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Opioids I am going to be a guinea pig and attempt to reverse my opioid addiction.

lozgod said:
I really respect someone that says what you just said. Instead of saying it won't work and there is only one way you instead say you will research it and come to your own conclusions. Refreshing.
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My parents put me on Anti-Depressants starting when I was 10 in 4th grade because according to them I was "obsessed with death and unhappy." Since then I've been on Prozac, Zoloft, Wellbutrin, Effexor XR, Abilify, Remeron, Cymbalta, and a few others all before the age of 18. I was also on Ritalin, Focalin, Straterra, Adderall, and Adderall XR for ADD. All the antidepressents did was make me gain weight and feel even worse about myself, and all the ADD meds ever did (until I was a Junior in high school when they started to work for studying and tests) was make me lose weight which made me happier and more confident. Eventually I discovered vicodin, percocet, and ultimately began snorting OxyContin daily which were the only prescription drugs that ever made me happy. In my opinion I was bred by my parents and psychiatrists as an adolescent to think that drugs were the solution to my problems, which I still believe today. I ended up in rehab and fought relentlessly with the AA bookthumpers when they told me my depression was a side-effect of my addiction, when my addiction started over a decade after my depression. Since then I was diagnosed with Opioid Responsive Depression, which explains why none of the anti-depressants ever worked and opiates totally did. I've been on suboxone for nearly two years as an antidepressant and its the only thing that's worked besides OC. I've been interested in naltrexone ever since my psychiatrist told me about it, although I've heard it can be dangerous and 1/100 people will die during the procedure due to inexperienced anesthesiologists as very few high-end clinics will perform the procedure.

I commend you for trying this out and hope that it works...be sure to let me know as I may be interested in trying this out myself one day. Good luck! I'm not religious but I'll pray for the best and hope for it to work out for you. =D

I've always believed that straight up opiate addicts are a lot different from alcoholics and other drug addicts and there's a lot more treatment options available to us. Maybe Naltrexone will one day prove that. :\
 
I've been interested in naltrexone ever since my psychiatrist told me about it, although I've heard it can be dangerous and 1/100 people will die during the procedure due to inexperienced anesthesiologists as very few high-end clinics will perform the procedure.
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During what procedure... are you talking about when they put you in a coma for WD?
 
Thizzcobar said:
My parents put me on Anti-Depressants starting when I was 10 in 4th grade because according to them I was "obsessed with death and unhappy." Since then I've been on Prozac, Zoloft, Wellbutrin, Effexor XR, Abilify, Remeron, Cymbalta, and a few others all before the age of 18. I was also on Ritalin, Focalin, Straterra, Adderall, and Adderall XR for ADD. All the antidepressants did was make me gain weight and feel even worse about myself, and all the ADD meds ever did (until I was a Junior in high school when they started to work for studying and tests) was make me lose weight which made me happier and more confident. Eventually I discovered vicodin, percocet, and ultimately began snorting OxyContin daily which were the only prescription drugs that ever made me happy. In my opinion I was bred by my parents and psychiatrists as an adolescent to think that drugs were the solution to my problems, which I still believe today. I ended up in rehab and fought relentlessly with the AA bookthumpers when they told me my depression was a side-effect of my addiction, when my addiction started over a decade after my depression. Since then I was diagnosed with Opioid Responsive Depression, which explains why none of the anti-depressants ever worked and opiates totally did. I've been on suboxone for nearly two years as an antidepressant and its the only thing that's worked besides OC. I've been interested in naltrexone ever since my psychiatrist told me about it, although I've heard it can be dangerous and 1/100 people will die during the procedure due to inexperienced anesthesiologists as very few high-end clinics will perform the procedure.

I commend you for trying this out and hope that it works...be sure to let me know as I may be interested in trying this out myself one day. Good luck! I'm not religious but I'll pray for the best and hope for it to work out for you. =D

I've always believed that straight up opiate addicts are a lot different from alcoholics and other drug addicts and there's a lot more treatment options available to us. Maybe Naltrexone will one day prove that. :\
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I am no psychologist but sounds to me that your addiction was the result of your depression not the other way around.

Please do not try the at home rapid detox. Doesn't sound like you are but threw that out just in case.

