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Opioids I am going to be a guinea pig and attempt to reverse my opioid addiction.

lozgod

Bluelighter
Joined
Jan 29, 2010
Messages
715
I have a bunch of articles saved in my favorites, too many to quote right now but you can research it on your own. Check out Oxytrex, ultra low dose naltrexone, low dose naltrexone, and anything related as you research you should be lead down more paths.

Here it is summed up.

There is a lot of evidence on the net about using ultra low doses of naltrexone along side of narcotics to prevent tolerance and addiction. Also there are claims to reverse physical and mental addiction using the same. The dose is ridiculously low but seems to work. The dosage is 100,000th to 1,000,000th the dose of the DOC. Since I am deep in to my addiction I am going to use the 100,000th of a dose protocol.

In the Oxytrex study they created opioid Dependant rats, rats that used the 1,000,000th of a dosage NTXN that never showed signs of withdrawal at discontinuance, and then they took the Dependant rats and reversed their dependence using the 1,000,000th dosage IN ONE DAY. These rats only became Dependant in 5 days so I do not expect to be cured in one day. It may not work at all but it is worth a shot.

I plan on using oxycodone for 2 weeks using 100,000th of a naltrexone dosage alongside of my oxy usage. Then discontinue and see if the physical dependence is gone. Should it not be I will either continue the protocol or go through withdrawal for 3 days to clear my system out.

Second stage of the experiment is to use a low dose of naltrexone to jump start endorphins.

Studies show that 3mgs of naltrexone and 50mgs of naltrexone both cause and increase of 200-300% in endorphin production. In both the increase of endorphins lasts over 24 hours. In the 3mg dosage the naltrexone's blockade of opioid receptors lasts 4 hours vs. the blockade of 28 hours with the 50mg dosage.

This in theory should kill cravings due to the receptors being fed by the increased endorphin production and also normalize brain function.

I am a believer that us opiate addicts began using and continued using because, well in my experience opiates made me feel normal. I was confident, ambitious, positive, etc in the beginning before I paid the piper with an addiction.

I understand some people are going to believe this is not going to work. I understand, and I know people have discussed this numerous times but I haven't seen anyone from my search actually put the idea in practice other than trying to lower their tolerance. So I am asking for no negativity or rudeness if you do not mind. This may not work but it is an attempt to beat addiction and if it works it may help a lot of people.

So if you do have an opinion it isn't going to work and is a waste of time please be constructive about it if you do not mind.

Thanks. Waiting on the naltrexone. As soon as I receive it this thread will be a journal of my progress, success or failure.
 
No opinion about it, I am a man of science and interested in hearing your results. I myself am contemplating a little experiment in tolerance reversal as well, however via a completely different method.
 
No opinion about it, I am a man of science and interested in hearing your results. I myself am contemplating a little experiment in tolerance reversal as well, however via a completely different method.

Have a link to your method or care to share here?
 
I don't know enough about it yet to have an opinion. But you've got me interested so I'll search a bit. If you have some extra time, could you post a few links? Definitely interested in reading about the process and results of your experiment. Good luck.
 
Have a link to your method or care to share here?

Search google for trifluoperazine and opioids for info. Basically, in mice it was shown that a dose of trifluoperazine (stelazine) can reduce/remove opioid tolerance.

I've been trying to ask around BL for real world experiences, but nothing has come up so far. Trifluoperazine is a rare anti-psychotic these days due to it's side-effects.
 
I don't know enough about it yet to have an opinion. But you've got me interested so I'll search a bit. If you have some extra time, could you post a few links? Definitely interested in reading about the process and results of your experiment. Good luck.

http://www.annieappleseedproject.org/ullownaltopr.html

This link actually references a link here. http://www.drugs-forum.com/forum/showthread.php?t=56493

Cool diary http://web.archive.org/web/20040416055559/dilaudid.net/uldntx-trial.shtml

Interview with one of the pioneers of low dose not to be confused with ultra low dose. http://www.lowdosenaltrexone.org/gazorpa/interview.html

Info on Endorphin Deficiency Syndrome (which I believe is a common thread among opiate addicts) http://www.vicodinwithdrawal.org/alternative-medicine/endorphin-deficiency-syndrom-eds/

LDN for Suboxone PAWS Discussion http://www.drugs.com/forum/featured-drugs/low-dose-naltrexone-therepy-suboxone-paws-54369.html

I have several more but these are the most basic ones. The rest are a lot of science mumbo jumbo I barely understand but am educating myself on to eventually be fluent in them hopefully.
 
Search google for trifluoperazine and opioids for info. Basically, in mice it was shown that a dose of trifluoperazine (stelazine) can reduce/remove opioid tolerance.

I've been trying to ask around BL for real world experiences, but nothing has come up so far. Trifluoperazine is a rare anti-psychotic these days due to it's side-effects.

Checked it out. Safety/side effect profile looks viscous though. For one it lowers the seizure threshold which is also lowered by opiods. So you are dealing with a double edged sword. Tread carefully there. Are you going to keep a log somewhere?
 
^ I'm considering doing something like that... I need to find out where my tolerance is at right now though, been clean for two weeks.

Did you have a physical addiction before the two weeks and if so is it a real genuine clean or a "I'm taking suboxone" clean?
 
Real genuine clean, I'm in Australia and subs aren't that common around here, at least in my experience, also I've been in a psych ward recently and so family is keeping a watchful eye that is about to turn away...
 
Check out this tread over in AusDD.

Have a chat to the OP and see what the side effects are.

