in a beautifully relaxed state with no mania or panic response thankfully :) ).

I would be very interested to hear the thoughts from those with chemistry knowledge as to whether they think this substance is behaving in-line with their earlier predictions, or are we seeing something unexpected coming out here?
 
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I just recieved my 500 mg of MXE today, 19.25 i did a small 5mg line to check for any bad reactions, felt nothing at all so i took 15 mg at 20.10. My head is now (20.55) feeling very thick and heavy if that makes sense and sort of achy, ive also drank four cans of beer so far and alcohol is a daily habbit of mine and i know its not just the beer making me feel like this, it is not very pleasant. Has anyone else had any feelings like this ? Also to note i had very little alcohol intake last night and didnt get a good night sleep due to that and was sweating all night but feeling very cold.
 
Dosages for rectal use should be approximately the same as those for IM use. My usual ROA is IM and I use dosages of 10-100mg. 100mg being the absolute max I would use.
 
i feel very good now , iv had a few more lines unweighed , and i can say it is almost like ketamine except i feel nice n like in cotton wool now lol, but im hearing a constant noise which i cant explain
 
deckmunki said:
I would be very interested to hear the thoughts from those with chemistry knowledge as to whether they think this substance is behaving in-line with their earlier predictions, or are we seeing something unexpected coming out here?
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I haven't personally noticed anything alarming with myself nor anything defying SAR expectations whatsoever. As has been stated, even ketamine ( viewed as one of the most sedating members of this class) can elevate the heart rate a bit. And even so, the ketamine comparison is a bit of a stretch, as it is arguable that this substance is "closer" in structure to PCE (methoxetamine being the 3-Meo 2-Ketone analog of PCE) which is famed for causing even more mania than PCP. In theory the oxygen (the 2-ketone) gives the body point to latch onto and begin metabolizing, thus shortening the duration, etc. I've had pronounced mania and stimulation from 3-Meo PCE as is, but agreedly methoxetamine feels much more benign, as it "should". With semi-reasonable dosing (not taking 400 mg your first time, etc 8)) I don't think this should present an issue with most people. But then again, who the fuck am I, people are anything but reasonable, and this is still a relatively new substance.

Cheers, Be safe<3

edit - Not to be a killjoy, but I also think the "methoxetamine not being subject to the USA's analog act because Ketamine is schedule III"I stance is funny because PCE is schedule I. I don''t think it will be too much of an issue though...I'm sure it will get banned in the UK shortly if people carry on foolishly..:|
 
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