Good to hear the suboxone is working, sounds like you have an endorphin issue then. My problem with long term suboxone is that it is a partial agonist. The reason I have a problem with that is we have those receptors for a reason. They are designed for full agonists so dealing with a partial agonist is not a normal state for the brain so long term who knows the consequences. May be nothing of course but that scares me personally.

Full dose naltrexone would probably make your depression worse but I encourage you to research "low dose naltrexone" for depression. Seems to work wonders in those that SSRI's didn't work for. A 25-50mg dose WILL increase your endorphin production for up to 24 hours but will also block the receptors they need for to reach for 28+ hours to improve your depression.

A 1.5-4.5mg dosage will create the same increase of endorphins for the same duration but only block the endorphins for 4 hours and ideally you take it a few hours before bed so those 4 hours are during sleep. You wake up and for 24 hours your brain is functioning optimally endorphin wise alleviating any endorphin related conditions (AIDS, certain cancers, MS, depression, Chrohn's disease, chronic fatigue, the list goes on). That is the theory and in practice the success rate is extraordinarily high.

So why isn't this being studied more intensely? This seems like a miracle drug. Well it may in fact be but the patent expired many years ago. No one can claim the miracle drug and make a profit on it so it doesn't make sense financially to invest the millions of dollars it takes to research it. Medicine and health care is a business. It is not based on what is best for people unless those people are on the board of directors of a pharmaceutical company.
 
Mr Blonde said:
^ Endorphins can alleviate AIDS?
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Endorphins have a big time effect on the immune system and some of it is cell specific to AIDS.


http://www.lowdosenaltrexone.org/ldn_and_hiv.htm
Dr. Bihari reports that, as of November 2001, a group of 18 such patients had an average of 9.5 years of known HIV-positive status. They had been taking LDN continuously for an average of almost 7 years, and none had participated in regular maintenance therapy with HAART. Had these patients been untreated, their CD4 counts by now should have been at quite low levels and their clinical status should have been perilous.

Instead, the most recent laboratory data for these patients shows that the vital indicators of immune status have, on average, declined only minimally during the many years. The average CD4 count within the group is 445 cells (normal = 550-1500) and the average CD4% is 28.6% (normal = 27%-53%). And, indeed, they all remain free of opportunistic infections and other indicators of AIDS.

All of these patients started with CD4 counts of greater than 300. Dr. Bihari indicates that most patients with lower CD4 counts showed a decline in CD4 number and percentage over time, though much more slowly than untreated patients used to.
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Checked order status. ETA is between 4/24-4/26 which is perfect timing because I go to my pain management doctor on the 23rd. So I will have all the naltrexone and oxycodone I need. So about a week or so and it will begin.

Really appreciate the interest and support I am getting as well. This will give me more 'stick-to-it-ness' when I want to give up or cheat the process. Going to be 100% honest in the log so no worries there. My worry is the addict in me taking too high of doses to get hi and ruining the experiment by running out of oxy.

Hopefully it will work for me as it did those in the trials. Right now I am in the 300+mg range to get off a little, 600+mg to get shit faced and nodding and about 120-150mg to get un-ill completely, 60-90 I will feel better but not quite good to go uet. Probably a couple grams to OD. While running the naltrexone I will not do more than 30mg increments for safety's sake.
 
Friend sorta tried what you are thinking. He has been in the game 30 years.
He questions your ability to measure out the micro doses.
As you know not only that has to be perfect but also keeping opiates in check.
Probably a better chance if you had someone not in the game.. to enforce

By the end of the month he had totally lost track.
He started totally clean..got scripted 240/30mg oxy and 180 8mg dilly
It aint easy.
Looking for that free lunch
He PW at the end and can only describe it as how others describe ibogaine.
Good vs evil
Thought he could fly if he wanted to
One with the universe.

At the end he went straight to 3mg nalt.nightly and says fuck opiates.
This was a year ago.
No craving
LIFE IS GOOD

g/l
 
youto said:
Friend sorta tried what you are thinking. He has been in the game 30 years.
He questions your ability to measure out the micro doses.
As you know not only that has to be perfect but also keeping opiates in check.
Probably a better chance if you had someone not in the game.. to enforce

By the end of the month he had totally lost track.
He started totally clean..got scripted 240/30mg oxy and 180 8mg dilly
It aint easy.
Looking for that free lunch
He PW at the end and can only describe it as how others describe ibogaine.
Good vs evil
Thought he could fly if he wanted to
One with the universe.

