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mephedrone long term negative effects progress reports

I've only started taking meph this year, but I've got myself quite into it. Got to the point where I was spending three days awake on it once a week for several weeks, but I've stopped doing more than a one-nighter since a 4-day session broke me more than anything else ever.

I've not had many of the side-effects noted above, when I'm on it I feel completely fine physically and mentally. However, if I go more than 24hrs without it, I get anxious, very emotionally sensitive (feeling like crying if I read sad news, or even something hopeful), and also palpitations. These are best described as feeling my heart beat in hands, legs, neck and occasionally elsewhere, usually also felt in my head and causing temporary (for the duration of the throbbing) fatigue feelings. These feelings all go if I have a small dose (for me about 80mg).

I'm taking up to a gram a day, and feel a lot of need to do it at work (I work in a call centre, so the ability to talk freely and good-naturedly is far preferable to anxiety and self-consciousness), usually 250-400mg over an 8-hour workday.

I should point out that I don't get gurning, eye twitching or any other physically obvious reactions except increased sweating, and the need to hold little bits of tissue under my nose if I can't be bothered to bomb it :-).

Of the three main withdrawal symptoms I get, the first two seem explainable by psychological factors/serotonin levels, but the palpitations make me worry that the addiction may also be physical. I'm not aware of any physically addictive uppers though, so is this more likely a vasoconstriction side-effect, and if so why does redosing make it go away?

I'm aware that I really do need to stop taking this stuff with any sort of regularity, but I feel I'd need at least two days off it (and maybe quite a few benzos) to break the symptoms well enough to ride it out, but work being as it is, getting this time off to coincide with when there's no parties I want to go to is proving problematic.

Mind you, it's now become almost impossible to get hold of so probably I'll soon have to have an enforced withdrawal. I'm not looking forward to that (and the anxiety I feel when my supply's almost gone) makes me think it'll be best in the long run.

In reply to the posters who've mentioned sore throats, this is clearly caused by the caustic nature of the drug, so it's best to only snort it occasionally. Gel caps or Rizla bombs are both perfect for eating purposes, but this can just defer the problem elsewhere. I have quite a sensitive stomach (due to having a bit of a tantrum and taking 30 aspirin tablets a decade or so back), and I get nasty acid stomach after 3 pints of cider/more than 12 hours drinking anything alcoholic, having an empty stomach for too long and also from bombing meph.

Of course, if I've been bombing meph for a while it's pretty likely my stomach's fairly empty and there's been sustained drinking, so I whether this stomach burn is a universal thing is not known.

Of course, if you want to go as long as possible on it without getting chemical burns anywhere, you could always go for #1 up the nose, #2 down the throat and #3 up the Gary (definitely use a gel cap here). Repeat until you're a screaming mass of whole-body burns. Ladies can get 33% more fun by using their jacky danny for #4.
 
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I thought that 4-fluoro-ephedrine was also confirmed highly toxic (that is, with a therapeutic index worse than ephedrine's), but we haven't seen any nightmares with it due to people taking on more conservative dosing regimens with flephedrone in comparison to mephedrone.

ebola
 
im having so many bizarre side effects (perhaps the most severe of which is hypochondria) but the roof of my mouth is covered in agonizing cuts which will not heal, i have horrible throbbing sensations in my legs and feel generally shitty. i have also been not sleeping (not this was after only one dose of 100mg)

Sorry mate, but I'd say that with a 100mg dose causing those kind of effects - you've got some other issues going on....the stuff only really begins to be active at that amount.

Having said that, I'm glad the 'era' is over as it certainly is very psychologically addictive (never really felt it physically, as after 24 hours awake I'm just over it tbh and stop). It was fun whilst it lasted and I'm forced to stop now which I'm quite happy about!
 
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I'd tend to be wary with ever beta-ketone as they all seems to be not very favorable in the costs/benefits ratio compared to their amphetamine analogues. This can perfectly be BS, it's just a gut feeling.
 
Sorry mate, but I'd say that with a 100mg dose causing those kind of effects - you've got some other issues going on....the stuff only really begins to be active at that amount.

I don't agree. Psychostimulant sensitivity has a quite wide range of variation, and a dose of e.g. amphetamine that is mild for some can produce toxic effects in a few others. I don't think he's a wild outlier either.
 
Another bad experience with mephedrone here from me. Total usage 2.25g I reckon over 5-6 or 7 sessions, sometimes weeks apart.

Last time I tried it I insuffated about 50-100mg roughly (3 months ago roughly) before I noticed I had slightly blue fingers and feet and slightly itchy skin, also redder skin overall. The next day the blueness was gone bur I had a quite noticable tanning / skin darkening effect.