Not a good idea if you ask me, but I have never tried it.
 
Checked it out. Safety/side effect profile looks viscous though. For one it lowers the seizure threshold which is also lowered by opiods. So you are dealing with a double edged sword. Tread carefully there. Are you going to keep a log somewhere?

I was under the impression that acute opioid withdrawal, not opioids caused the lowering of the seizure threshold. Same with benzos, the seizure threshold is lowered by the withdrawal rather than the medication itself.

People who overdose on opioids don't have seizures, in fact it's quite the opposite.

http://en.wikipedia.org/wiki/Toxidromes#Opiate_toxidrome
 
While I have my doubts regarding if this will work, I commend your enthusiasm and willingness to give it a try.

Also, you may want to check out proglumide. There is a lot of research that proglumide it also a great tool in terms of fending off tolerance and dependence. good luck and keep us updated.

Oh and just 1 more thing to keep in mind. Unfortunately your "study" will not be able to account for the placebo effect. Because you will know what drugs you will be taking, it cannot be "double blind", and its possible that any effects you may experience might be due (at least to some degree) to placebo.-DG
 
^ You can't placebo physical dependence away, especially after weeks of use.

I've heard of this technique and wanted to do it ever since I read about it. I'll be very interested in hearing the results, opiates-tolerance-addiction= perfection I think.

I'd also be interested to hear about any side effects you experience. I might however recomend that you start lower on the naltrexone. If 1/1,000,000th of a dose works then there's not really any need to use more then that. Also be careful with the fact that your tolerance will go down if this works, in which case you might need to change the opiate dose.
 
^ You can't placebo physical dependence away, especially after weeks of use.

I've heard of this technique and wanted to do it ever since I read about it. I'll be very interested in hearing the results, opiates-tolerance-addiction= perfection I think.

I'd also be interested to hear about any side effects you experience. I might however recomend that you start lower on the naltrexone. If 1/1,000,000th of a dose works then there's not really any need to use more then that. Also be careful with the fact that your tolerance will go down if this works, in which case you might need to change the opiate dose.

Well I agree that placebo would not be able to completely rid one of dependence, remember that at best the OP may experience SOME decrease in withdrawal symptoms/dependence, and I think its completely possible that someone might believe they are feeling less withdrawal due to placebo alone.-DG
 
...This in theory should kill cravings due to the receptors being fed by the increased endorphin production and also normalize brain function...I understand some people are going to believe this is not going to work.

So naive. You should spend what energy and drive you have in seeking real help. The problem is that you continue to believe that you can get by in life by medicating yourself; the same thinking that got you into this deep mess in the first place. You deserve real help. Please reconsider. Do not extend your suffering needlessly.
 
Does anyone read the post or just say revia implants suck when they see naltrexone???

Check out this tread over in AusDD.

Have a chat to the OP and see what the side effects are.

Not a good idea if you ask me, but I have never tried it.

I appreciate the input but posts like this are aggravating. There is a day and night difference between what I am doing and what that thread is about. I AM NOT GETTING AN IMPLANT NOR AM I TAKING A FULL DOSE. I AM TAKING AN ULTRA LOW DOSE PROTOCOL (less than micro grams) FOLLOWED BY A LOW DOSE PROTOCOL OF 3MGs.

PLEASE READ MY ENTIRE DESCRIPTION OR DO NOT BOTHER POSTING PLEASE!! :X :X :X :X :X :X :X
 
Well I agree that placebo would not be able to completely rid one of dependence, remember that at best the OP may experience SOME decrease in withdrawal symptoms/dependence, and I think its completely possible that someone might believe they are feeling less withdrawal due to placebo alone.-DG

In regards to this discussion of placebo and WD, I certainly believe it is possible to think yourself into a worse WD and I know several other BL'ers (at least when I used to post here) who agree with that sentiment.
 
So naive. You should spend what energy and drive you have in seeking real help. The problem is that you continue to believe that you can get by in life by medicating yourself; the same thinking that got you into this deep mess in the first place. You deserve real help. Please reconsider. Do not extend your suffering needlessly.

Spent 9 months in jail, followed by 6 months of treatment, that resulted in 2 years clean on the streets, did up to step 8 in Narcotics Anonymous, had a a sponsor, home group, spoke at conventions but was never truly happy, diagnosed depressed, given SSRIs, nothing ever made me happy. I believe myself and many other opiate addicts have endorphin issues. Scientific studies show early childhood stress during emotional development may cause endorphin issues as adults and lead to opiate abuse. Low dose naltrexone is a tool to fix this problem.

I understand your stance and I AND MANY MANY MANY medical professionals believe this is real help. Problem is I can not find a doctor locally that is familiar with LDN and its benefits but google and YouTube it.

Because of the scientific literature and studies behind this I believe it will work. Not because of an educated guess but because of real world usage.

If it doesn't work I promise you I will seek help. I just believe the way opiate addiction is handled now is like trying to navigate Chicago with a map of Detroit. SSRI's, methadone, that ultra poisonous bupe, gratitude lists, prayer and meditation, etc. does not correct endorphin issues which most opiate abusers have that create the cravings and feeling of normalcy that only opiates can bring. Now a drug that gets you no higher than asprin is being proven to help people. Just because I can not find a doctor to prescribe it doesn't mean I will not give it a shot.
 
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Scientific studies show early childhood stress during emotional development may cause endorphin issues as adults and lead to opiate abuse. Low dose naltrexone is a tool to fix this problem.

Interesting, I will have to investigate that further...
 
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