At the end he went straight to 3mg nalt.nightly and says fuck opiates.
This was a year ago.
No craving
LIFE IS GOOD

g/l
Click to expand...

Guess the ends justified the means. Thanks for the post. Gave me some hope in what I am doing. I am pretty confident it will work, not because I am a genius but because science backs it up.
 
This experiment should start Monday. After much research I have decided on my first dosage to be 3mcgs and 30mgs of oxycodone to mimic the oxytrex dosage which is 10mg/1mcg.

Now assuming I have to up the oxycodone to have an effect I am leaning against upping the naltrexone dosage. I am somewhat scientifically inclined but this is new ground for me. I believe part of the effect is from naltrexone having a tendency to attach to delta receptors first. This somehow reverses/slows/stops tolerance if I interpreting this correctly. Also I am hypothesizing that this lessens allows for more oxycodone to attach to the mu receptors increasing its effect.

Anyone with more knowledge PLEASE chime in here.
 
To the skeptics... Scientists have very recently discovered that Vitamin D, injected into the right place in the body, can actually reverse/stop the growth of skin cancer. Human trials have been supposedly showing positive results with this treatment and a new vitamin D medication is being looked at for release in about five years.

So much money has been spent on cancer research, yet it has taken many years to reach the point where Vitamin D was looked at as a potential treatment... Medicine is mostly still a very crude science, filled with lucky guesses, and many hit and misses.

We are far from knowing everything so I am completely convinced we will one day be able to use opiates without addiction and tolerance.

But...

How many scientists do you think are currently working on a way to keep junkies higher, for longer?

How many pharmaceutical companies want to create a product that will decimate their yearly earnings?

To create an opiate combination that reduces tolerance would mean people would buy less drugs, and pain patients would only really need morpine, or codeine even - drugs that are not under patents.

I wanna add something positive to the 'hunt' so i am really thinking this experiment is a step in the right direction and i wanna support OP.

Thanks for the info on naltrexone availability. I will try to hunt some down and see what can be done for my little mischievous monkey... :)
 
To the OP,
How are you going to weigh out and dose in the microgram range? (Sorry if you answered this earlier)
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How many scientists do you think are currently working on a way to keep junkies higher, for longer?
Click to expand...
They're not looking at it from a recreational use stand point. They're interested in lowering tolerance and therefore dependency.

How many pharmaceutical companies want to create a product that will decimate their yearly earnings?
Click to expand...
I don't see how it will do that. Not only will they try to sell it as a harder to abuse pill, but they'll also tout its efficiency. Plus it'll be on patent for a bit of time...
They're only concerned with volume while it's under patent, and there's no reason to believe that a drug like this won't deliver. Notice how "new and improved" versions only come out after the patent is about to expire?

If you're interested in that stuff, look into Pain Therapeutics, the company developing and testing oxytrex. They have several abuse resistant opiates in the pipeline, which aren't even going to be marketed and sold by them.
 
I am having conflicting ideas on how to do this. I have found abstracts with various doses from 2mcgs to 125mcgs. Going to start low and up dosages and note effects. Guess I can not go wrong that way.

I will have all the naltrexone I need. Problem is I will only have 50 30mg oxycodones. I use about 8-10 a day so I need the experiment to take off quickly and according to the research I find it does.
 
phrozen said:
To the OP,
How are you going to weigh out and dose in the microgram range? (Sorry if you answered this earlier)
Click to expand...

Actually do to its water solubility it will be easy to make an ultra low dose solution. 1 50mg pill mixed with 50ml of water makes a 1mg/1ml dose. Add 1ml to 49mls and you now have 20mcgs/ml. Then ad 1ml to 9mls and you have 2mcgs/ml.
 
My Naltrexone has been sitting in US Customs for 28 hours now. Starting to worry I won't be able to do this. Might just end up paying $90 for a seizure letter.
 
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