Since then I have been getting red/blushing skin on my hands, forearms, feet and lower legs. I have always been slightly blushy and had reddish palms, it definitely seems more pronounced now though and this has me fairly worried. No heart palpitations or any other symptoms apart from redness really. Still looking quite tanned, although I have dark hair and tan easily.

As for more background info I seem to have somrt sort of inflammatory problem in my back that flares up occasionally, (possibly have Anklyosing Spondylitis although docs are leaning away from that now) and get regular acid reflux / heartburn. I lift weights at the gym 3 times a week (no steroids) and have just started running, overall slim/athletic, fit and healthy (good diet, multivitamin).

I took some suppliments that are supposed to help cirulation but it didn't seem to help, these were: Ginko bilboa (dry pill form) L-arginine, a vitamin B complex and magnesium.

Any help or advice would be appreciated, or this info could just be useful info to someone else perhaps.

I thought the effects were going away but it stills seems noticable occasionally. The problem is I never paid much attention to it before and I may have been like this often before trying meph, only now I am concious of it and notice it more. I am almost certain i'm redder overall and blood returns to pressed skin slightly slower than before however.

Has anyone who has had the blushing/vasoconstrictive reaction actually had it go away at all? Thanks
 
Another bad experience with mephedrone here from me. Total usage 2.25g I reckon over 5-6 or 7 sessions, sometimes weeks apart.

Last time I tried it I insuffated about 50-100mg roughly (3 months ago roughly) before I noticed I had slightly blue fingers and feet and slightly itchy skin, also redder skin overall. The next day the blueness was gone bur I had a quite noticable tanning / skin darkening effect.

Since then I have been getting red/blushing skin on my hands, forearms, feet and lower legs. I have always been slightly blushy and had reddish palms, it definitely seems more pronounced now though and this has me fairly worried. No heart palpitations or any other symptoms apart from redness really. Still looking quite tanned, although I have dark hair and tan easily.

As for more background info I seem to have somrt sort of inflammatory problem in my back that flares up occasionally, (possibly have Anklyosing Spondylitis although docs are leaning away from that now) and get regular acid reflux / heartburn. I lift weights at the gym 3 times a week (no steroids) and have just started running, overall slim/athletic, fit and healthy (good diet, multivitamin).

I took some suppliments that are supposed to help cirulation but it didn't seem to help, these were: Ginko bilboa (dry pill form) L-arginine, a vitamin B complex and magnesium.

Any help or advice would be appreciated, or this info could just be useful info to someone else perhaps.

I thought the effects were going away but it stills seems noticable occasionally. The problem is I never paid much attention to it before and I may have been like this often before trying meph, only now I am concious of it and notice it more. I am almost certain i'm redder overall and blood returns to pressed skin slightly slower than before however.

Has anyone who has had the blushing/vasoconstrictive reaction actually had it go away at all? Thanks
Hey there, this sounds similar to my experiences of long-term negative effects of using mephedrone and methylone. After a few months of intermittent and sometimes more chronic and excessive use, even a tiny amount of either (say around 15 mg) set off this reaction, with apparent vasoconstriction (which I've never really had otherwise before, except around the time before I gave up cannabinoids - temporarily - and nicotine - permanently) in the form of pain and cold in the extremeties, very dry skin and bluing and vascular weirdness.

Yes it did go away mostly after a period of time (of non-use of the relevant substances) similar to the period responsible for it (i.e. a matter of weeks to months to return to baseline sensitivity).

I'd be curious to know what explanations there are for enhanced sensitivity to a stimulant. Are there cardiovascular functions that should counter the stress of stimulants but which are semi-permanently damaged or down-regulated by the use of these drugs?

ETA: @fuckmcat You say you still get these symptoms sometimes. Is there any chance this is related to the use of other stimulants (e.g. caffeine, nicotine)? Personally, I find that a sufficient dose of coffee can be sufficient to produce similar (if usually milder) symptoms.
 
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I think that mephedrone somehow upregulates the alpha 2 andronergic receptors leaving you permanently alot more sensitive to the vasoconstriction by other stims.
 
@invert

I actually am getting bad acid reflux (unrelated to drugs or anything else) right now so am not consuming caffiene at all or any other stimulants I can think of. Part of me thinks I had the same redness before but never took any notice, another part does feel that it is deffinitely more noticable and has lingered since taking mephedrone. I am still more tanned than I would expect considering i've not been in the sun for months and months. I have taken no other drugs since (and won't either) and have been very clean / healthy.
 
My experience

Hi guys,

Just wanted to do a quick post on mephedrone use as I wanted to warn people about the effects its had on me.

I have used it for about a year, about 12 times in total and I have some very alarming symptons associated with its use. After the second to last time I used it I found that I had problems with speech, and couldn’t remember words correctly. Following on from that, I tried it once more, and now have ‘tremors’ associated with the early onset of Parkinsons. These occurred right after the last time I took it (the next morning), and get better or worse, so sometimes I won’t have any, and sometime’s they’ll be all the time. I also feel like my cognitive functioning has been impaired and I make mistakes that I would never previously have made.

This statement

“There may be a large number of people out there with half the nerve cells they're supposed to have." In ten or 15 years, he predicts, as these addicts continue to lose substantia nigra cells as part of the normal aging process, California may become the scene of a Parkinson's epidemic.”
From this website :

http://www.time.com/time/magazine/article/0,9171,1101850408-141542,00.html#ixzz0qT4p5cOb

…Really scares the shit out of me. I feel like I’ve ruined my whole life. It was my fault, I know, I am responsible for what I put in my body, and I’d just feel like I should do my bit to make other people aware so they can make an informed decision. I’m shaking just writing this post right now thinking about what might become of me. I don’t really know who to turn to, or if anything can be done for me. I’m pretty scared.
 
Adapt -

First off, relax. There's no point in worrying about possible effects 20 years down the road - you might get hit by a bus tomorrow and then you won't have to worry about a damn thing. =D

Using mephedrone less than 20 times puts you squarely in the weekend warrior category, and there are people who have used literally 10 to 100 times what you have. We don't see a corresponding increase in these symptoms.

The major issue with mephedrone is the anxiety ridden days after that many do not relate directly to use. This causes a ridiculous amount of worry, and freakouts over small things. I have experienced the speech issues and memory problems - so I stopped using it forever. And the problems have gone away completely.

Exercise, eat well, get good sleep, and remember that it's pointless to wonder what coulda shoulda woulda been - and just live your life with lessons learned from now on.
 
What's with this "flephedrone is not like mephedrone"? These are the last methcathinone analogs I took. I don't care if there'll be some mephedrone isomer with again great effects "similar to cocaine and MDMA" (well, it's one or another... or what? I can say that none of people who stated mephedrone is similar to cocaine or MDMA ever took either). And by the way, I just can't believe this dosage you present. Your vendors (this isn't directed to anyone in particular but to all people who took/take 500mg-1000mg) make a damned idiots out of you. I remember taking it in a much lower dose and it was already dirty to me. I do have experiences with cocaine, methamphetamine, methcathinone (pure >99%, lab grade), or 4-methylaminorex (also lab grade). 500mg is a ridiculous dose as a starter for mephedrone. No wonder it happens to show its toxicity so fast in so many users. Anyway, I've never been addicted to aforementioned stimulants so I didn't develop tolerance.
 
Adapt -

First off, relax. There's no point in worrying about possible effects 20 years down the road - you might get hit by a bus tomorrow and then you won't have to worry about a damn thing. =D

Using mephedrone less than 20 times puts you squarely in the weekend warrior category, and there are people who have used literally 10 to 100 times what you have. We don't see a corresponding increase in these symptoms.

The major issue with mephedrone is the anxiety ridden days after that many do not relate directly to use. This causes a ridiculous amount of worry, and freakouts over small things. I have experienced the speech issues and memory problems - so I stopped using it forever. And the problems have gone away completely.

Exercise, eat well, get good sleep, and remember that it's pointless to wonder what coulda shoulda woulda been - and just live your life with lessons learned from now on.

Thanks mate, I spoke to a friend today, and he said a similar thing. To be fair, I live a very hectic lifestyle, and my sleep patterns leave a lot to be desired. I'm going to go to the docs anyway, and have myself checked out, but you know how it is when you're having a little panic. I'm a level headed person generally, but sometimes its just hard to keep these things down. I'm never going to touch the stuff again whatever happens! This amount of stress is not worth the fun! Either way, I'll keep posting back here after I go to the docs.
 
i have taken mephedrone ... and blow out of the shops i prefered blow and

me and my mates took it for 3 months till it was banned ....

we would stay up friday to sunday without sleep

and would take it once of twice durin the week also..

all i have gotton was

weight loss
hands would be cold when i was on it
spots on body

thats it never anything els really ....

i also found blow to be way harder on your body than mephredrone
 
I tried it one evening, and the physical effects were pronounced and of concern but i swear I could even *feel* my neurons sizzling......that was enough for me!


- I felt this! I felt like I was actually doing damage to my brain, and had to reign it in!

Maybe thats why my brain feels so screwed up 6 months later!
 
From a one time use?

I’d probably used it 10 - 15 times over about 14 months, haven’t done it for 6 months now, and won’t again.

Dose was about 3 caps (they are about 250mg a cap right?), maybe more on one or two occasions

Always done on one night, then nothing for a few weeks. No other drugs taken in the meantime.
 
That's 750mg-1g in a session, one session a month. Well that makes more sense to justify your feeling damaged
 
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